Article
Psychiatry
Joanna M. Fiszdon, Jimmy Choi, Kaicheng Wang, Lori T. Parente, Sean Hallinan, Emma Burton, Morris D. Bell, Steve Martino
Summary: Motivational interviewing (MI) shows promise in improving attendance in cognitive training, and may be a valuable addition to efforts to promote initial treatment engagement and adherence.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychiatry
Julia M. Lappin, Kimberley Davies, Maryanne O'Donnell, Ishan C. Walpola
Summary: This study aimed to understand the use of clozapine and electroconvulsive therapy (ECT) in individuals with treatment-resistant psychosis. The study found that the utilization of these treatments was low and clozapine trials were often terminated prematurely without adequate testing. The study suggests strategies should be implemented to optimize the use of clozapine therapy and ECT in clinical settings to improve the therapeutic effectiveness for treatment-resistant psychosis.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Health Care Sciences & Services
Gul Dikec, Ellie Brown, Daniel Bressington, Andrew Thompson, Richard Gray
Summary: The role of antipsychotic medication in supporting young people in their recovery from early psychosis is complex and controversial. There is a paucity of high-quality evidence on the safety and effectiveness of psychosocial interventions to enhance medication adherence in young people with early psychosis.
Article
Psychology, Clinical
Martin Lepage, Christopher R. Bowie, Tina Montreuil, Larry Baer, Olivier Percie du Sert, Tania Lecomte, Ridha Joober, Amal Abdel-Baki, G. Eric Jarvis, Howard C. Margolese, Luigi De Benedictis, Norbert Schmitz, Ashok K. Malla
Summary: A randomized controlled trial tested the efficacy of a group cognitive-behavioral therapy intervention for social anxiety in youth who experienced the first episode of psychosis. The results showed that both interventions led to a reduction in social anxiety, but the CBT-SA intervention had a positive effect on negative symptoms, functioning, and recovery.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Nursing
Matilda Ryan, Dina Sattenspiel, Alexander Chianese, Helen Rice
Summary: Treatment-resistant schizophrenia (TRS) often coexists with other medical conditions, and patients may not respond well to second-generation antipsychotic medications. While clozapine is the primary pharmacological treatment, it may not provide complete symptom relief. Cognitive behavioral therapy (CBT) as an adjunctive treatment can significantly reduce positive symptoms in patients with TRS.
AMERICAN JOURNAL OF NURSING
(2022)
Article
Psychiatry
Jessie Mbwambo, Sylvia Kaaya, Isaac Lema, Christopher J. Burant, Catherine Magwiza, Kim Madundo, Godwin Njiro, Carol E. Blixen, Kristin A. Cassidy, Jennifer B. Levin, Martha Sajatovic
Summary: The study suggests that combining long-acting antipsychotic medication with a customized adherence enhancement intervention is feasible and acceptable in Tanzanians with chronic psychotic disorders.
Review
Psychiatry
Ahmad Mayeli, Kevin J. Clancy, Susan Sonnenschein, Deepak K. Sarpal, Fabio Ferrarelli
Summary: Cognitive dysfunction is a key characteristic of schizophrenia, which has negative effects on patients' daily functioning and overall clinical outcomes. However, research has shown that cognitive deficits can be present several years before the onset of psychosis. Most treatment interventions for cognitive dysfunction in schizophrenia have focused on chronic patients, neglecting those at high risk or in the early stages of the disease. This article provides a review of cognitive interventions in schizophrenia patients, with a specific focus on preemptive interventions for at-risk/early course individuals, and discusses current challenges and suggestions for future improvements.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
Lindsay A. Bornheimer, Juliann Li Verdugo, Joshua Holzworth, Vitalis Im, Fonda N. Smith, Hannah Sliwa, Stephan F. Taylor, Cheryl A. King, Timothy Florence, Nicholas Tarrier, Joseph A. Himle
Summary: Suicide is a major cause of death among adults with schizophrenia spectrum disorders. This article presents the modification methodology of a cognitive-behavioral suicide prevention treatment for psychosis in US community mental health settings, and highlights the importance of collaboration among stakeholders, researchers, and scholarly experts in improving access and quality of this treatment.
PSYCHIATRY RESEARCH
(2022)
Article
Psychology, Clinical
Emily Eisner, Natalie Berry, Rohan Morris, Richard Emsley, Gillian Haddock, Matthew Machin, Lamiece Hassan, Sandra Bucci
Summary: Psychosis patients have positive attitudes towards psychological interventions delivered via smartphone apps. This study found that individuals with psychosis engaged well with the Actissist app, particularly in the domains of voice-hearing and paranoia. Reminders generated by the app successfully increased app engagement. Future studies should explore non-incentivized engagement in larger samples.
JOURNAL OF MENTAL HEALTH
(2023)
Review
Medicine, General & Internal
Mitchell D. Arnovitz, Andrew J. Spitzberg, Ashkhan J. Davani, Nehal P. Vadhan, Julie Holland, John M. Kane, Timothy Michaels
Summary: The negative symptoms of schizophrenia severely limit daily functioning, and there are currently no FDA-approved treatments for them. 3,4-Methylenedioxy methamphetamine (MDMA) has potential as a novel therapeutic due to its ability to enhance social interactions, generate empathy, and induce a state of metaplasticity in the brain. This review provides a rationale for the use of MDMA in the treatment of negative symptoms by reviewing the literature on negative symptoms, their treatment, MDMA, and MDMA-assisted therapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Psychiatry
Huajie Jin, Paul Tappenden, James H. MacCabe, Stewart Robinson, Paul McCrone, Sarah Byford
Summary: The study aimed to assess the cost-effectiveness of improving adherence to NICE schizophrenia guideline recommendations. Results showed that full adherence to the guidelines would decrease costs and improve quality-adjusted life-years, with prompt provision of clozapine for treatment-resistant schizophrenia patients having the greatest net monetary benefit.
BRITISH JOURNAL OF PSYCHIATRY
(2021)
Article
Psychology, Clinical
Victor J. Pokorny, Timothy J. Lano, Michael-Paul Schallmo, Cheryl A. Olman, Scott R. Sponheim
Summary: The accurate perception of visual contours is essential for seeing and differentiating objects in the environment, but individuals with schizophrenia may have diminished ability in detecting visual contours and processing perceptual contexts created by surrounding stimuli. The study aimed to understand the biological basis of these impairments and found that schizophrenia patients exhibited weakened suppression by the perceptual context. Neural responses in later stages of processing showed group differences and flanker orientation effects, indicating abnormalities in higher-order sensory and cognitive processes.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Kara Dempster, Annie Li, Priyadharshini Sabesan, Ross Norman, Lena Palaniyappan
Summary: The study examined how using a <50% improvement threshold for total symptoms in first episode schizophrenia patients could best predict global functioning over a period of 5 years.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Psychiatry
Amy Hardy, Sophie Good, Jayde Dix, Eleanor Longden
Summary: This study conducted an audit of a post-traumatic stress in psychosis clinic to evaluate the implementation of trauma-focused cognitive-behavior therapy for people with post-traumatic stress and psychosis. The results showed that this therapy can be safe and effective in routine care, with significant improvements in post-traumatic stress symptoms. The experiences of service users highlighted the importance of sufficient support and continuity of care during and after therapy.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Neurosciences
Qiongqiong Wu, Xiaoyi Wang, Ying Wang, Yu-Jun Long, Jing-Ping Zhao, Ren-Rong Wu
Summary: This review focuses on the causal mechanisms and treatment options for the negative symptoms and cognitive dysfunction in schizophrenia, providing insights into potential therapeutic strategies for the future.
NEUROSCIENCE BULLETIN
(2021)
Article
Neurosciences
Katrina Aberizk, Meghan A. Collins, Jean Addington, Carrie E. Bearden, Kristin S. Cadenhead, Barbara A. Cornblatt, Daniel H. Mathalon, Thomas H. McGlashan, Diana O. Perkins, Ming T. Tsuang, Scott W. Woods, Tyrone D. Cannon, Elaine F. Walker
Summary: This study investigates the relationship between life event stress (LES) and cortical thickness in individuals at clinical high risk for psychosis (CHR-P). The findings suggest that LES is associated with reduced baseline cortical thickness in both CHR-P and healthy individuals. It is also found that CHR-P status is linked with thinner cortex in select regions even after controlling for LES.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Article
Psychiatry
Nina Zaks, Tjasa Velikonja, Muhammad A. Parvaz, Jamie Zinberg, Monica Done, Daniel H. Mathalon, Jean Addington, Kristin Cadenhead, Tyrone Cannon, Barbara Cornblatt, Thomas McGlashan, Diana Perkins, William S. Stone, Ming Tsuang, Elaine Walker, Scott W. Woods, Matcheri S. Keshavan, Daniel J. Buysse, Eva Velthorst, Carrie E. Bearden
Summary: The study found a strong correlation between disturbed sleep and CHR symptoms, with depression playing a significant role in this association. Importantly, sleep was identified as a significant predictor of CHR symptoms, but not vice versa.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Psychology, Clinical
Wisteria Deng, Jean Addington, Carrie E. Bearden, Kristin S. Cadenhead, Barbara A. Cornblatt, Daniel H. Mathalon, Diana O. Perkins, Larry J. Seidman, Ming T. Tsuang, Scott W. Woods, Elaine F. Walker, Tyrone D. Cannon
Summary: This study found that there are different covariant trajectories of social anxiety and positive symptoms over time in individuals at clinical high-risk for psychosis. One subgroup showed sustained social anxiety despite moderate recovery in positive symptoms, while the other two subgroups showed recovery in both social anxiety and positive symptoms. The subgroup with sustained social anxiety had poorer long-term functional outcomes and higher levels of genetic and environmental risk factors for psychosis.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Kelsey A. Ludwig, Benjamin Brandrett, Michelle H. Lim, Paul Mihas, David L. Penn
Summary: The study used qualitative interviews to explore loneliness among individuals diagnosed with schizophrenia spectrum disorders. The results highlighted significant feelings of loneliness among this population, with key themes including aspects of the physical environment, social context, and psychological functioning that impact these feelings.
JOURNAL OF MENTAL HEALTH
(2022)
Article
Psychiatry
Olga Santesteban-Echarri, Lu Liu, Madeline Miller, Carrie E. Bearden, Kristin S. Cadenhead, Tyrone D. Cannon, Barbara A. Cornblatt, Matcheri Keshavan, Daniel H. Mathalon, Thomas H. McGlashan, Diana O. Perkins, Larry J. Seidman, William S. Stone, Ming T. Tsuang, Elaine F. Walker, Scott W. Woods, Jean Addington
Summary: Cannabis use is more prevalent among youth at clinical high-risk for psychosis. Cannabis use is associated with increased frequency and severity, as well as the presence of cannabis use disorder. However, cannabis use does not appear to impact clinical status or the transition to psychosis.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychiatry
Lauren N. N. Tronick, Heline Mirzakhanian, Jean Addington, Carrie E. E. Bearden, Tyrone D. D. Cannon, Barbara A. A. Cornblatt, Matcheri Keshavan, Daniel H. H. Mathalon, Thomas H. H. McGlashan, Diana O. O. Perkins, William Stone, Ming T. T. Tsuang, Elaine F. F. Walker, Scott W. W. Woods, Kristin S. S. Cadenhead
Summary: This study aims to explore the risk of violence in individuals at clinical high risk for psychosis (CHR) and its relationship with psychosis risk symptoms and global functioning. It shows that CHR individuals are at higher risk of violence compared to healthy individuals and that this risk is associated with greater severity of symptoms, poor functioning, and risk for conversion to psychosis.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Meghan A. Collins, Jie Lisa Ji, Yoonho Chung, Cole A. Lympus, Yvette Afriyie-Agyemang, Jean M. Addington, Bradley G. Goodyear, Carrie E. Bearden, Kristin S. Cadenhead, Heline Mirzakhanian, Ming T. Tsuang, Barbara A. Cornblatt, Ricardo E. Carrion, Matcheri Keshavan, Wiliam S. Stone, Daniel H. Mathalon, Diana O. Perkins, Elaine F. Walker, Scott W. Woods, Albert R. Powers, Alan Anticevic, Tyrone D. Cannon
Summary: Progressive grey matter loss has been observed among individuals who convert to psychosis, and this study found that accelerated cortical thinning precedes psychosis onset and can differentiate converters from non-converters. These findings highlight the importance of identifying neurobiological mechanisms prior to conversion for early intervention.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychiatry
Esra Sefik, Michelle Boamah, Jean Addington, Carrie E. Bearden, Kristin S. Cadenhead, Barbara A. Cornblatt, Matcheri S. Keshavan, Daniel H. Mathalon, Diana O. Perkins, William S. Stone, Ming T. Tsuang, Scott W. Woods, Tyrone D. Cannon, Elaine F. Walker
Summary: This study found clinically relevant deviations in cerebellar cortex and white matter structures among CHR individuals, highlighting the importance of considering the complex interplay between sex and age when studying the neuromaturational substrates of psychosis risk.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychiatry
Mariapaola Barbato, Lu Liu, Carrie E. Bearden, Kristin S. Cadenhead, Barbara A. Cornblatt, Matcheri Keshavan, Daniel H. Mathalon, Thomas H. McGlashan, Diana O. Perkins, Larry J. Seidman, William Stone, Ming T. Tsuang, Elaine F. Walker, Scott W. Woods, Tyrone D. Cannon, Jean Addington
Summary: This study aimed to assess the impact of migrant status on clinical symptoms and functional outcome in individuals at clinical high risk (CHR) for psychosis. The results showed no significant differences in symptoms or functioning between different groups at any time point. However, significant improvements in symptoms and functioning were observed within each group over time. Transition rates did not differ across groups.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Psychology, Clinical
Katrina Aberizk, Esra Sefik, Jean Addington, Alan Anticevic, Carrie E. E. Bearden, Kristin S. S. Cadenhead, Tyrone D. D. Cannon, Barbara A. A. Cornblatt, Matcheri Keshavan, Daniel H. H. Mathalon, Diana O. O. Perkins, William S. S. Stone, Ming T. T. Tsuang, Scott W. W. Woods, Elaine F. F. Walker
Summary: This study found that reduced hippocampal volume is a brain morphological feature of psychiatric conditions. It also observed associations between hippocampal volume and hippocampal functional connectivity with the inferior parietal lobe and thalamus. The results suggest that the functional connectivity of the hippocampus with the temporoparietal junction within the default mode network is sensitive to hippocampal volume.
CLINICAL PSYCHOLOGICAL SCIENCE
(2023)
Review
Psychology, Clinical
Benjamin Buck, Julia Browne, Emily C. Gagen, David L. Penn
Summary: This paper provides a descriptive and critical review of the literature on hostile attribution bias in psychotic disorders. The findings suggest that hostile attribution bias is elevated in schizophrenia and is related to anxiety, depression, and interpersonal conflict outcomes. However, there are still persistent questions in this research area, such as identifying the most effective measures and understanding how it presents.
JOURNAL OF MENTAL HEALTH
(2023)
Meeting Abstract
Neurosciences
Benson Ku, Katrina Aberizk, Jean Addington, Carrie Bearden, Kristin Cadenhead, Tyrone Cannon, Ricardo Carrion, Michael Compton, Barbara Cornblatt, Benjamin Druss, Daniel Mathalon, Diana Perkins, Ming Tsuang, Scott Woods, Elaine Walker
BIOLOGICAL PSYCHIATRY
(2022)
Article
Psychiatry
Michael S. Kraus, Trina M. Walker, Diana Perkins, Richard S. E. Keefe
SCHIZOPHRENIA RESEARCH-COGNITION
(2022)
Article
Psychology, Clinical
Maku Orleans-Pobee, Julia Browne, Kelsey Ludwig, Carrington Merritt, Claudio L. Battaglini, L. Fredrik Jarskog, Paschal Sheeran, David L. Penn
Summary: The study shows that the Physical Activity Can Enhance Life (PACE-Life) walking intervention has some impact on the health of individuals with SSDs, increasing participants' self-reported weekly walking time, reducing daily sitting time, and improving autonomous motivation and hip circumference. However, changes in Fitbit-recorded exercise behavior were minimal.
JOURNAL OF MENTAL HEALTH
(2022)
Article
Psychology, Clinical
Arundati Nagendra, Maku Orleans-Pobee, Rachel Spahnn, Mahogany Monette, Effua E. Sosoo, Amy E. Pinkham, David L. Penn
Summary: This study aimed to understand the level of attention given to racial and ethnic disparities in schizophrenia research published in high-impact US journals. The study found that 62% of the 474 US-based studies reported analyses by race or ethnicity, which is a significant increase compared to previous studies. However, there is still a need for more systematic and nuanced research on this topic.
JOURNAL OF MENTAL HEALTH
(2022)
