Review
Medicine, Research & Experimental
Min Lu, Meng Jia, Qun Wang, Yurong Guo, Chunlin Li, Boxu Ren, Feng Qian, Jianping Wu
Summary: Cardiac tissue ischemia/hypoxia increases glycolysis and lactic acid accumulation in cardiomyocytes, leading to intracellular metabolic acidosis. Sodium bicarbonate cotransporters (NBCs) play a vital role in modulating intracellular pH and maintaining sodium ion concentrations in cardiomyocytes, with NBCe1 being actively involved in myocardial ischemia/reperfusion (I/R) injury. Further studies on NBCe1 activity regulation mechanisms could offer novel therapeutic targets for preventing I/R-induced cardiac diseases.
Article
Multidisciplinary Sciences
Lisa Z. Fang, Victoria Linehan, Maria Licursi, Christian O. Alberto, Jacob L. Power, Matthew P. Parsons, Michiru Hirasawa
Summary: Hypothalamic inflammation can exacerbate obesity and fatty liver by stimulating appetite-promoting neurons.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Physiology
A. G. Dimitrov
Summary: This study introduces a new idea that electrogenic transporters determine cell resting state, challenging the previous assumption that pumps, especially the sodium one, determine it. By transferring control to electrogenic transporters, pumps can transfer energy to ionic gradients without losses, while the cell surface membrane potential is associated with the reversal potential of these transporters.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Hydrogen sulfide (H2S), previously recognized as a toxic gas, has now been acknowledged as an endogenously produced gaseous signaling molecule with diverse physiological and pathological functions at low concentrations. This review focuses on the renal production and functions of H2S, as well as its potential as a targeted therapeutic agent for renal pathologies such as hypertensive nephropathy, diabetic kidney disease, and water balance disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
S. E. Faraj, W. M. Valsecchi, N. T. Cerf, N. U. Fedosova, R. C. Rossi, M. R. Montes
Summary: The study found that although Na+ competes with H+ in ATPase activity, it was not possible to isolate a Na+-occluded state nor reveal any Na+ influx related to H,K-ATPase activity. The high rate of the E2K -> E1 transition in H,K-ATPase, not compatible with the presence of a K+-occluded form, agrees with the negligible level of occluded Rb+ found in the absence of added ligands.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2021)
Article
Biochemistry & Molecular Biology
Ryuta Kanai, Flemming Cornelius, Bente Vilsen, Chikashi Toyoshima
Summary: In this study, the 3.3 angstrom resolution structure of Na+,K+-ATPase (NKA) in the E2·2K(+) state was resolved using cryo-electron microscopy. The transition from the E2P state to the E2·2K(+) state involves the closure and locking of the extracellular ion pathway, as well as events at the phosphorylation site over 50 angstrom away. Furthermore, the binding of ATP to NKA in the E2·2K(+) state was found to relax the gating machinery and greatly accelerate the release of K+ into the cytoplasm.
Article
Multidisciplinary Sciences
Hongmei Yin, Yadong Zhong, Hui Wang, Jielun Hu, Shengkun Xia, Yuandong Xiao, Shaoping Nie, Mingyong Xie
Summary: The study found that exposure to high humidity environment can affect colonic urea-nitrogen metabolism by increasing the influx of colonic urea and altering gut microbiota composition, which may further impact host health outcomes.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Neurosciences
Annette Buur Steffensen, Beatriche Louise Edelbo, Dagne Barbuskaite, Soren Norge Andreassen, Markus Harboe Olsen, Kirsten Moller, Nanna MacAulay
Summary: Maintaining intracranial pressure (ICP) within the physiological range is crucial for proper brain function. Fluctuations in ICP during the light-dark phase cycle may complicate diagnosis and treatment choice for patients with pressure-related disorders. These fluctuations are likely caused by circadian or sleep-wake cycle-mediated modulation of cerebrospinal fluid (CSF) flow dynamics, which may also play a role in diurnal regulation of brain waste clearance.
FLUIDS AND BARRIERS OF THE CNS
(2023)
Article
Anatomy & Morphology
Victor Okoliko Ukwenya, Adelakun Sunday Aderemi, Olutayo Margaret Alese, Olabiyi Ayodeji Augustine
Summary: This study investigated the role of caffeic acid in FRU-STZ diabetic rats and found that it was able to restore reproductive function and reduce tissue damage in these rats.
Article
Toxicology
Reem Rida, Rawad Hodeify, Sawsan Kreydiyyeh
Summary: FTY720P, a potential causative agent of inflammatory bowel disease, reduces the activity and membrane abundance of Na+/K+ ATPase through the activation of S1PR2, inhibition of ERK, activation of p38 MAPK, PKC, and PI3K, and release of PGE2.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Cell Biology
V. S. Sokolov
Summary: The results of investigating the electrogenic transport of the Na,K-ATPase, an enzyme that actively transports Na and K ions through the cell membrane, are reviewed in this article. The movement of ions in access channels, which are channel-like structures connecting the ion binding centers with the solutions, is identified as the main contributor to the electric current generated by the Na,K-ATPase. The study used a model system consisting of a bilayer lipid membrane with adsorbed membrane fragments containing the Na,K-ATPase, and the impedance method was applied to investigate the access channels in the Na,K-ATPase. The review highlights the significant contribution of Yu.A. Chizmadzhev to the development of the theoretical model of transport processes in the Na,K-ATPase.
BIOLOGICHESKIE MEMBRANY
(2022)
Article
Fisheries
Jessica L. Norstog, Stephen D. McCormick
Summary: The life histories of anadromous and landlocked sea lamprey are similar, but landlocked populations lack exposure to seawater. This study compared the osmoregulation in juvenile sea lamprey from different populations. The results showed that all populations underwent osmoregulatory changes during metamorphosis. Survival in seawater was high in anadromous sea lamprey, but varied greatly among landlocked populations. The study also found ionoregulatory differences between the two types of lamprey, indicating relaxed selection on seawater traits and positive selection on freshwater traits in landlocked populations.
CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES
(2023)
Review
Cell Biology
V. S. Sokolov
Summary: This article reviews the investigation results of electrogenic transport by the Na+,K+-ATPase, focusing on the contribution of channel-like structures to electric current generation. A model system involving a bilayer lipid membrane with Na+,K+-ATPase-containing membrane fragments was used to study the electrogenic transport. The impedance method was applied to investigate the access channels of Na+,K+-ATPase. The review emphasizes the significant contribution of Yu.A. Chizmadzhev to the development of theoretical models for transport processes in the Na+,K+-ATPase.
BIOCHEMISTRY MOSCOW SUPPLEMENT SERIES A-MEMBRANE AND CELL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Shuyu Li, Yaomeng Huang, Tongxin Li, Xiaoran Zhu, Weimin Li, Kunshen Liu, Chao Liu
Summary: In this study, the effect of glucocorticoids on renal Na+ excretion in rats with chronic heart failure (CHF) under acute sodium loading was investigated. The results showed that glucocorticoids increased urine volume and urinary sodium, improving cardiac function and estimated glomerular filtration rate in CHF rats. These beneficial effects were associated with the downregulation of certain Na+ transporter proteins in the renal epithelium and the improvement of intrarenal hemodynamics.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Physiology
Jermaine G. Johnston, Amanda K. Welch, Brian D. Cain, Peter P. Sayeski, Michelle L. Gumz, Charles S. Wingo
Summary: Aldosterone plays a significant role in maintaining electrolyte and acid-base balance in the kidney. It is regulated by various factors and primarily acts through mineralocorticoid receptors. Abnormal secretion of aldosterone and mutations in its receptors or effectors can lead to pathologies affecting blood pressure and cardiovascular health.
COMPREHENSIVE PHYSIOLOGY
(2023)