Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 5, Pages 1201-1209Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np500077z
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Funding
- National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China [2009ZX09301-001]
- National Natural Sciences Foundation of China [30901851]
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Thirteen new dammarane-type triterpenoids (1-13) and four known analogues, gentirigenic acid (14) and the gentirigeosides A, B, and E (15-17), were isolated from Gentianella azurea. Their structures were elucidated by detailed analysis of the NMR, MS, and X-ray crystallographic data. This is the first report of dammarane-type triterpenoids in the Gentianella genus. In addition, the known structures of gentirigenic acid (14) and the gentirigeosides A, B, and E (15-17) were revised based on the X-ray diffraction analysis. Gentirigeoside A (15) was found to inhibit nitric oxide production in RAW 264.7 macrophages with an IC50 value of 6.6 +/- 2.1 mu M.
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