Journal
JOURNAL OF NATURAL PRODUCTS
Volume 78, Issue 3, Pages 396-401Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np5007718
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Funding
- NIH [S10 RR025500]
- NSF [CHE-0946779]
- University of Texas Health Science Center at Houston new faculty start-up funds
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Studies of the coprophilous fungus Hypocopra rostrata (TTI-0009, NRRL 66178) isolated from a sample of horse dung collected in Texas led to the isolation of three new sesquiterpenoids that we named hypocoprins A-C (1-3), together with the known fungal metabolite helvolic acid. The new metabolites have a distinctive ring system consisting of fused cyclopropane and cyclodecene units not previously reported from a fungal source. Compounds 1 and 3 moderately inhibited growth of Staphylococcus aureus. The structures of these metabolites were assigned mainly by analysis of 2D NMR and HRESITOFMS data. Relative and absolute configurations were assigned by interpretation of NMR J-values and NOESY data and by application of Mosher's method. These results represent the first report of chemistry from any strain of the genus Hypocopra.
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