Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 12, Pages 2489-2496Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np100874f
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Funding
- National Science Council of the Republic of China [NSC 99-2300-B-037-009]
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Bioassay-guided fractionation of the roots of Neolitsea daibuensis afforded three new beta-carboline alkaloids, daibucarbolines A-C (1-3), three new sesquiterpenoids, daibulactones A and B (4 and 5) and daibuoxide (6), and 20 known compounds. The structures of 1-6 were determined by spectroscopic analysis and single-crystal X-ray diffraction. Daibucarboline A (I), isolinderalactone (7), 7-O-methylnaringenin (8), and prunetin (9) exhibited moderate iNOS inhibitory activity, with IC50 values of 18.41, 0.30, 19.55, and 10.50 mu M, respectively.
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