Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 1, Pages 45-49Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np100606u
Keywords
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Funding
- National Natural Science Foundation of China [20972166, 31070288]
- Ministry of Education of China [B08044, MUC 98503-001006]
- Chinese Academy of Sciences
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Eight new amide alkaloids (1-8) and 19 known ones were isolated from the whole plant of Piper boehmeriaefolium. Their structures were determined through spectroscopic data analyses. Cytotoxic activity of these amides against human cervical carcinoma HeLa cells was evaluated, and 1-[(9E)-10-(3,4-methylenedioxyphenyl)-9-decenoyl]pyrrolidine (9) exhibited significant inhibitory activity with an IC50 value of 2.7 mu g/mL.
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