Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 11, Pages 2477-2481Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np200708q
Keywords
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Funding
- Science and Technology Program of Jiangsu Administration of Traditional Chinese Medicine [LZ09001]
- Priority Academic Program Development of Jiangsu Higher Education Institutions [ysxk-2010]
- Ministry of Education of China
- Program Sponsored for Scientific Innovation Research of College Graduate in Jiangsu Province [790]
- Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica [P09018]
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Three new bistetrahydrofuran annonaceous acetogenins (1-3) were isolated from a 95% EtOH extract of Annona squamosa seeds. Four known annonaceous acetogenins, uvarigrandin A (4), bullatacin (5), squamostatin-A (6), and squamostatin-D (7), were also isolated. Their structures were elucidated by spectroscopic analyses, and the absolute configurations of the carbinol centers of 1-3 were defined by application of the Mosher method. These compounds all exhibited significant cytotoxic activity in vitro against five human tumor cell lines.
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