Journal
JOURNAL OF NATURAL PRODUCTS
Volume 74, Issue 10, Pages 2174-2180Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np200499d
Keywords
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Funding
- Fogarty International Center
- National Cancer Institute
- National Science Foundation
- National Heart, Lung and Blood Institute
- National Institute of Mental Health
- Office of Dietary Supplements
- Office of the Director of NIH [U01 TW000313]
- Agricultural Food Research Initiative of the National Institute of Food and Agriculture, USDA [2008-35621-04732]
- National Science Foundation [CHE-0619382, CHE-0722638]
- International Cooperative Biodiversity Groups
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Investigation of extracts from the plant Athroisma proteiforme (Humbert) Mattf. (Asteraceae) for antimalarial activity led to the isolation of the five new sesquiterpene lactones 1-5 together with centaureidin (6). The structures of the new compounds were deduced from analyses of physical and spectroscopic data, and the absolute configuration of compound 1 was confirmed by an X-ray crystallographic study. Athrolides C (3) and D (4) both showed antiplasmodial activities with IC50 values of 6.6 (3) and 7.2 mu M (4) against the HB3 strain and 5.5 (3) and 4.2 mu M (4) against the Dd2 strain of the malarial parasite Plasmodium falciparum. The isolates 1-6 also showed antiproliferative activity against A2780 human ovarian cancer cells, with IC50 values ranging from 0.4 to 2.5 mu M.
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