Hyaluronidase Inhibitors from Cimicifugae Rhizoma (a Mixture of the Rhizomes of Cimicifuga dahurica and C. heracleifolia)

From the 80% acetone extract of Cimicifugae Rhizoma (a mixture of Cimicifuga dahurica and C. heracleifolia used medicinally), seven new fukiic acid derivatives (1-7) and a new phenylethanoid derivative (8) were isolated along with eight known compounds (9-16). Fukinolic acid (9) and cimicifugic acids A-J (10-16, 5-7) showed stronger hyaluronidase inhibitory activities than the positive control, rosmarinic acid.