Journal
JOURNAL OF NATURAL PRODUCTS
Volume 73, Issue 11, Pages 1914-1921Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np100583u
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Funding
- Natural Sciences Foundation of China (NSFC) [30825044, 20932007]
- National Science and Technology Project of China [2009ZX09301-003-4-1]
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Fourteen new abietane (1-14) and seven new C-20-norabietane (15-21) diterpenes, together with five known analogues, have been isolated from the stem bark of Fraxinus sieboldiana. Their structures were elucidated by spectroscopic data analysis. In the in vitro assays, at 10(-5) M, compounds 8, 16, and 22 showed inhibitory activity against the release of beta-glucuronidase in rat polymorphonuclear leukocytes induced by platelet-activating factor, with 59.7 +/- 4.8%, 56.1 +/- 5.6%, and 65.9 +/- 3.1% inhibition, respectively. Compound 23 was active against H5N1 avian influenza virus with an IC50 value of 4.8 mu M. Compounds 3 and 5 exhibited selective cytotoxic activities against A2780 (IC50 1.7 mu M) and A549 (IC50 6.0 mu M), respectively.
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