Phloroglucinols from the Argentine Ferns Elaphoglossum gayanum and E-piloselloides

Five new prenylated phloroglucinols were isolated from the diethyl ether extracts of the ferns Elaphoglossum gayanum and E. piloselloides. Their structures were established by analysis of their spectroscopic data (ID and 2D NMR, HRMS, and IR) and chemical derivatization. The two major compounds exhibited moderate molluscicidal activity against the snail Biomphalaria peregrina, a vector of the tropical disease schistosomiasis, with LD(50) 7.2 mu g/mL (14.4 mu M) and 11.7 mu g/mL (22.2 mu M).