Journal
JOURNAL OF NATURAL PRODUCTS
Volume 73, Issue 5, Pages 1002-1004Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np100113e
Keywords
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Funding
- Japan Society for the Promotion of Science (JSPS) [2010-2012]
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan [S0801043]
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Three novel p-terphenyl compounds, named boletopsins A (1), B (2), and C (3), and four known analogues (4-7) were isolated from fruiting bodies of the mushroom Boletopsis leucomelas. Compounds 1-7 were tested for KDR kinase inhibitory activity, and boletopsin C (3) was found to have an IC50 value of 70.7 mu M. Compound 3 also showed inhibition of proliferation of human umbilical vein endothelial cells, with an IC50 value of 9.04 mu M.
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