Journal
JOURNAL OF NATURAL PRODUCTS
Volume 73, Issue 6, Pages 1180-1183Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np100013r
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Funding
- CAPES
- CNPq
- FINEP
- FAPESP
- INCT-Project Controle Biorracional de Insetos Pragas [573742/2008-1]
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Phytochemical investigation of the bark of Guatteria hispida afforded three new alkaloids, 9-methoxy-O-methylmoschatoline (1), 9-methoxyisomoschatoline (2), and isocerasonine (3), along with 10 known alkaloids, 8-oxopseudopalmatine (4), O-methylmoschatoline (5), lysicamine (6), liriodenine (7), 10-methoxyliriodenine (8), nornuciferine (9), anonaine (10), xylopine (11), coreximine (12), and isocoreximine (13). The major compounds, 2, 6, 12, and 13, showed significant antioxidant capacity in the ORAC(FL), assay. Compounds 5, 6, and 7 were active against S. epidermidis and C. dubliniensis, with MIC values in the range 12.5-100 mu g mL(-1).
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