Journal
JOURNAL OF NATURAL PRODUCTS
Volume 73, Issue 6, Pages 1075-1079Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np100086x
Keywords
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Funding
- National Basic Research Program of China (973 Program) [200903522300]
- Chinese Academy of Sciences [KSCX2-YW-R-202]
- National Natural Science Foundation of China
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Four new bisindole alkaloids, melodinines H-K (1-4), a new monomer, melodinine L (5), and 11 known alkaloids were isolated from Melodinus tenuicaudatus. The structures of 1-5 were elucidated by extensive spectroscopic methods, and the known compounds were identified by comparison with data in the literature. All of the compounds were evaluated for their cytotoxicity against five human cancer cell lines, Alkaloids 3, and 4 and the known compound 11-methoxytabersonine (8) exhibited inhibitory effects, with IC50 values comparable to those of cisplatin and vinorelbine.
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