Article
Plant Sciences
Ha Gao, Chen-Xu Zhao, Xin-Yao Luo, Jing-Rong Li, Xiao-Chuan Ye, Tao Zhang, Zhong-Mei Zou
Summary: Four new glycosides, along with six known compounds, were isolated from the whole plant of Gerbera piloselloides. Their structures and absolute configurations were determined using extensive spectroscopic data and X-ray diffraction analysis. Among them, compounds 3 and 4 showed moderate promotion of proliferation in lipopolysaccharide-induced intestinal epithelial cells.
PHYTOCHEMISTRY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Jia Zhang, Ya-Nan Yang, Jian-Shuang Jiang, Zi-Ming Feng, Xiang Yuan, Xu Zhang, Pei-Cheng Zhang
Summary: Five new dimeric phloroglucinol derivatives, agrimones A-E (1-5), were isolated from Agrimonia pilosa. Their structures and absolute configurations were determined through a series of spectroscopic data, and compounds 1 and 2 exhibited a unique highly oxidized tricyclic ring skeleton. Additionally, compounds 1a, 4, and 5 showed moderate hepatoprotective activities against APAP-induced HepG2 cell injury.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Chenxu Zhao, Ha Gao, Jingrong Li, Meng Yu, Jiangping Wu, Haixin Zhang, Tao Zhang, Zhongmei Zou
Summary: This study identified several previously undescribed compounds from the extract of Gerbera piloselloides, including some that showed inhibitory effects on nitric oxide production and cancer cell proliferation.
Article
Chemistry, Medicinal
Xing Peng, Qingyun Tan, Huihao Zhou, Jun Xu, Qiong Gu
Summary: Thirteen phloroglucinols were isolated from Hypericum japonicum, with compounds 2-3 showing significant inhibitory effects on ferroptosis induced by RSL3. This study highlights the potential anti-ferroptosis activity of phloroglucinols as a promising strategy for treating neurological diseases.
Article
Plant Sciences
Dale W. Prebble, Darren C. Holland, Francesca Ferretti, Joshua B. Hayton, Vicky M. Avery, George D. Mellick, Anthony R. Carroll
Summary: The study suggests a potential link between amyloid protein aggregation and the progression of neurodegenerative conditions and malaria. By screening antiplasmodial active extracts from Australian eucalypt flowers, researchers discovered a compound (Myrtucommulone P) that not only showed affinity to a Parkinson's disease-implicated protein but also exhibited antiplasmodial activity and inhibited protein aggregation. In addition, several other compounds were isolated from E. cloeziana.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Plant Sciences
Odeta Celaj, Alexandra G. Duran, Pasqualina Cennamo, Monica Scognamiglio, Antonio Fiorentino, Assunta Esposito, Brigida D'Abrosca
Summary: Myrtaceae plants are rich in bioactive compounds, especially acylphloroglucinols and phloroglucinol-terpene adducts. These compounds exhibit unique biological activities and have attracted interest from organic chemists for further study and synthesis techniques.
PHYTOCHEMISTRY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Nguyen Viet Phong, Vu Thi Oanh, Seo Young Yang, Jae Sue Choi, Byung Sun Min, Jeong Ah Kim
Summary: This study isolated 30 phloroglucinols from Dryopteris crassirhizoma and identified trimeric phloroglucinols 26-28 as potent inhibitors of PTP1B, suggesting their potential for treating type 2 diabetes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Sumana Bhowmick, Manfred Beckmann, Jianying Shen, Luis A. J. Mur
Summary: This study confirms the authenticity of Dryopteris crassirhizoma and evaluates its antimicrobial activities. The results show that the extracts of Dryopteris crassirhizoma exhibit significant antimicrobial activities against methicillin-resistant Staphylococcus aureus (MRSA). Further fractionation and characterization identify a fraction enriched with two anti-MRSA compounds, with norflavaspidic acid AB showing unique effects on MRSA cells' bioenergetic transformation and metabolism. This study may have discovered a naturally available compound that could help counter clinically relevant strains with antibiotic resistance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fan Quan, Xinbo Luan, Jian Zhang, Wenjie Gao, Jian Yan, Ping Li
Summary: The aim of this study was to identify bioactive compounds from different plant parts of G. xanthochymus and it was found that the seed extract exerted significant cytotoxic effects on five human cancer cell types. LC-MS-based metabolomics analysis was used to identify potential markers and isolate new compounds.
Article
Biochemistry & Molecular Biology
Ruifei Zhang, Zhuo Cheng, Qiong Fang, Edward J. Kennelly, Chunlin Long
Summary: Hypericum species (Hypericaceae) are important plants with medicinal, edible, and ornamental values. A study on H. hengshanense led to the discovery and characterization of 25 monoterpenoid acylphloroglucinols (MAPs), including 10 undescribed compounds. The structures were determined using UV, HR-ESI-MS, and NMR, while the absolute configurations were determined through ECD analysis. Furthermore, several compounds exhibited broad-spectrum antiproliferative activities against various human cell lines.
Article
Biochemistry & Molecular Biology
E-E Luo, Si-Na Liu, Zhao-Jie Wang, Ling-Yun Chen, Cheng-Qin Liang, Mu-Yuan Yu, Xu-Jie Qin
Summary: A series of phloroglucinol oligomers with anti-AD and antibacterial activity were isolated from the leaves of Rhodomyrtus tomentosa, among which phloroglucinol dimers 3a and 3b showed the most potent human acetylcholinesterase inhibitory activity and could destroy the biofilm structures of MRSA.
BIOORGANIC CHEMISTRY
(2023)
Article
Food Science & Technology
Anne B. Carlson, Carey A. Mathesius, Stephen Ballou, Melissa N. Fallers, Tim A. Gunderson, Aideen Hession, Henry Mirsky, Brian Stolte, John Zhang, Rachel M. Woods, Rod A. Herman, Jason M. Roper
Summary: This article presents the hazard identification and characterization studies of the insecticidal protein IPD079Ea derived from a fern plant for controlling the maize pest. The results indicate that IPD079Ea is safe for human and animal health, further supporting the safety of genetically modified maize expressing this protein.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Chemistry, Applied
Ritesh Raju, Shintu Mathew, Ahilya Singh, Paul Reddell, Gerald Munch
Summary: Two new phloroglucinols, acronyols A (1) and B (2), along with four known phloroglucinols (3-6) were identified from the fruits of Acronychia crassipetala. These compounds were evaluated for their inhibitory effects on NO production and downregulation of TNF-alpha in RAW 264.7 macrophage cell lines, showing promising anti-inflammatory activities.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Jie Wang, Jian-Guo Song, Dong-Lin Zhong, Zhi-Zhang Duan, Zi-Jian Peng, Wei Tang, Qiao-Yun Song, Xiao-Jun Huang, Li-Jun Hu, Ying Wang, Wen-Cai Ye
Summary: A synthetic strategy based on biogenetic building blocks has been developed for the biomimetic synthesis of cleistoperlones A-F. The syntheses involve cascade reactions and rare cycloaddition reactions for the construction of complex structures. Cleistoperlone A exhibits significant antiviral activity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Heung Joo Yuk, Ji-Yul Kim, Yoon-Young Sung, Dong-Seon Kim
Summary: The rhizomes of Dryopteris crassirhizoma contain potent xanthine oxidase inhibitory compounds, with flavaspidic acid AP showing the strongest inhibitory activity. These inhibitors exhibit reversible and noncompetitive inhibition towards xanthine oxidase.
