Journal
JOURNAL OF NATURAL PRODUCTS
Volume 72, Issue 3, Pages 503-506Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np800732n
Keywords
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Funding
- National Cancer Institute, National Institutes of Health [NOI-CO-12400]
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Several quassinoids were identified in a high-throughput screening assay as inhibitors of the transcription factor AP-1. Further biological characterization revealed that while their effect was not specific to AP-1, protein synthesis inhibition and cell growth assays were inconsistent with a mechanism of simple protein synthesis inhibition. Numerous plant extracts from the plant family Simaroubaceae were also identified in the same screen; bioassay-guided fractionation of one extract (Ailanthus triphylla) yielded two known quassinoids, ailanthinone (3) and glaucarubinone (4), which were also identified in the pure compound screening procedure.
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