Article
Chemistry, Medicinal
Fang-You Chen, Wan-Wan Yu, Ji-Wu Huang, Wei-Ming Huang, Yu-Ting Bian, Peng-Cheng Shuang, Yong-Ming Luo
Summary: Seven eudesmane-type sesquiterpenoids were isolated from the roots of Chloranthus serratus, including racemic compounds and a sesquiterpenoid lactone. Compounds 1b and 4 showed neuroprotective effects on H2O2 damaged PC12 cells, enhancing cell viability significantly at 10μM concentration.
Article
Chemistry, Applied
Xue-Jiao Wang, Jun-Li Xin, Sheng-Zhou Yu, Li-Long Pan, Jin-Feng Hu, Juan Xiong
Summary: Two new eudesmanolide-type enantiomers and thirteen known sesquiterpenoids were isolated from Chloranthus henryi var. hupehensis, along with the determination of their absolute configurations. The inhibitory activities of these compounds against LPS-induced NO production in murine BV-2 microglial cells were evaluated, and two dimeric sesquiterpenoids showed the most potent activities.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Medicinal
Fang-You Chen, Wan-Wan Yu, Feng-Xiang Lin, Ji-Wu Huang, Wei-Ming Huang, Peng-Cheng Shuang, Yu-Ting Bian, Yong-Ming Luo
Summary: Three rare sesquiterpenoids with unique structures were isolated from the roots of Chloranthus henryi, showing moderate neuroprotective activities on PC12 cells damaged with hydrogen peroxide through experimental studies.
Article
Biochemistry & Molecular Biology
Wei-ming Huang, Yu-ting Bian, Fang-you Chen, Tian-jiao Ning, Zhi-ying Zhu, Zhi-chao Chen, Yong-ming Luo
Summary: This study isolated twelve undescribed sesquiterpenoids and four known compounds from Chloranthus multistachys. The structures of the undescribed compounds were determined using spectroscopic techniques and crystallography. Some of these compounds exhibited moderate anti-inflammatory activities.
Article
Chemistry, Multidisciplinary
Zhao-Chun Zhan, Zhong-Nan Wu, Qing Tang, Can-Jie Li, Wen-Zhi Wang, Ji-Hui Zhang, Xue-Fang Zhuo, Yu-Bo Zhang, Guo-Cai Wang, Yao-Lan Li
Summary: Five new sesquiterpenoids and three known compounds were isolated from Chloranthus holostegius. Compound 4 demonstrated the most significant anti-inflammatory activity, better than dexamethasone.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Article
Plant Sciences
Yuting Bian, Fangyou Chen, Weiming Huang, Zhichao Chen, Pengcheng Shuang, Yongming Luo
Summary: Two new compounds (1 and 2) along with eight known sesquiterpenes (3-10) and six other known compounds (11-16) were isolated from the whole plant of Chloranthus henryi. The structures and absolute configurations of the new compounds were determined using HR-ESI-MS, NMR spectroscopic, and X-ray crystallography. These compounds were reported for the first time from this species.
RECORDS OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Multidisciplinary
Rong Lin, Ronghao Sun, Ting Xiao, Suyu Pei, Qiang Zhang, Yexin Cheng, Xiaowei Guo, Zhongyi Yang, Xiaoting Gu, Fubo Zhang, Chunfeng Xie, Cheng Yang
Summary: A new phenylpropenol ester and three new lindenane sesquiterpenes were isolated from Chloranthus japonicus, and one of the compounds showed moderate efficacy in inhibiting cell migration and vasculogenic mimicry in human hepatocarcinoma cells, possibly by altering protein expression and restraining epithelial-mesenchymal transition.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Dan-Yang Zhang, Yun-Ran Hu, Hui Yang, Ya-Nan Wang, Shuai Liu, Yun-He Zou, Jing-Jing Zhou, Peng-Yu Zhuang, Xiao-Xia Wang, Hang Liu
Summary: In this study, 27 new sesquiterpenoids, including twenty monomers and seven dimers, were isolated from Chloranthus henryi var. hupehensis. Among them, chlorahupetolides A and B, two eudesmane-type merosesquiterpenoids, and chlorahupetene E, a dimer bridged by a four-membered ring, were identified as the first examples in Chloranthus. The compounds 12, 18, and 25 exhibited dose-dependent inhibition of NO production and COX-2 mRNA expression in the LPS-induced RAW264.7 macrophages model, without cytotoxicity.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Plant Sciences
Xiao-Yu Xie, Yi-Xuan Yang, Xin Gao, Qian Liu, Zi-Han Liu, Xiao-Feng Niu, Xia Liu
Summary: New dinor-eudesmane sesquiterpenoids were isolated from the root extract of Chloranthus multistachys Pei, and their structures were elucidated through spectroscopic analysis. The cytotoxicity activities of the compounds against selected cancer cells were evaluated through MTT assay.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Shuai Liu, Zi-Mo Zhang, Hui Yang, Yun-He Zou, Ning Wang, Peng-Yu Zhuang, Xiao-Xia Wang, Hang Liu
Summary: Phytochemical research on Chloranthus henryi Hemsl. var. hupehensis revealed the presence of twenty-three terpenoids, including twenty-two sesquiterpenoids and one diterpenoid. Extensive spectroscopic analysis and comparison with literature data were used to identify their structures. Some of the compounds were isolated for the first time from the family Chloranthaceae and the genus Chloranthus. The chemotaxonomic significance of the constituents was also discussed.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dan-Yang Zhang, Xiao-Xia Wang, Min Wang, Bai-Lin Su, Ya-Xin Wang, Jin-Yu Li, Jing Yi, Peng-Yu Zhuang, Hang Liu
Summary: Seventeen compounds were isolated from the aerial parts of Chloranthus henryi Hemsl. var. hupehensis (Pamp.) K. F. Wu, including five new compounds. The chemical structures of these compounds were elucidated through extensive spectroscopic and chemical analyses. The isolated compounds have significant chemotaxonomic implications.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2021)
Article
Medicine, Research & Experimental
Shuping Sun, Yunyan Du, Shengli Li, Bianbian Gao, Rongping Xia, Wenjing Cao, Chao Zhang, Enze Zhu
Summary: The study demonstrated that extracts of Chloranthus serratus possess significant anti-inflammatory and protective effects on adjuvant-induced arthritis in rats, with the water isolated site showing the most remarkable effect, possibly through oxidative stress and inhibition of inflammatory factors.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Plant Sciences
Shuping Sun, Jiahao Zhang, Hongxing Li, Yunyan Du, Shengli Li, Anqi Li, Xiaoguo Suo, Yang Wang, Qi Sun
Summary: The study found that the water extract of Chloranthus serratus roots exerts its anti-inflammatory activity by inhibiting the MAPK and NF-kappa B pathways, activating the Nrf2/HO-1 pathway, and dose-dependently regulating the levels of inflammatory factors.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Organic
Jun-Su Zhou, Qun-Fang Liu, Flavia M. Zimbres, Joshua H. Butler, Maria B. Cassera, Bin Zhou, Jian-Min Yue
Summary: Four new lindenane sesquiterpenoid trimers, named trichloranoids A-D (1-4), were isolated from Chloranthus spicatus, along with a known analogue (5). Their structures were determined through various methods, including DP4+ probability and TDDFT-ECD calculations. Compounds 1 and 2 each contained a unique skeletal unit in their western hemisphere, likely formed biogenetically via a biradical rearrangement of the vinylcyclopropane. Compounds 1, 4, and 5 showed moderate antimalarial activities.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Plant Sciences
Jun-Su Zhou, Su-Ling Huang, Yuan Gao, Qun-Fang Liu, Ying Leng, Bin Zhou, Jian-Min Yue
Summary: Seven new phenolic-monoterpenoid hybrid molecules, Spicatulides A-G (1-7), along with two known compounds (8 and 9), were isolated and identified from Chloranthus spicatus. Compound 1 possesses a novel skeleton with an aryl-fused 2-oxabicyclo[4.3.1]decane moiety, while compound 2 is the first reported denudaquinol-normonoterpenoid adduct. Spectroscopic data analyses and TDDFT-ECD calculations were used to determine the structures and absolute configurations of these compounds. Compounds 3, 5, 6, and 9 showed dose-dependent activity in reducing lipogenesis in HepG2 cells.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Plant Sciences
You-Sheng Cai, Ariel M. Sarotti, Ting-Lan Zhou, Rong Huang, Guofu Qiu, Congkui Tian, Ze-Hong Miao, Attila Mandi, Tibor Kurtan, Shugeng Cao, Sheng-Ping Yang
JOURNAL OF NATURAL PRODUCTS
(2018)
Article
Chemistry, Medicinal
Li Rao, Yun-Xia You, Yu Su, Yu Liu, Qian He, Yue Fan, Feng Hu, You-Kai Xu, Chuan-Rui Zhang
Article
Chemistry, Medicinal
Yue Fan, Yu Liu, Yun-Xia You, Li Rao, Yu Su, Qian He, Feng Hu, Yizhou Li, Weili Wei, You-Kai Xu, Bin Lin, Chuan-Rui Zhang
Article
Biochemistry & Molecular Biology
Wei Li, Li Rao, Yu Liu, Qian He, Yue Fan, Yun-Xia You, Yu Su, Feng Hu, You-Kai Xu, Bin Lin, Sheng Yin, Chuan-Rui Zhang
BIOORGANIC CHEMISTRY
(2019)
Article
Plant Sciences
You-Sheng Cai, Cong Wang, Congkui Tian, Wen-Tin Sun, Ling Chen, Di Xiao, Si-Yuan Zhou, Guofu Qiu, Jianqing Yu, Kongkai Zhu, Sheng-Ping Yang
JOURNAL OF NATURAL PRODUCTS
(2019)
Article
Agriculture, Multidisciplinary
Li Rao, Yun-Xia You, Yu Su, Yue Fan, Yu Liu, Qian He, Yi Chen, Jie Meng, Lin Hu, Yizhou Li, You-Kai Xu, Bin Lin, Chuan-Rui Zhang
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2020)
Article
Plant Sciences
Hong-Yan Xu, Ji-Hua Ren, Yu Su, Fang Ren, Yu-Jiao Zhou, Hui Jiang, Sheng-Tao Cheng, Chuan-Rui Zhang, Juan Chen
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Chemistry, Applied
Qian He, Yue Fan, Yu Liu, Yun-Xia You, Li Rao, Yu Su, You-Kai Xu, Bin Lin, Chuan-Rui Zhang
Summary: Five new alpha-pyrone derivatives, cryptoyunnanes A-E (1-5), along with four known analogues, were isolated from Cryptocarya yunnanensis. Compounds 4 and 6 exhibited significant cytotoxicity against various cancer cell lines, while compounds 1, 2, and 7 also showed good cytotoxicity. This study represents the first report on the isolation and bioactivity evaluation of chemical constituents from C. yunnanensis.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yu-Xi Chen, Yun-Xia You, Li Rao, Yu Liu, Qian He, You-Kai Xu, Bin Lin, Chuan-Rui Zhang
Summary: In this study, two new neolignans and a new sesquiterpenoid were isolated from Piper yunnanense, featuring rare structural characteristics. Their antimicrobial and cytotoxic activities were evaluated against various bacteria, fungi, and human cancer cell lines.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Plant Sciences
Li Rao, Yao Li, Qian He, Yu Liu, Yu Su, Yun-Xia You, Yue Fan, Bin Lin, Yi-Nan Zhang, Chuan-Rui Zhang
Summary: In this study, eleven new iridoids, brachybones A-K (1-11), were isolated from the twigs of Viburnum brachybotryum. The structures of the compounds were determined through spectroscopic data analysis and electronic circular dichroism (ECD) spectra. Compounds 10 and 11 were found to exhibit cytotoxic activity against HCT-116 cells.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Plant Sciences
Qian He, Yue Fan, Yu Liu, Li Rao, Yun-Xia You, Yu Su, Zhen Zhou, You-Kai Xu, Chuan-Rui Zhang
Summary: Eight new complex flavanones with a novel linkage, cryptoyunnanones A-H (1-8), were isolated from Cryptocarya yunnanensis leaves and twigs, along with four known alpha-pyrones. Compounds 1-4 exhibited cytotoxicity against cancer cells.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Chemistry, Medicinal
Xi Wang, Fuqian Wang, Jun Wu, Shun-Qing Chen, Cheng-Shi Jiang, Sheng-Ping Yang, Cong Wang, You-Sheng Cai
Summary: Novel and known Lycopodium alkaloids were isolated and identified from Lycopodium japonicum Thunb., but unfortunately, all compounds showed no significant inhibitory effects on acetylcholinesterase and alpha-glucosidase.
Article
Biochemistry & Molecular Biology
Yu Su, Wanbin Song, Qian He, Yue Fan, Li Rao, Yu Liu, Yinan Zhang, Chuan-Rui Zhang
Summary: Two new flavonoids, cryunchalcone (1) and cryptoyunnanone I (2), have been isolated from the leaves and twigs of Cryptocarya yunnanensis. Cryunchalcone (1) is a biflavonoid formed by a dihydrochalcone linked with a chalcone, while cryptoyunnanone I (2) is a unique complex flavanone with a phenylpropanoid moiety.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Plant Sciences
Qian He, Simin Li, Yue Fan, Yu Liu, Yu Su, Zhen Zhou, Yi-Nan Zhang, Guo-Li Li, Li Rao, Chuan-Rui Zhang
Summary: Nine new complex flavanones, named cryptometcones A-I (1-9), along with four known analogues, were isolated from Cryptocarya metcalfiana. Their structures and absolute configurations were determined through spectroscopic data analysis and ECD calculations. Compounds 3-5, 8, and 9 exhibited cytotoxicity against the HCT-116 cancer cell line.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Shun-Qing Chen, Jia Jia, Jing-Yao Hu, Jun Wu, Wen-Ting Sun, Mingxin Zheng, Xi Wang, Kong-Kai Zhu, Cheng-Shi Jiang, Sheng-Ping Yang, Juan Zhang, Shou-Bao Wang, You-Sheng Cai
Summary: Phytochemical investigation on the aerial parts of Tabernaemontana bufalina Lour. led to the identification of several new alkaloids and known indole alkaloids. The structures and absolute configurations of the new alkaloids were determined by spectroscopic and computational methods. Some of these alkaloids exhibited significant bioactivity, demonstrating potential for drug development.
