Journal
JOURNAL OF NATURAL PRODUCTS
Volume 71, Issue 11, Pages 1902-1905Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np8004166
Keywords
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Funding
- Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT)
- NCET Foundation
- NSFC [30725045]
- National 863 Program [2006AA02Z338]
- China Postdoctoral Science Foundation [20070410711]
- 973 Program of China [2007CB507400]
- Shanghai Leading Academic Discipline Project [13906]
- Scientific Foundation of Shanghai China [07DZ19728, 06DZ19717, 06DZ19005]
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Chemical examination of the methanolic extract from the stem bark of Daphne feddei led to the isolation of five new phenylpropanoids, 4,4'-dihydroxy-3,3'-dimethoxy-9-butoxy-9,9'-epoxylignan (1), 4,4'-dihydroxy-3,3'-dimethoxy-9-ethoxy9,9'-epoxylignan (2), daphneresinol (3), armaosigenin (4), and isocubebin (5), together with 33 known phenylpropanoids. All 38 compounds were isolated for the first time from D. feddei. All compounds were tested for inhibitory activity against LPS-induced NO production in RAW 264.7 macrophages. Compounds 2, 8, 9, 12, 13, and 15 showed potent inhibitory activities against the production of NO with IC50 values of 0.091, 0.047, 0.005, 0.088, 0.004, and 0.074 mu M/mL, respectively.
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