Article
Agriculture, Multidisciplinary
Qi Zhuang, Shuangshuang Chen, Wei Zhang, Minhui Gu, Long Xiao, Yajun Li, Yunshang Yang, Chengcheng Feng, Hong Li, Dechun Geng, Zhirong Wang
Summary: Osteoporosis is characterized by bone loss and degeneration, leading to an increased risk of fractures and impacting the health of middle-aged and elderly individuals. Drug therapy, the main treatment for osteoporosis, is limited in efficacy and often associated with side effects. Therefore, developing new, effective, and safe treatment methods is crucial. Avicularin, a flavonoid derivative, was shown to disrupt osteoclast activation and resorptive function, preventing their activity. It achieved this by inhibiting the NF-kappa B pathway and downregulating osteoclast-related genes. Treatment with Avicularin also improved bone mineral density in an osteoporosis mouse model.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Oncology
Yoshihiro Araki, Hisaki Aiba, Takeshi Yoshida, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Tuan D. Nguyen, Kiyo-aki Ishii, Takayuki Nojima, Satoru Takahashi, Hideki Murakami, Hiroyuki Tsuchiya, Rikinari Hanayama
Summary: The study found that osteosarcoma-derived small extracellular vesicles enhance distant metastasis by inhibiting osteoclast maturation, which may serve as a useful prognostic marker. Lower numbers of osteoclasts in biopsy specimens at the first visits in osteosarcoma patients were correlated with higher malignancy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Dahu Qi, Hui Liu, Xuying Sun, Danni Luo, Meipeng Zhu, Tenghui Tao, Chenghao Gao, Chuankun Zhou, Wei Zhou, Jun Xiao
Summary: Pristimerin exerts potential therapeutic effects on osteoporosis by inhibiting NF-kappa B and MAPK signaling pathways, reducing ROS production, activating Nrf2/HO-1 signaling pathway, and affecting osteoclast differentiation and function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Melis Olcum, Kemal Ugur Tufekci, Devrim Yagmur Durur, Bora Tastan, Irem Nur Gokbayrak, Kursad Genc, Sermin Genc
Summary: Ethyl pyruvate has anti-inflammatory and pro-metabolic effects, effectively suppressing NLRP3 inflammasome activation in microglial cells by regulating miR-223 and the NF-κB/HMGB1 axis.
Article
Biochemistry & Molecular Biology
Meipeng Zhu, Qian Guo, Honglei Kang, Renpeng Peng, Yimin Dong, Yayun Zhang, Sibo Wang, Haiyang Liu, Hongjian Zhao, Zijian Dong, Kehan Song, Shimeng Xu, Pengju Wang, Liangxi Chen, Jian Liu, Feng Li
Summary: Fatty amide hydrolase (FAAH) is involved in various biological processes and may play an important role in osteoclastogenesis. Inhibition of FAAH in bone marrow-derived macrophages (BMMs) suppressed osteoclastogenesis and bone resorption. The FAAH inhibitor PF-04457845 improved bone loss in mice, and its effects were mediated through the NF-kappa B and MAPK pathways. Targeting FAAH may be a promising strategy for treating osteoclast-related diseases, particularly osteoporosis.
Article
Nutrition & Dietetics
Mak-Soon Lee, Jumi Lee, Yangha Kim
Summary: This study aimed to investigate the effects of green tea extract containing Piper retrofractum fruit on dextran-sulfate-sodium induced colitis and its regulatory mechanisms. The results showed that the green tea extract treatment alleviated clinical symptoms of colitis and suppressed miR-21 expression and NF-kappa B activity, indicating its potential as a functional material for improving colitis.
Article
Cell Biology
Yongxian Li, Sipeng Lin, Panjie Liu, Jianbin Huang, Junxiong Qiu, Zhenkang Wen, Jinbo Yuan, Heng Qiu, Yuhao Liu, Qian Liu, Tengpeng Zhou, Peijie Luo, Huizhi Guo, Yanhuai Ma, Danqing Guo, Guoye Mo, Yongchao Tang, Liangliang Xu, De Liang, Jiake Xu, Yue Ding, Shuncong Zhang
Summary: The study found that Carnosol has a strong inhibitory effect on osteoclast differentiation induced by RANKL, potentially serving as a therapeutic supplementary in the prevention or treatment of osteolysis by suppressing the formation and function of RANKL-induced osteoclasts.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Fabiola Olivieri, Francesco Prattichizzo, Angelica Giuliani, Giulia Matacchione, Maria Rita Rippo, Jacopo Sabbatinelli, Massimiliano Bonafe
Summary: Inflammaging is a key concept in understanding how aging contributes to the development of age-related diseases, with a focus on the role of miRNAs in regulating inflammatory pathways. The assessment of individual genetic make-up alone is insufficient to depict the trajectories of age-related inflammation, and studies have shown that circulating inflammamiRs could be used to measure the degree of inflammaging.
AGEING RESEARCH REVIEWS
(2021)
Article
Medicine, Research & Experimental
Qi Yu, Qianqian Li, Xinglong Yang, Qiang Liu, Jun Deng, Yanping Zhao, Ruilin Hu, Min Dai
Summary: The study demonstrated that Dex inhibits AAA development by downregulating the miR-21/PDCP4 axis, revealing a potential novel treatment approach for AAA. The high expression of miR-21 and its targeting of PDCD4 were found to be closely related to the development and inflammatory responses of AAA.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Guobin Qi, Zengxin Jiang, Wei Lu, Defang Li, Weibing Chen, Xiuying Yang, Lei Ding, Hengfeng Yuan
Summary: Berbamine, a natural product from Berberis amurensis Rupr, was found to have a protective effect against osteoporosis by inhibiting osteoclastogenesis and bone resorption without affecting osteogenesis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Mengbo Zhu, Wenbin Xu, Jiuzhou Jiang, Yining Wang, Yanjing Guo, Ruijia Yang, Yaqiong Chang, Bin Zhao, Zhenyu Wang, Jianfeng Zhang, Te Wang, Liqin Shangguan, Shaowei Wang
Summary: The study found that peiminine can inhibit the differentiation and function of OCs by regulating the levels of specific genes and proteins, with potential targets including NF-kappa B and ERK1/2 signaling pathways. In an animal model, peiminine can alleviate bone loss in ovariectomized mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Chang-hong Li, Zhen-zhen Ma, Lei-lei Jian, Xin-yu Wang, Lin Sun, Xiang-yuan Liu, Zhong-qiang Yao, Jin-xia Zhao
Summary: Iguratimod has been shown to inhibit osteoclast formation and bone resorption by interfering with signaling pathways, preventing bone loss in animal models. It also dampened TNF-alpha-induced osteoclastogenesis and disrupted nuclear translocation, providing promising evidence for its therapeutic application against RA and bone loss prevention.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Fangxue Zhang, Xiaowei Huang, Yuhan Qi, Zhi Qian, Shuo Ni, Zeyuan Zhong, Xu Zhang, Dejian Li, Baoqing Yu
Summary: The study demonstrated that Juglanin could inhibit osteoclast differentiation by suppressing NFATc1 activity. Further animal experiments showed that Juglanin attenuated bone loss in mice with removed ovaries by suppressing osteoclast function. Overall, Juglanin may play a vital role in preventing postmenopausal osteoporosis by inhibiting the RANKL-induced NF-kappa B signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiaodi Zhang, Zhengfang Sun, Ying Zhang, Liuzhu Pan, Wei Jiang, Hui Dong, Zhengxin Jin, Jianning Kang, Ronghan Liu, Bin Ning
Summary: This study demonstrates that Periplocin can reduce inflammation and attenuate bone resorption in osteoporosis by inhibiting MAPK and NF-kappa B signaling pathways. It also exerts anti-inflammatory and anti-osteoclastic effects by binding to LRP4. These findings provide new possibilities for the treatment of osteoporosis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ziyu Wang, Zijian Li, Guojue Wang, Ying Sun, Yuanyang Yuan, Hong Nie
Summary: Salubrinal treatment in CIA mice effectively reduces clinical scores, inhibits joint damage, and decreases the expression of destruction-related genes, showcasing its potential as a drug for RA and other bone destruction-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Vishal Panchariya, Vishal Bhati, Harishkumar Madhyastha, Radha Madhyastha, Jagdish Prasad, Priyal Sharma, Paras Sharma, Harish, Mahesh Kumar Saini, Vishnu D. Rajput, Yuichi Nakajima, S. L. Kothari, Vinod Singh Gour
Summary: This study optimized a decolorization protocol for a biosurfactant derived from the mesocarp of Balanites aegyptiaca, and investigated its hemolytic potential and biocompatibility. Results showed that 1.5% hydrogen peroxide can efficiently decolorize the biosurfactant at 40 degrees C in 70 min, with no significant toxic effects on M5S skin fibroblast cells up to 50 mu g/mL for 6 h. The biosurfactant also showed minimal hemolysis of human RBCs, confirming its non-toxic nature.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Jayasindu Mathiyazhagan, Ramamoorthy Siva, Rama Jayaraj, Harishkumar Madhyastha, Gothandam Kodiveri Muthukaliannan
Summary: The study found that the Zingiber officinale-Terminalia chebula extract (ZOTC) has a suppressive effect on tumor progression in DMBA-induced breast cancer rats, potentially through the inhibition of the mTOR pathway.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Bethasiwi Purbasari, Radha Madhyastha, Harishkumar Madhyastha, Queen Intan Nurrahmah, Masugi Maruyama, Yuichi Nakajima, Hiroaki Kataoka, Nozomi Watanabe
Summary: The study found that carbachol induces NLRP3 inflammasome activation through mAChR and NF-kappa B, while RA abolishes the inflammatory response. The co-administration of RA with cholinergic drugs may have the potential to prevent inflammatory responses during cholinergic medication.
PHARMACOLOGICAL REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Kaviyarasi Renu, Sathishkumar Vinayagam, Harishkumar Madhyastha, Radha Madhyastha, Masugi Maruyama, Shubhankar Suman, Sankarganesh Arunachalam, Balachandar Vellingiri, Abilash Valsala Gopalakrishnan
Summary: Cardiotoxicity caused by the antineoplastic drug doxorubicin is associated with impaired PPAR alpha and disrupted lipid metabolism in the heart, leading to cardiac dysfunction.
CARDIOVASCULAR TOXICOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Mamta Kumawat, Harishkumar Madhyastha, Akhela Umapathi, Mandeep Singh, Neerish Revaprasadu, Hemant Kumar Daima
Summary: The study introduces a method of synthesizing gold nanoparticles using curcumin, and developing nanoparticles with peroxidase-mimicking properties by using isoniazid, tyrosine, and quercetin in the corona. These nanoparticles show excellent free radical scavenging ability and hemo- and biocompatibility. Additionally, the engineered gold nanoparticles are capable of suppressing key pro-inflammatory cytokines.
Review
Biotechnology & Applied Microbiology
Gourvi Kumari, Kumar Abhishek, Sneha Singh, Afzal Hussain, Mohammad A. Altamimi, Harishkumar Madhyastha, Thomas J. Webster, Abhimanyu Dev
Summary: Recent advancements in biomedical tissue engineering, specifically 4D printing and bioprinting, have opened new possibilities for tissue regeneration, organ regeneration, and early diagnosis of deadly diseases. This review primarily focuses on the clinical applications of these technologies for early disease detection and drug delivery.
Review
Biotechnology & Applied Microbiology
Gourvi Kumari, Kumar Abhishek, Sneha Singh, Afzal Hussain, Mohammad A. Altamimi, Harishkumar Madhyastha, Thomas J. Webster, Abhimanyu Dev
Summary: The transition from 3D to 4D printing has revolutionized various domains, adding a time-dependent response. This review discusses the significance, demands, smart materials/biomaterials, bioinks, and printers used in 4DP technology. It also explores the limitations and challenges in bioprinting processes and bioinks. The future potential of 4D printing is briefly discussed.
Review
Green & Sustainable Science & Technology
Anirban Goutam Mukherjee, Kaviyarasi Renu, Abilash Valsala Gopalakrishnan, Vishnu Priya Veeraraghavan, Sathishkumar Vinayagam, Soraya Paz-Montelongo, Abhijit Dey, Balachandar Vellingiri, Alex George, Harishkumar Madhyastha, Raja Ganesan
Summary: Heavy metal and metalloid poisoning in the environment and food, such as cadmium, lead, mercury, tin, manganese, aluminium, arsenic, antimony, and selenium, poses a severe threat to human health and ecological system. Accurate detection of even trace quantities of these toxic elements is of utmost importance to understand their risk. Several traditional and advanced technologies, including atomic absorption spectrometry (AAS), spectrofluorimetry, inductively coupled plasma spectrometry, e-tongues, electrochemical aptasensors, Raman spectroscopy, and fluorescence sensors, have proven highly beneficial in quantifying these elements in food and dietary supplements.
Review
Immunology
Hafiza Padinharayil, Reema Rose Alappat, Liji Maria Joy, Kavya V. Anilkumar, Cornelia M. Wilson, Alex George, Abilash Valsala Gopalakrishnan, Harishkumar Madhyastha, Thiyagarajan Ramesh, Ezhaveni Sathiyamoorthi, Jintae Lee, Raja Ganesan
Summary: Despite progress in understanding the progression, risk, immunologic control, and treatment choices of lung cancer, it remains the leading cause of cancer-related death. Lung cancer cells have low and heterogeneous antigenicity, allowing them to evade immune defenses. Immune checkpoint inhibitors (ICIs) are a promising therapy, but there is a need for new predictive biomarkers. A multi-parameter analysis of the immune system considering tumor, stroma, and beyond may be a future-oriented predictive marker.
Article
Biochemistry & Molecular Biology
Harishkumar Madhyastha, Radha Madhyastha, Eshika Chakraborty, Kaushita Banerjee, Kamal Shah, Yuichi Nakajima, Nagendra Singh Chauhan, Sajitha Lulu Sudhakaran, Kaoru Ohe, Gothandam Kodiveri Muthukaliannan, Abilash Valsala Gopalakrishnan, Masugi Maruyama, Nozomi Watanabe
Summary: There is a high demand for the development of nanomedicine for wound tissue regeneration with silver doped nanoceuticals. However, little research has been done on antioxidants-doped silver nanometals and their interaction during the bio-interface mechanism. This study prepared and analyzed c-phycocyanin primed silver nano hybrids (AgcPCNP) for their properties and their effects on gene expression and cell migration in wound healing scenarios. The results showed that AgcPCNP can accelerate fibroblast cell migration and has potential for wound healing biomedical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Reshma Murali, Uddesh Ramesh Wanjari, Anirban Goutam Mukherjee, Abilash Valsala Gopalakrishnan, Sandra Kannampuzha, Arunraj Namachivayam, Harishkumar Madhyastha, Kaviyarasi Renu, Raja Ganesan
Summary: The novel SARS-CoV-2 virus causes COVID-19, a respiratory disorder, and has been found to result in kidney injuries, particularly kidney tubular injuries. Infection with the virus not only leads to new kidney disease, but also increases treatment difficulties and mortality rates in individuals with preexisting kidney diseases. Urinary metabolites from various metabolic pathways can be used to differentiate between COVID-19 patients with and without acute kidney injury (AKI). Metabolomics is expected to play a significant role in predicting outcomes for COVID-19 patients with kidney disease as the understanding of metabolic profiles expands rapidly.
Review
Immunology
Sandra Kannampuzha, Anirban Goutam Mukherjee, Uddesh Ramesh Wanjari, Abilash Valsala Gopalakrishnan, Reshma Murali, Arunraj Namachivayam, Kaviyarasi Renu, Abhijit Dey, Balachandar Vellingiri, Harishkumar Madhyastha, Raja Ganesan
Summary: Lung cancer is a major cause of cancer-related deaths. The altered metabolism of cancer cells results in changes in metabolite concentrations, which can be used to identify distinct metabolic patterns for cancer detection. Understanding and analyzing the variations in metabolites can provide early biomarkers and insights into the progression and type of lung cancer.
Review
Microbiology
Sandra Kannampuzha, Abilash Valsala Gopalakrishnan, Hafiza Padinharayil, Reema Rose Alappat, Kavya V. V. Anilkumar, Alex George, Abhijit Dey, Balachandar Vellingiri, Harishkumar Madhyastha, Raja Ganesan, Thiyagarajan Ramesh, Rama Jayaraj, D. S. Prabakaran
Summary: Infection with viruses, bacteria, and parasites is responsible for about 8-17% of global cancer burden, with one in every five malignancies being caused by an infectious pathogen. Eleven major pathogens are believed to aid in oncogenesis. It is important to identify potential human carcinogens and understand the pathways they induce to effectively prevent and control pathogen-driven cancers. This review focuses on major onco-pathogens, the types of cancer they cause, and the altered pathways leading to cancer progression.
Review
Multidisciplinary Sciences
Shilpa S. Shetty, D. Deepthi, S. Harshitha, Shipra Sonkusare, Prashanth B. Naik, N. Suchetha Kumari, Harishkumar Madhyastha
Summary: Environmental contaminants have significant impacts on human health, but the relationship between pollutants and health effects needs further exploration, especially in less developed countries with poor waste management. Different pollutants contribute to both chronic and acute disorders.
Article
Engineering, Environmental
R. Ranjitha, V. G. Dileep Kumar, Meghana K. Navada, Shivaprasad M. Shetty, B. K. Jayanna, Aarti S. Bhatt, M. S. Santosh, H. Madhyastha, K. Sakai, C. R. Ravikumar
Summary: Metal oxides are highly versatile and practical solutions in modern technology, and it is important to evaluate their cytotoxicity due to environmental concerns. This study focuses on the photocatalytic and cyto-compatibility behavior of Li-doped Co3O4 nanomaterial. The addition of Li to the Co3O4 nanostructure enhances its photodegradation efficiency under UV light, and the Li-doped Co3O4 photocatalyst shows excellent performance in removing hazardous pollutants under visible light. Additionally, the doped nanostructures exhibit lower toxicity and promote cell proliferation. These findings suggest that Li-doped Co3O4 nanostructures have great potential for water remediation and effluent treatment systems.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
