Journal
JOURNAL OF NATURAL MEDICINES
Volume 68, Issue 3, Pages 521-529Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s11418-014-0829-9
Keywords
Chinese bayberry flavonoid extract; Alcohol-induced liver injury; Oxidative stress; Hepatoprotective effects
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Funding
- Zhejiang Provincial Natural Science Foundation of China [Y3110213]
- planning subject of 'the twelfth five-year-plan' in National Science and Technology for the Rural Development in China [2011BAD23B02]
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To evaluate the beneficial effects of Chinese bayberry (Myrica rubra Sieb. et Zucc.) flavonoid extract (CBFE) on chronic alcohol-induced liver oxidative injury in mice, experimental mice were pretreated with different doses of CBFE (50-200 mg/kg) for 4 weeks by gavage feeding. Biochemical markers and enzymatic antioxidants from serum, liver tissue, mitochondria and microsomes were examined. Our results showed that the activities of TC, TG, L-DLC in serum, the activity of CYP2E1 in microsomes, and the levels of MDA in liver tissue and mitochondria, decreased significantly (P < 0.05) in the CBFE-treated group compared with the alcohol group. On the contrary, the activities of ALT, AST, and H-DLC in serum, enzymatic antioxidants GSH-Px, SOD and GST in liver tissue and mitochondria, and HO-1 in microsomes rose markedly (P < 0.05). Histopathological examination revealed that CBFE (200 mg/kg) pretreatment noticeably prevented alcohol-induced hepatocyte apoptosis and fatty degeneration. It was suggested that the hepatoprotective effects exhibited by CBFE on alcohol-induced liver oxidative injury may be due to its potent antioxidant properties.
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