Article
Multidisciplinary Sciences
Nabeela Zahid, Sabaz Ali Khan, Fahad M. Al-Hamaid, Mohammad Maroof Shah, Dunia A. Al Farraj, Mohamed S. Elshikh, Rafiq Ahmad, Mai Ahmad Alghmdi, Arshad Mehmood Abbasi
Summary: This study evaluated the in vitro and in silico inhibitory potential of leaf extracts of Pinus roxburghii and Cedrus deodara against human pathogenic bacteria. Both plant extracts exhibited greater antibacterial activities against Staphylococcus aureus compared to Salmonella typhi and Pseudomonas aeruginosa. Molecular docking analysis showed strong interactions between certain bioactive compounds and bacterial proteins. The antibacterial efficiencies of P. roxburghii and C. deodara suggest their potential application as therapeutic agents against diseases caused by these bacterial strains.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Forestry
Kamal Raj Aryal, Tolak Raj Chapagain, Rajendra Kumar Basukala, Sabitra Khadka, Gopiram Chaudhary, Ram Krishna Budha, Hari Adhikari, Dinesh Jung Khatri, Upendra Aryal, Ram P. Sharma
Summary: Effective forest management relies on accurate information, such as tree volume predictions provided by tree volume models. In this study, we developed tree volume models for Pinus roxberghii and Cedrus deodara in Nepal, using data from a wide range of individuals. The models showed high accuracy and can be applied for various purposes including carbon accounting and forest growth modeling.
FOREST ECOLOGY AND MANAGEMENT
(2023)
Article
Multidisciplinary Sciences
Chao Chen, Xiaoxin Zhang, Hao Huang, Hongyi Bao, Xiaodong Li, Ye Cheng, Jing Zhang, Yin Ding, Yanguang Yang, Haiying Gu, Donglin Xia
Summary: The study showed that poly(lactic-co-glycolic acid) meso-particles containing superoxide dismutase and catalase were effective in attenuating lead-induced cognitive impairment by inhibiting oxidative stress. The bi-enzymes platform displayed a remarkable protective mechanism in preventing memory impairment and reversing lead-induced cognitive impairments.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Neurosciences
Lisa Wintzell, Samuel Klemetz, Stefan Lange, Eric Hanse, Caroline Wass, Joakim Strandberg
Summary: The endogenous peptide antisecretory factor (AF) enhances long-term potentiation (LTP) and spatial learning and memory by disinhibiting GABAergic transmission in the rat hippocampus.
Article
Behavioral Sciences
Amanda Dyer, Maxine De Butte
Summary: This study aimed to examine the effects of chronic low-dose vanadium administration on the behavior of young male rats. The findings suggest that vanadium does not significantly affect exploration, locomotion, or anxiety-like behavior in rats, but does affect novel object recognition performance. Additionally, vanadium administration led to lower latency times in the Morris Water maze task.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Takujiro Homma, Hiroki Fujiwara, Tsukasa Osaki, Satoshi Fujii, Junichi Fujii
Summary: This study investigated the learning and memory abilities of Prdx4 knockout mice and found that Prdx4-KO mice performed poorly in spatial memory tasks. In contrast, their locomotor activity was significantly increased. Molecular analysis revealed increased expression of genes related to ER-associated degradation mechanisms and aberrant expression of proteins associated with calcium homeostasis and synaptogenesis in the brains of Prdx4-KO mice.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Vicko Suswidiantoro, Nuriza Ulul Azmi, Donny Lukmanto, Fadlina Chany Saputri, Abdul Mun'im, Ahmad Aulia Jusuf
Summary: Extracts of turmeric rhizome and bitter melon fruit exhibit antioxidant activity and can provide neuroprotective effects against aspartame-induced memory impairment.
Article
Agriculture, Multidisciplinary
Nan Zhang, Pu Jing
Summary: Research suggests that red cabbage anthocyanins may have health benefits associated with antiaging. In a study on aging mice, it was found that extracts rich in red cabbage anthocyanins and cyanidin-3-diglucoside-5-glucoside significantly reduced cognitive impairment and had no effect on motor disorder. These extracts also increased antioxidant activity and reduced neuronal damage and neuroinflammation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Behavioral Sciences
Ewa Zwierzynska, Boguslawa Pietrzak
Summary: Lacosamide does not impair memory and learning processes, with temporary disruption of emotional memory observed only after a single high dose administration.
EPILEPSY & BEHAVIOR
(2021)
Article
Food Science & Technology
Long Sun, Xian Li, Chenjing Ma, Zhao He, Xin Zhang, Chengye Wang, Min Zhao, Jin Gan, Ying Feng
Summary: The study found that Policosanol (PC) from Ericerus pela wax can enhance learning and memory in mice by promoting the cholinergic system and attenuating oxidative stress.
Article
Medicine, Research & Experimental
Fateme Khodabande, Esmaeil Akbari, Motahareh Rouhi Ardeshiri
Summary: The orexin 1 receptors in the dorsal raphe nucleus play a significant role in the consolidation of spatial reference memory in rats, while the orexin 2 receptors do not have an effect.
Article
Multidisciplinary Sciences
Bataa M. A. El-Kafoury, Enas A. Abdel-Hady, Wesam El Bakly, Wael M. Elayat, Ghada Galal Hamam, Samar M. M. Abd El Rahman, Noha N. Lasheen
Summary: The utilization of digital technology has led to an increase in cell phone use, resulting in electromagnetic radiation that has adverse effects on the brain, making it a new source of pollution. This study investigated the effects of lipoic acid on cognitive functions and hippocampal structure in rats exposed to electromagnetic fields emitted from multiple cell phones. The results showed that EMF exposure enhanced learning ability but interfered with long-term memory consolidation, and lipoic acid treatment improved both learning and memory.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Keyvan Mehri, Zohreh Zavvari Oskuye, Ehsan Nassireslami, Esmail Karami, Mohammad Reza Parvizi
Summary: This study investigated the effects of Botulinum toxin on spatial memory and biochemical and histological parameters in the hippocampus of male rats. Results showed that Botox significantly impaired memory performance and led to a decrease in acetylcholine levels, increase in acetylcholinesterase activity, and morphological damage in the hippocampus. Administration of Rivastigmine partially alleviated these effects and could serve as a protective approach.
Article
Neurosciences
Jemi Feiona Vergil Andrews, Divya Bharathi Selvaraj, Akshay Kumar, Syed Aasish Roshan, Muthuswamy Anusuyadevi, Mahesh Kandasamy
Summary: This study investigated the effect of aspirin on spatial memory in ageing experimental mice. Aspirin was found to enhance working memory, increase the number of new neurons in the hippocampus, reduce the number of microglial cells, and decrease the activity of AChE in the blood.
Review
Behavioral Sciences
Lucia Amendola, Daniel Weary, Gosia Zobel
Summary: Individual variation in responses to anxiety and spatial memory tests is often reported. These variations are related to consistent individual differences in behavior (personality). However, personality differences are rarely considered in anxiety treatment studies. This article focuses on rat literature to describe principles in anxiety and spatial memory tests and discusses the influence of personality and housing conditions on behavioral responses. The authors propose that environmental enrichment can enhance stress resiliency in environmentally sensitive individuals. Incorporating personality measures into study design and analysis can improve research reproducibility.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Chemistry, Applied
Meron Hiruy, Daniel Bisrat, Avijit Mazumder, Kaleab Asres
Summary: Aloesin and 7-O-methyl-6'-O-coumaroylaloesin isolated from Aloe monticola Reynolds leaf latex exhibited antimicrobial effects against various bacteria and fungi, particularly effective against certain pathogenic strains. Toxicity tests on mice showed no toxicity up to a certain dose, indicating the potential medicinal value of these compounds from Aloe monticola.
NATURAL PRODUCT RESEARCH
(2021)
Review
Chemistry, Organic
Chanchal Singh, Rajnish Kumar, Avijit Mazumder, Salahuddin, Ajay Kumar, Rakesh Sahu, Shivali Mishra, Mohd Mustqeem Abdullah
Summary: This article presents various synthesis strategies for pharmacologically active compounds containing benzothiazole with different substituents, as well as highlighting their pharmacological actions and molecular interactions with different biological molecules.
MINI-REVIEWS IN ORGANIC CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Rakesh Sahu, Rakhi Mishra, Rajnish Kumar, Salahuddin, Chandana Majee, Avijit Mazumder, Ajay Kumar
Summary: This review discusses the importance of pyridine in the development of anticancer drugs, as well as its molecular docking, structure-activity relationship, market availability, and recent research works. Pyridine derivatives have wide applications in controlling and curing cancer, and researchers are currently focusing on the development of new pyridine-based drugs.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Rajnish Kumar, Chanchal Singh, Avijit Mazumder, Salahuddin, Md Mustaqeem Abdullah, Vivek Kumar, Pavan Prakash Giri
Summary: This article discusses the synthesis of anti-cancer benzimidazoles and their derivatives, their important role in treating complex cancers, and highlights the benzimidazole derivatives under clinical trials.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Review
Plant Sciences
Avijit Mazumder, Bharti Yadav, Harender Sharma
Summary: Peptic ulcers are erosions of the gastrointestinal mucosa that can reach the muscular layer and are a widespread health condition affecting millions of individuals. While gastric acid secretion is just one factor in the pathogenesis of peptic ulcers, flavonoids from herbal plants have shown promising cytoprotective and rehabilitative actions, making them of great interest in biological assays.
PLANT SCIENCE TODAY
(2021)
Review
Chemistry, Medicinal
Himanshu Singh, Rajnish Kumar, Ranjeet Kumar Yadav, Avijit Mazumder, Salahuddin, Bharti Chauhan, Mohd Mustaqeem Abdullah
Summary: Heterocyclic compounds, especially those containing nitrogen and sulfur atoms, play a crucial role in medicinal and organic chemistry. The therapeutic activity of many marketed drugs is attributed to the presence of heterocyclic scaffolds. Benzothiazole, a benzofused heterocyclic compound, is widely found in natural chemicals and is known for its pharmacological potential. This comprehensive review focuses on the synthesis methods, biological activities, structure-activity relationships, and targets of benzothiazole and its derivatives, providing valuable information for future research in medicinal chemistry.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Review
Oncology
Himanshu Singh, Rajnish Kumar, Avijit Mazumder, Ranjeet Kumar Yadav, Bharti Chauhan, Mohd. Mustaqeem Abdulah
Summary: Cancer is a degenerative disease caused by abnormal cell proliferation. Synthetic anticancer drugs have significant adverse effects, prompting researchers to explore natural compounds and their derivatives with less toxicity. This literature review focuses on the anticancer activity of camphor and menthol derivatives, highlighting their potential cytotoxicity against different cancer cell lines. The synthesis methods for these derivatives and their structure-activity studies are also discussed.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Medicinal
Bharti Chauhan, Rajnish Kumar, Avijit Mazumder, Salahuddin Salahuddin, Himanshu Singh, Ranjeet Kumar Yadav, Mohd. Mustaqeem Abdullah
Summary: Epilepsy is a chronic neurological disorder causing periodic and unpredictable seizures, affecting various aspects of patients' well-being. Current antiepileptic drugs are insufficient, highlighting the need for focused research on the synthesis of potential molecules with fewer adverse effects. Benzo-fused five-membered heterocyclic moieties, such as benzothiazole and benzimidazole, have been underutilized as building blocks for anticonvulsant drug synthesis, despite their great potential. This study emphasizes synthetic approaches and structure-activity relationship studies of anticonvulsant benzothiazole and benzimidazole derivatives, providing valuable knowledge for future research in the field of medicinal chemistry.
LETTERS IN DRUG DESIGN & DISCOVERY
(2023)
Review
Chemistry, Organic
Abhishek Shankar Sharma, Salahuddin, Avijit Mazumder, Rajnish Kumar, Vimal Datt, Km Shabana, Sonakshi Tyagi, Mohammad Shahar Yar, Mohamed Jawed Ahsan
Summary: Due to their diverse applications, quinoline and 1,3,4-oxadiazole have become important heterocyclic compounds in industrial and synthetic organic chemistry. They have shown potential in various medical conditions and synthetic protocols have been developed to explore their structure-activity relationship for further research.
CURRENT ORGANIC SYNTHESIS
(2023)
Review
Chemistry, Medicinal
Ranjeet Kumar Yadav, Rajnish Kumar, Himanshu Singh, Avijit Mazumdar, Salahuddin, Bharti Chauhan, Mohd. Mustaqeem Abdullah
Summary: This review article summarizes the synthetic approaches and pharmacological activities of benzothiazole and its derivatives, emphasizing their importance in various pharmacological conditions. The structure-activity relationship is highlighted to provide researchers with insights for future research on benzothiazoles.
MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Anmol Atriya, Chandana Majee, Rupa Mazumder, Alka N. Choudhary, Salahuddin, Avijit Mazumder, Aman Dahiya, Neha Priya
Summary: Terpenoids are naturally occurring secondary metabolites that have diverse pharmacological benefits. However, their limited lipophilicity, dissolution rate, aqueous solubility, and drug permeability hinder their effective use. To overcome this limitation, strategies such as nanotechnology, cocrystal, and glycosylation have been employed. This review summarizes the chemistry of terpenoids, factors limiting their bioavailability, and strategies used to enhance their bioactivity.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2023)
Review
Plant Sciences
Shobhini Chandel, Saumya Das, Avijit Mazumder, Vijayant Singh Chauhan
Summary: The genus Euphorbia, belonging to the family Euphorbiaceae, includes more than 1600 species. Among them, Euphorbia hirta, a type of annual weed, is known as the asthma plant and possesses medicinal properties. It has been listed in the Chinese Pharmacopoeia and African pharmacopoeia for various drugs. E. hirta is found in tropical and temperate regions worldwide, as well as in Africa, Bangladesh, Australia, and India, where it is used as a therapeutic herb. This review focuses on its phytoconstituent profile, therapeutic profile, and other significant biological characteristics, including secondary active compounds such as polyphenols, flavonoids, steroids, tannins, and alkaloids that exhibit antimicrobial, antifertility, antidiabetic, anti-inflammatory, anticancer, antiplasmodial, antitumor properties, and are effective in managing various disorders. Additionally, E. hirta is utilized to treat hematuria, gonorrhea, and asthma prophylaxis in South Africa, as well as an enema remedy in the Gold Coast. Topical use of alcohol-based fruit and leaf extract of E. hirta can treat chronic inflammatory disorders like inflammatory bowel disease, psoriasis, and diabetic-induced sores. This review is valuable for the identification and monograph preparation of E. hirta.
PLANT SCIENCE TODAY
(2023)
Review
Chemistry, Medicinal
Sonakshi Tyagi, Salahuddin, Avijit Mazumder, Rajnish Kumar, Vimal Datt, Km Shabana, Mohammad Shahar Yar, Mohamed Jawed Ahsan
Summary: Quinoline has recently gained importance in industrial and synthetic organic chemistry, due to its widespread applications. Quinoline derivatives have been used in clinical trials for various cancer-related medical conditions. This review focuses on recent progress in the synthesis of novel quinoline derivatives as potential anti-cancer agents, as well as their structure-activity relationship, providing valuable insights for future research and development.
MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Anuradha Singh, Suneela Dhaneshwar, Avijit Mazumder
Summary: The aim of this study was to evaluate the neuroprotective potential of berberine, levetiracetam and their combination in lead acetate-induced neurotoxicity. A drug repositioning approach was used to study the potential therapeutic effect of berberine and levetiracetam in Alzheimer's disease.
CURRENT REVIEWS IN CLINICAL AND EXPERIMENTAL PHARMACOLOGY
(2023)
Article
Chemistry, Organic
Neeru Rani, Salahuddin, Avijit Mazumder, Rajnish Kumar, Rakesh Sahu, Mohamed Jawed Ahsan, Mohammad Sarafroz, Shadab Ahmad Siddiqui, Mohammad Shahar Yar
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY
(2020)
