Journal
JOURNAL OF NATURAL MEDICINES
Volume 67, Issue 2, Pages 369-374Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s11418-012-0672-9
Keywords
Quercetin glucoside; B16 melanoma cells; Tyrosinase; Helminthostachys zeylanica
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Funding
- Grants-in-Aid for Scientific Research [22380094] Funding Source: KAKEN
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Two novel quercetin glucosides, namely 4'-O-beta-d-glucopyranosyl-quercetin-3-O-beta-d-glucopyranosyl-(1 -> 4)-beta-d-glucopyranoside (compound 1) and 4'-O-beta-d-glucopyranosyl-(1 -> 2)-beta-d-glucopyranosyl-quercetin-3-O-beta-d-glucopyranosyl-(1 -> 4)-beta-d-glucopyranoside (compound 2), were isolated from Helminthostachys zeylanica root 50 % EtOH extract. Structural analysis of isolated compounds was achieved mainly by 600 MHz and 800 MHz NMR, UPLC-TOFMS and GC-MS. Of the two quercetin glucosides, compound 1 showed a high melanogenic acceleratory effect, 2.7 times higher than control, at 10 mu M concentration in murine B16 melanoma cells, with no cytotoxic effect.
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