4.4 Article

Promoting the effect of chemical constituents from the flowers of Poacynum hendersonii on adipogenesis in 3T3-L1 cells

Journal

JOURNAL OF NATURAL MEDICINES
Volume 66, Issue 1, Pages 39-48

Publisher

SPRINGER JAPAN KK
DOI: 10.1007/s11418-011-0549-3

Keywords

Poacynum hendersonii; Kaempferol 3-O-sophoroside; Poacynose; Quantitative analysis; Apocynaceae

Funding

  1. MEXT (Ministry of Education, Culture, Sports, Science and Technology)
  2. Grants-in-Aid for Scientific Research [22510240] Funding Source: KAKEN

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A novel sugar ester poacynose (1) was isolated from the flowers of Poacynum hendersonii together with 31 known compounds. The structure of 1 was established mainly on the basis of 1D and 2D NMR spectral data. Among the isolates, several constituents, such as kaempferol 3-O-sophoroside (5), picein (16), and 4-hydroxybenzoic acid 4-O-beta-d-glucopyranoside (17) moderately promoted adipogenesis of 3T3-L1 cells. In addition, simultaneous quantitative analysis of eight flavonoid constituents from the flower and leaf parts of P. hendersonii was developed.

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