Article
Pharmacology & Pharmacy
Zhonghua Guo, Ping Qi, Donghong Pei, Xiuju Zhang
Summary: Osteoporosis is a common metabolic disorder and a major public health challenge. This study successfully developed Raloxifene HCl-loaded solid lipid nanoparticles decorated gel, which showed improved drug permeation and bioavailability, effectively treating osteoporosis.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Heba F. Salem, Amr Gamal, Haitham Saeed, Alaa S. Tulbah
Summary: The study found that by optimizing the formulation and using liposomal gel as a carrier, Raloxifene could exhibit higher bioavailability and anti-tumor action in the treatment of breast cancer.
Review
Pharmacology & Pharmacy
Mushfiq Akanda, Sadeque Hossain Mithu, Dennis Douroumis
Summary: Solid lipid nanoparticles (SLN) are at the forefront of nanotechnology, with potential applications in drug delivery and research. They offer controlled and site-specific drug delivery, making them a popular choice over other colloidal carriers. This review discusses the production techniques, drug incorporation, and release mechanisms of SLN. The route of administration and in vivo fate of SLNs are also explored, along with their potential in anti-cancer drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wei Xu, Zhaoyou Deng, Yifei Xiang, Dujuan Zhu, Dandan Yi, Yihao Mo, Yu Liu, Lanqian Qin, Ling Huang, Bingjie Wan, Liqin Wu, Xin Feng, Jiakang He
Summary: In this study, a tolfenamic acid solid lipid nanoparticle (TA-SLN) suspension was prepared to improve the sustained release and bioavailability of nonsteroidal anti-inflammatory drugs. The TA-SLN suspension showed improved sustained drug release in vitro and increased pharmacokinetic parameters in pigs compared with TA injection, indicating its potential as a promising new formulation.
Article
Pharmacology & Pharmacy
Xinhui Du, Na Gao, Xiaoyong Song
Summary: RLX is a second-generation selective estrogen receptor modulator used to treat osteoporosis in postmenopausal women. However, its poor solubility has hindered the development of injectable forms and led to low oral bioavailability. This study introduced a bioadhesive nanosystem for oral delivery of RLX, enhancing its bioavailability and addressing formulation challenges.
Article
Pharmacology & Pharmacy
Antonella Obinu, Giovanni Pietro Burrai, Roberta Cavalli, Grazia Galleri, Rossana Migheli, Elisabetta Antuofermo, Giovanna Rassu, Elisabetta Gavini, Paolo Giunchedi
Summary: In this study, solid lipid nanoparticles (SLN) loaded with GEN were developed to improve its oral bioavailability by avoiding first-pass metabolism through intestinal lymphatic absorption. The SLN obtained by hot homogenization showed high stability and drug loading capacity.
Review
Chemistry, Medicinal
Viliana Gugleva, Velichka Andonova
Summary: The challenge faced by researchers in achieving sufficient ocular bioavailability is due to the complex structure of the eye and its protective physiological mechanisms. Low viscosity eye drops and short ocular residence time contribute to low drug concentration at the target site. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are being developed as drug delivery platforms to overcome these challenges and enhance ocular bioavailability. They are biocompatible, biodegradable, and can be sterilized and scaled-up. Surface modifications can prolong ocular residence time, enhance penetration, and improve performance.
Article
Pharmacology & Pharmacy
Basalat Imran, Fakhar Ud Din, Zakir Ali, Anam Fatima, Muhammad Waseem Khan, Dong Wuk Kim, Maimoona Malik, Saba Sohail, Sibgha Batool, Muhammad Jawad, Kanwal Shabbir, Alam Zeb, Barkat Ali Khan
Summary: In this study, dexibuprofen solid lipid nanoparticles (DBPN-SLNs) were successfully prepared and optimized. The optimized formulation exhibited desirable morphological characteristics and stability, and significantly delayed the drug release, resulting in enhanced oral bioavailability.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Azadeh Emami, Hossein Ghafouri, Reyhaneh Sariri
Summary: This study developed and optimized a PD-loaded SLN formulation and evaluated its efficacy in breast cancer cell lines. Apoptosis was confirmed as the mechanism of cell death, and the PD-loaded SLN showed significant increase in apoptosis. In vivo studies on mice also supported this effect. PD-loaded SLN may be a promising breast cancer treatment without recognizable side effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Shabnam Dolatabadi, Maryam Karimi, Samira Nasirizadeh, Mahdi Hatamipour, Shiva Golmohammadzadeh, Mahmoud Reza Jaafari
Summary: Curcuminoids-loaded solid lipid nanoparticles and nano structured lipid carriers demonstrated significant improvement in pharmacokinetic parameters, suggesting that these new formulations can enhance the bioavailability and absorption of curcuminoids.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Iqra Rahat, Md. Rizwanullah, Sadaf Jamal Gilani, May Nasser Bin-Jummah, Syed Sarim Imam, Chandra Kala, Mohammad Asif, Sultan Alshehri, Satish K. Sharma
Summary: Chitosan modified solid lipid nanoparticles were developed to enhance the oral bioavailability of thymoquinone, showing optimized nanoparticles with good in vitro and ex vivo performance, strong mucoadhesive properties, and controlled drug release. The results indicated significantly improved oral bioavailability compared to thymoquinone suspension.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Monica Cerqueira, Efres Belmonte-Reche, Juan Gallo, Fatima Baltazar, Manuel Banobre-Lopez
Summary: Cancer is a leading cause of death worldwide, with a projected increase in global cancer incidence in the next two decades. Nanomedicine formulations have the potential to improve the effectiveness of conventional cancer therapies. However, the targeting efficiency of advanced nanomedicines in oncology is currently one of the major limitations, highlighting the need for more efficient nanoformulation designs.
Article
Chemistry, Medicinal
Ibrahim A. Aljuffali, Md. Khalid Anwer, Mohammed Muqtader Ahmed, Ahmed Alalaiwe, Mohammed F. Aldawsari, Farhat Fatima, Shahid Jamil
Summary: In this study, the toxic effects of gefitinib-loaded solid lipid nanoparticles on human breast cancer cells were investigated. The optimized formulation showed sustained drug release and enhanced activity against the cancer cells, suggesting it as a promising therapeutic alternative for breast cancer.
Article
Multidisciplinary Sciences
Nishtha Chaurawal, Charu Misra, Harshita Abul Barkat, Reena Jatyan, Deepak Chitkara, Md Abul Barkat, Teenu Sharma, Bhupinder Singh, Kaisar Raza
Summary: This study encapsulated sorafenib tosylate (SFB) into a biocompatible carrier, improving its bioavailability by using a microemulsion formulation. The results showed that the sorafenib-loaded microemulsion had a stronger inhibitory effect on tumor cells compared to the original SFB, and the drug release was controlled.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Zhonghua Guo, Rabia Afza, Muhammad Moneeb Khan, Saif Ullah Khan, Muhammad Waseem Khan, Zakir Ali, Sibgha Batool, Fakhar ud Din
Summary: In this study, Raloxifene-loaded polymeric nanoparticles (RLX-PNPs) were developed and investigated for the treatment of osteoporosis. The RLX-PNPs showed good particle properties and sustained release behavior, leading to improved bioavailability of the drug. The findings suggest that RLX-PNPs have the potential to be an effective treatment for osteoporosis.
