Article
Polymer Science
Amaraporn Wongrakpanich, Nichakan Khunkitchai, Yanisa Achayawat, Jiraphong Suksiriworapong
Summary: This study developed ketorolac microparticles using hyaluronic acid stabilized poly(lactide-co-glycolide) (PLGA), poly(lactide) (PLA), and their blend for osteoarthritis treatment. Different emulsification techniques and polymer compositions influenced the microparticle characteristics, with probe sonication resulting in smaller size and broader size distribution than high-speed stirring. The microparticles showed biphasic drug release over 35 days and demonstrated potential for treating osteoarthritis.
Article
Biotechnology & Applied Microbiology
Shenghui Su, Qiangqiang Tang, Dongbin Qu
Summary: A composite coating consisting of CaHPO4 conversion coating and polylactic acid (PLA) was constructed on pure zinc. The presence of the coating reduced the pH value and enhanced corrosion resistance, while also improving the cytocompatibility of pure zinc.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Edisson-Mauricio Pacheco-Quito, Luis -Miguel Bedoya, Juan Rubio, Aitana Tamayo, Roberto Ruiz-Caro, Maria-Dolores Veiga
Summary: Layer-by-Layer vaginal films were developed for the controlled release of acyclovir to reduce the prevalence of genital herpes and prolong mucoadhesion residence time.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Mohamed Mahameed, Shuai Xue, Bozhidar-Adrian Stefanov, Ghislaine Charpin-El Hamri, Martin Fussenegger
Summary: In this study, a rapamycin-actuated protein-induction device (RAPID) based on split sec-TEVp was engineered to achieve rapid insulin release. This technology may serve as a foundation for cell-based therapies requiring instantaneous biopharmaceutical availability.
Article
Biochemistry & Molecular Biology
Tovi Shapira-Furman, Abraham J. Domb
Summary: This report introduces a novel approach of nano formulation using stereo-interaction mechanism with poly(D-lactide)-polyethylene glycol (D-PLA-PEG) to address the challenges of controlled drug delivery for peptide and protein therapeutics. The study demonstrates that nano particles formed by the interaction between water-soluble D-PLA-PEG and insulin can achieve sustained release of insulin, showing potential application in diabetes treatment.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Engineering, Chemical
Attaf Djoullah, Remi Saurel
Summary: Riboflavin encapsulated in pea protein microparticles crosslinked by transglutaminase displayed controlled release properties in simulated gastrointestinal conditions. The microparticles showed potential for delivering riboflavin up to the intestinal digestion phase, with release mechanisms governed by diffusion and support degradation phenomenon under different conditions.
JOURNAL OF FOOD ENGINEERING
(2021)
Article
Polymer Science
Myrla Melo, Andre Da Silva, Edson Silva Filho, Ronaldo Oliveira, Jarbas Silva Junior, Juliana Paula Oliveira, Antonio Vaz, Jose Moura, Jose Pereira Filho, Leilson Bezerra
Summary: Microencapsulated urea formulations with different urea concentrations were used in ruminant feeding to control the release rate of ammonia in the rumen, improving nitrogen utilization and reducing the risk of ruminant intoxication. The degradation kinetics demonstrated that controlled release from microencapsulated systems significantly decreased the release rate compared to free urea. Additionally, blood serum concentrations of certain metabolites were higher in sheep receiving microencapsulated urea, with the MPec2 system being recommended for its more controlled core release.
Article
Biochemistry & Molecular Biology
Jinglei Li, Haishan Wu, Kexin Jiang, Yuting Liu, Liu Yang, Hyun Jin Park
Summary: An effective delivery system for oral insulin administration was developed using alginate microbeads containing chitosan nanoparticles (CNP) for controlled release of insulin. The optimized CNP with a size around 150 nm and encapsulation efficiency of 23.70% showed promising potential for oral insulin delivery. The insulin-loaded alginate microbeads significantly lowered blood glucose level in hyperglycemia model mice in a controlled manner for up to 96 hours, demonstrating the potential for extended release of insulin.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Simon Faba, Marina P. Arrieta, Julio Romero, Angel Aguero, Alejandra Torres, Sara Martinez, Emilio Rayon, Maria Jose Galotto
Summary: This study aimed to develop PLA bionanocomposite foams loaded with carvacrol cocrystal by supercritical CO2 for controlled release in food packaging. The results showed that the addition of nanoclay improved the mechanical properties of the composite, and a higher content of C30B increased the incorporation of carvacrol. The prepared nanocomposite foam exhibited lower diffusion coefficient and antioxidant activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Chemistry, Applied
Zhengang Xie, Wenlong Liang, Qiuyu Xiong, Yanyan Zhao, Jingli Cheng, Xianbin Li, Jinhao Zhao
Summary: In this study, pH-sensitive acetalated dextran microparticles were prepared to encapsulate and control the release of the pesticide pyraclostrobin. The results showed that these microparticles exhibited comparable fungicidal ability and better control efficacy against the target pathogen compared to the pesticide in its original form. Additionally, the microparticles extended the half-life of pyraclostrobin in water and reduced its acute toxicity to zebrafish.
CARBOHYDRATE POLYMERS
(2022)
Article
Food Science & Technology
Jing Xu, Lixin Lu, Haoyue Ning, Yuemei Zhang, Liao Pan
Summary: The synthesis of green UV-controlled release active packaging films using 4-hydroxy-7-methoxycoumarin as a photosensitizing factor, beta-cyclodextrin as the main molecule, and PLA-PVA as the film-making base solution was reported. The study found that UV light can be used to control the release of p-methoxybenzaldehyde and regulate the release from inclusion complex and film.
FOOD PACKAGING AND SHELF LIFE
(2023)
Article
Agriculture, Multidisciplinary
Shanshan Tie, Wentao Su, Xuedi Zhang, Yannan Chen, Xue Zhao, Mingqian Tan
Summary: This study successfully constructed a delivery system using a microfluidic chip to protect procyanidins and achieve their pH-controlled release in simulated gastrointestinal fluid. The system showed improved stability and potential applications in delivering other nutrients.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Zhixiang Cui, Chang Liu, Shuman Cui, Lu Qin, Xin Zhang, Jian Guan, Shirui Mao
Summary: Polyelectrolyte nanocomplex (PEC) embedded microparticles using CS/PVA as the composite matrix were fabricated for enhanced oral insulin delivery. Optimal properties were achieved with CS 50 kDa in the matrix, showing good stability, improved enzymatic stability, and enhanced mucus penetration. The CS/PVA 1:1 group exhibited the highest relative pharmacological availability of 6.80%.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Zhuo Li, Dehai Yu
Summary: This study demonstrates the development of a highly stable, pH-responsive fish oil-in-water Pickering emulsion stabilized by ChNF/CNF complexes. The emulsion exhibits a remarkable release of approximately 95% of the embedded ibuprofen within the pH range of 5-9, and the drug loading and encapsulation efficiency reach their peak at a 1% ibuprofen dosage with values of 1% and 87%, respectively. This research highlights the potential of using ChNF/CNF complexes in designing versatile, stable, and entirely renewable Pickering systems for controlled drug delivery, with potential applications in food and eco-friendly products.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Hao-Ying Li, En-Yu Xu
Summary: The challenges of current spray-dried microparticles for inhalation are improving aerosolization performance and creating sustained drug release. In this study, pullulan was used as an excipient to prepare inhalable microparticles, and different additives were used for modification. The pullulan-based microparticles showed improved flowability, enhanced aerosolization behavior, and a higher fine particle fraction compared to lactose-based microparticles. The modified microparticles also exhibited increased emitted fractions and fine particle doses, suggesting improved deep lung drug deposition. Additionally, pullulan-based microparticles demonstrated sustained drug release profiles with longer release time.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Polymer Science
Kentaro Yoshida, Akane Yamaguchi, Hiroki Midorikawa, Toshio Kamijo, Tetsuya Ono, Takenori Dairaku, Takaya Sato, Tsutomu Fujimura, Yoshitomo Kashiwagi, Katsuhiko Sato
Article
Chemistry, Analytical
Zhenyong Lu, Yue Wang, Yasushi Hasebe, Zhiqiang Zhang
Summary: A simple and highly selective electrochemical sensor based on carbonized lotus stem was developed for the simultaneous determination of hydroquinone, catechol, and nitrite. The sensor showed well-separated oxidation peaks for the analytes, improved their simultaneous determination. The results suggest that natural biomass can be used to design porous carbon for electrochemical sensors.
Article
Chemistry, Multidisciplinary
Yan Zhang, Yue Wang, Zhiqiang Zhang, Ahmed Sobhy, Susumu Sato, Masaya Uchida, Yasushi Hasebe
Summary: Developed a high-performance tyrosinase biosensor for sensitive detection of catechol by coadsorbing tyrosinase and acridine orange on natural mineral, with acridine orange playing important roles in enhancing enzyme adsorption, providing efficient orientation support, and stabilizing enzyme in suitable microenvironment on the surface.
Article
Chemistry, Analytical
Yue Wang, Jinping Wu, Tian Yang, Zhong Wang, Yasushi Hasebe, Tianhang Lv, Zhiqiang Zhang
Summary: This study explored an ascorbic acid electrochemical sensor fabricated using ferrocene methanol modified multi-walled carbon nanotube yarn, showing exceptional performance and potential for diverse applications. Factors influencing sensor performance were investigated, highlighting its broad potential in flexible, implantable, and wearable electrochemical sensors.
Article
Chemistry, Analytical
Jifan Zhao, Yue Wang, Ting Wang, Yasushi Hasebe, Zhiqiang Zhang
Summary: A conductive molten salt composite PR/Ag was synthesized and used as an electrocatalyst for detecting hydrogen peroxide. It showed higher conductivity and sensitivity than natural PR, with good selectivity to H2O2 and resistance to interference from other compounds. This method is considered a sensitive, selective, and reliable tool for highly detecting H2O2.
ANALYTICAL SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Zhenyong Lu, Yue Wang, Yaming Zhu, Yasushi Hasebe, Zhiqiang Zhang
Summary: In this study, popcorn-derived microporous carbon was successfully prepared and used as an electrochemical sensor material for simultaneous detection of HQ, CC and NT. The prepared material exhibited high electrocatalytic activity and achieved well-separated peaks under optimized conditions. It showed a wide linear range and low detection limits, making it suitable for fabricating selective and sensitive electrochemical sensors.
Article
Chemistry, Multidisciplinary
Kanako Nozawa-Kumada, So Onuma, Kanako Ono, Tomohiro Kumagai, Yuki Iwakawa, Katsuhiko Sato, Masanori Shigeno, Yoshinori Kondo
Summary: A transition-metal-free intermolecular coupling reaction of halocompounds with styrenes was developed using NaH and 1,10-phenanthroline as catalysts. The reaction exhibited complete anti-Markovnikov selectivity and could tolerate a wide range of halocompounds, including aryl and alkyl halides. Mechanistic studies revealed that an anilide anion generated in situ by the NaH-mediated reduction of 1,10-phenanthroline acted as an electron donor and a hydrogen source.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Polymer Science
Kentaro Yoshida, Toshio Kamijo, Tetsuya Ono, Takenori Dairaku, Shigehiro Takahashi, Yoshitomo Kashiwagi, Katsuhiko Sato
Summary: LbL films prepared by combining various polycationics and TEMPO-PAA were found to decompose under electrical potential. The decomposition rate varied depending on the type and amount of polycationics used.
Article
Chemistry, Multidisciplinary
Yan Zhang, Yue Wang, Yan Dong, Zhiqiang Zhang, Yasushi Hasebe, Jianmin Zhu, Zhaobin Liu, Enjun Gao
Summary: A highly sensitive and selective electrochemical biosensor for catechol detection was developed by immobilizing tyrosinase on a glassy carbon electrode modified with sulfide minerals in the co-adsorption of acridine orange. This new sensor showed excellent electrochemical activity and good reproducibility, stability, repeatability, and anti-interference ability.
Article
Chemistry, Multidisciplinary
Yue Wang, Shiori Aoki, Kazuyuki Nara, Yugo Kikuchi, Zeting Jiao, Yasushi Hasebe
Summary: Methylene blue (MB) acts as a stabilizer for preventing denaturation of adsorbed tyrosinase (TYR) on a carbon felt (CF) surface. MB serves as an effective adhesive for TYR immobilization on CF. The coadsorbed TYR and MB on CF work as an excellent working electrode unit for sensitive detection in an electrochemical biosensor.
Article
Chemistry, Multidisciplinary
Tingting Ma, Yue Wang, Yasushi Hasebe, Zhiqiang Zhang
Summary: A simple, rapid, cost-effective and non-enzymatic amperometric sensor based on CB-MLN modified GCE was developed for sensitive and simultaneous determination of UA, DA, and AA. The synergistic effect of CB and MLN enhanced the electrochemical catalytic reaction and oxidation currents of UA, DA, and AA. The sensor demonstrated excellent performance in the electrochemical oxidation of AA, DA, and UA with well-separated oxidation potentials and low detection limits.
Article
Chemistry, Analytical
Fumiya Sato, Haruka Nakano, Toshio Kamijo, Kazuhiro Watanabe, Tsutomu Fujimura, Yasufumi Takahashi, Katsuhiko Sato
Summary: Nanopore sensing was used to measure the changes in charge and physical state around the nanopores. The study focused on vancomycin sensing using nanopores modified via Au-S bonds with DTBA-PBA. The method demonstrated the potential for quick and easy in situ quantification of not only vancomycin but also other pharmaceuticals with serious side effects.
Article
Electrochemistry
Kota Honda, Kentaro Yoshida, Katsuhiko Sato, Hiroki Ida, Yasufumi Takahashi
Summary: The layer-by-layer technique is a simple method for fabricating multi-layered thin films by alternatingly adsorbing anionic and cationic polyelectrolytes through electrostatic interactions. In this study, the in situ characterization of thin films with different layer numbers was performed using SICM, and the effects of fabrication conditions on film thickness and surface morphology were investigated.
ELECTROCHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Tingting Ma, Yue Wang, Ying Hou, Enlei Wang, Guoqing Yin, Yasushi Hasebe, Zhiqiang Zhang
Summary: In this study, a glucose biosensor based on pyrite, chitosan, and glucose oxidase was successfully fabricated through electrostatic force. The step-by-step assembly of these components on a glassy carbon electrode resulted in a biosensor with strong adhesion and good bioelectrocatalytic activity. The biosensor showed a linear range of 0.5 to 60 mM for glucose detection.
ANALYTICAL SCIENCES
(2022)
Article
Chemistry, Analytical
Yoshitomo Kashiwagi, Tetsuya Ono, Fumiya Sato, Masayuki Kumano, Kentaro Yoshida, Takenori Dairaku, Yusuke Sasano, Yoshiharu Iwabuchi, Katsuhiko Sato
SENSING AND BIO-SENSING RESEARCH
(2020)