Article
Biochemistry & Molecular Biology
Madhuranthakam Reddi Nagesh, Natesan Vijayakumar, Ramaswamy Anandan, Mani Renuka, Venkatesan Amalan, R. Kavitha, Samuel Raj Babu Arulmani, Mohammad Z. Ahmed, Ali S. Alqahtani, Fahd A. Nasr, Abdulaziz M. Alqahtani, Omar M. Noman, Abdullah A. Al-Mishari
Summary: In this study, the cytotoxicity and genotoxicity properties of silver nanoparticles (Ag-NPs) made from a crude ethanolic extract of Salacia chinensis were evaluated using in vitro and in vivo methods. The results showed that the test Ag-NPs did not exhibit cytotoxicity on fibroblast cell line and genotoxic activity on CHO cell line. The in vivo study in Swiss albino mice further confirmed the lack of genotoxicity of the Ag-NPs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Ana B. V. Teixeira, Natalia C. S. Moreira, Catarina S. Takahashi, Marco A. Schiavon, Oswaldo L. Alves, Andrea C. Reis
Summary: The commercial endodontic sealers AH Plus showed cytotoxic effects on HGF cells when incorporated with nanostructured silver vanadate, while Sealer 26 and Endomethasone N released more V4+/V5+ ions over 7 days. The 10% concentration of AH Plus induced apoptosis in HGF cells after 7 days.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Una Stamenovic, Sladana Davidovic, Sandra Petrovic, Andreja Leskovac, Milovan Stoiljkovic, Vesna Vodnik
Summary: Two Ag-PANI/PVP nanocomposites with similar silver content but different morphologies were prepared by integrating silver nanoparticles during oxidative polymerization. These nanocomposites showed strong antimicrobial potential against indicator microbial strains, making them suitable for non-medical applications like wastewater treatment.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
B. Marciniak, R. Kontek, J. Zuchowski, A. Stochmal
Summary: Low-polarity fractions from sea-buckthorn exhibit strong cytotoxicity against cancer cells, potentially eliminating them through promoting apoptosis and moderate genotoxicity. Triterpenoids play a key role in this process.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Abdelaziz Saafane, Isabelle Durocher, Marion Vanharen, Denis Girard
Summary: Silver nanoparticles (AgNPs) have potential effects on the biology of neutrophils, inducing rapid apoptosis and activating actin polymerization through the MAPK pathway. These nanoparticles can also transiently attract neutrophils in vivo.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Physical
Eduardo Padilla-Camberos, Karen J. Juarez-Navarro, Ivan Moises Sanchez-Hernandez, Omar Ricardo Torres-Gonzalez, Jose Miguel Flores-Fernandez
Summary: This study evaluated the toxicological effects of silver nanoparticles synthesized with plants. The results showed that these nanoparticles did not exhibit adverse effects at the tested concentrations, but little is known about their potential long-term effects on physiological systems.
Article
Biochemistry & Molecular Biology
Elcin Bakir, Tugbagul Cal, Sevtap Aydin Dilsiz, Hande Canpinar, Ayse Eken, Ulku Undeger Bucurgat
Summary: The study found that flurbiprofen has cytotoxic, genotoxic, and apoptotic effects in human cancer cells, potentially inducing apoptosis at the gene level.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Toxicology
Juelide Secerli, Seyma Adatepe, Sevde Altuntas, Gizem Rueya Topal, Onur Erdem, Merve Bacanli
Summary: This study aimed to evaluate the antioxidant properties of naringin, berberine, and poly(methylmethacrylate) (PMMA) nanoparticles encapsulated with naringin or berberine, as well as their effects on cell cytotoxicity, genotoxicity, and apoptosis. The results showed that as the concentration increased, the antioxidant activity of naringin, berberine, and the encapsulated PMMA nanoparticles also increased significantly. All compounds tested exhibited cytotoxic effects after exposure for 24, 48, and 72 hours in both cell lines. However, genotoxic effects were not observed at lower concentrations. Further in vivo and in vitro research is needed to explore the potential of polymeric nanoparticles encapsulated with naringin or berberine for cancer treatment.
TOXICOLOGY IN VITRO
(2023)
Article
Chemistry, Physical
Sekar Vijayakumar, Jingdi Chen, M. Amarnath, Kanchanlata Tungare, Mustansir Bhori, Mani Divya, Zaira Gonzalez-Sanchez, Esteban F. Duran-Lara, Baskaralingam Vaseeharan
Summary: In this study, silver nanoparticles (Ag NPs) were synthesized using a green method and their cytotoxicity, phytotoxicity, and photocatalytic activity were evaluated. The green synthesized Ce-Ag NPs showed dose-dependent cytotoxicity against human normal keratinocyte and breast cancer cells. Additionally, Ce-Ag NPs had minimal impact on seed germination and plant growth of Mung beans, but affected Wheat seed germination and shoot length.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Biotechnology & Applied Microbiology
Asmaa Elnady, Noha M. Sorour, Rateb N. Abbas
Summary: Multi-drug resistant bacteria pose a serious global problem, necessitating the search for new antimicrobial agents. Silver nanoparticles (Ag-NPs) have been proposed as a new generation of antimicrobial agents, showing antimicrobial activity against multi-drug resistant Gram-positive and Gram-negative pathogens. Egyptian Streptomyces roseolus was used for the first time to biomediate the synthesis of Ag-NPs, and characterization confirmed the presence of bioactive functional groups acting as bioreducing/stabilizing agents for Ag-NPs.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2022)
Article
Polymer Science
Chien-Ying Lee, Yung-Chuan Ho, Shiuan-Shinn Lee, Yi-Ching Li, Mei-Yu Lai, Yu-Hsiang Kuan
Summary: This study aims to clarify the mechanisms underlying HEMA-induced cytotoxicity and apoptosis in macrophages. The results showed that HEMA induced concentration-dependent cell toxicity and mediated genotoxicity and apoptosis through mitochondrial dysfunction, intrinsic caspase pathway activation, and intracellular reactive oxygen species accumulation.
Article
Chemistry, Multidisciplinary
Nadezhda Samoilova, Maria Krayukhina, Alexander Naumkin, Nelya Anuchina, Dmitry Popov
Summary: The study proposed composites containing silver nanoparticles and silver cations, which were found to be active against a wide range of opportunistic microorganisms. The introduction of silver cations into the system reduced the charge of the polymer matrix and potentiated the activity of the silver nanoparticles.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Environmental Sciences
Christian Khalil, Joe Braham Chahine, Tony Haykal, Cynthia Al Hageh, Sandra Rizk, Rony S. Khnayzer
Summary: This study used a novel dynamic exposure methodology to determine the acute toxicological impacts of electronic cigarettes consumption, showing that acute exposure could induce significant cytotoxicity and apoptotic induction in cells. Further research is needed to establish the chronic toxicity from long-term e-cigarette consumption.
Article
Biochemistry & Molecular Biology
Yu Tao, Tomas Aparicio, Mingqiang Li, Kam W. Leong, Shan Zha, Jean Gautier
Summary: The study demonstrates that silver nanoclusters AgNCs can inhibit genomic DNA replication and disrupt the DNA replication checkpoint, but do not affect other cellular functions.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mehmet Sarimahmut, Serap Celikler
Summary: Anatolia is characterized by its rich floristic diversity and high rates of endemism. In this study, eight plant species from northwestern Anatolia were tested for their anti-growth properties in breast cell lines, showing that Achillea multifida (AME) and Astragalus sibthorpianus (ASE) exhibited the most promising results. AME induced DNA damage in a time-dependent manner, while ASE displayed selective cytotoxicity against breast cancer cells. These findings emphasize the medicinal and economic potential of these plant species and the importance of their conservation.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Nanoscience & Nanotechnology
Nobutaka Hanagata, Xianglan Li, Min-Hua Chen, Jie Li, Shinya Hattori
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2018)
Article
Chemistry, Applied
Zhengfang Tian, Xia Yu, Zhijun Ruan, Min Zhu, Yufang Zhu, Nobutaka Hanagata
MICROPOROUS AND MESOPOROUS MATERIALS
(2018)
Article
Biochemistry & Molecular Biology
Souichi Ikeno, Naoko Nakano, Keigo Sano, Takashi Minowa, Wataru Sato, Ryosuke Akatsu, Nobuo Sakata, Nobutaka Hanagata, Makiko Fujii, Fumiko Itoh, Susumu Itoh
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Chemistry, Analytical
Shanmugavel Chinnathambi, Nobutaka Hanagata
Article
Medicine, Research & Experimental
Kouhei Yamamoto, Shinya Abe, Ayaka Honda, Jun Hashimoto, Yuuki Aizawa, Sachiko Ishibashi, Taro Takemura, Nobutaka Hanagata, Masahide Yamamoto, Osamu Miura, Morito Kurata, Masanobu Kitagawa
LABORATORY INVESTIGATION
(2020)
Article
Materials Science, Multidisciplinary
Weijia Wang, Chao Ma, Xingtang Zhang, Jiajia Shen, Nobutaka Hanagata, Jiangtao Huangfu, Mingsheng Xu
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
(2019)
Article
Clinical Neurology
Kazuhiko Watabe, Yoichiro Kato, Miho Sakuma, Makiko Murata, Motoko Niida-Kawaguchi, Taro Takemura, Nobutaka Hanagata, Mari Tada, Akiyoshi Kakita, Noriyuki Shibata
Article
Biochemistry & Molecular Biology
Anh Thi Tram Tu, Kazuaki Hoshi, Kazunori Ikebukuro, Nobutaka Hanagata, Tomohiko Yamazaki
Article
Chemistry, Multidisciplinary
Hongxin Wang, Han Zhang, Bo Da, Dabao Lu, Ryo Tamura, Kenta Goto, Ikumu Watanabe, Daisuke Fujita, Nobutaka Hanagata, Junko Kano, Tomoki Nakagawa, Masayuki Noguchi
Summary: Cellular mechanical properties can serve as potential cancer biomarkers for objective cytology, with a classifier trained through high dimensional mechanome data achieving a classification accuracy of 89% and instrument-independent robustness. This approach also demonstrated a signal-to-noise ratio 8 times higher than traditional morphology-based methods in differentiating precancerous cells from normal cells.
Article
Multidisciplinary Sciences
Nobutaka Hanagata, Taro Takemura, Keiko Kamimura, Toshiaki Koda
SCIENTIFIC REPORTS
(2020)
Article
Pharmacology & Pharmacy
Tsu-Man Chiu, Ping-Chun Hsu, Mohd Yaqub Khan, Cheng-An J. Lin, Chun-Hung Lee, Tsai-Ching Hsu, Min-Hua Chen, Nobutaka Hanagata
Summary: Warts are a common skin problem caused by viral infection. Current treatments for warts, such as ablating tissue or interrupting cellular division, can be invasive or cause skin discomfort. Imiquimod is a synthetic compound used topically to treat anogenital warts, but it has limitations such as low skin permeability and side effects. Microneedle technology shows promise in overcoming these barriers and providing painless and personalized treatment options.
Article
Chemistry, Multidisciplinary
Irem Nur Gamze Ozbilgin, Tomohiko Yamazaki, Junpei Watanabe, Hong-Tao Sun, Nobutaka Hanagata, Naoto Shirahata
Summary: We report carboxy-terminated silicon quantum dots (SiQDs) that are highly soluble in water due to the high coverage of surface monolayers, exhibit bright light emission with high photoluminescence quantum yields (PLQYs), show long-term stability in PL property for cell monitoring, have low toxicity to cells, and display a high photothermal response.
Article
Chemistry, Multidisciplinary
Shanmugavel Chinnathambi, Nobutaka Hanagata, Tomohiko Yamazaki, Naoto Shirahata
Article
Engineering, Electrical & Electronic
Tao Liang, Mohammad Rezwan Habib, Han Xiao, Shuang Xie, Yuhan Kong, Cui Yu, Hideo Iwai, Daisuke Fujita, Nobutaka Hanagata, Hongzheng Chen, Zhihong Feng, Mingsheng Xu
ACS APPLIED ELECTRONIC MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Shanmugavel Chinnathambi, Subramani Karthikeyan, Nobutaka Hanagata, Naoto Shirahata