Article
Pharmacology & Pharmacy
Priscila de Souza Furtado, Alana Agnes Silva Camargo de Oliveira, Pryscila Santiago Rodrigues, Anna Rita Santiago de Paula Goncalves, Anna Raphaella Autran Colaco, Sandro Pinheiro da Costa, Mariana Muniz da Paz, Paloma Wetler Meireles Carreiros Assumpcao, Luciana Pereira Rangel, Alice Simon, Flavia Almada do Carmo, Lucio Mendes Cabral, Plinio Cunha
Summary: This study developed and characterized RVX-loaded PLGA/SLS or DMAB nanoparticles, and evaluated their pharmacological and toxicological profiles. The nanoparticles showed high encapsulation efficiency and suitable yields, with rapid initial liberation and sustained release in different pH environments. Importantly, in vivo evaluations demonstrated a time-dependent antithrombotic effect of RVX-loaded SLS or DMAB nanoparticles surpassing the free form of RVX, with no hemolytic or cytotoxic effects observed at various concentrations. These findings suggest that RVX-loaded SLS or DMAB nanoparticles are promising innovative therapeutic alternatives for thromboembolic diseases.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Jingrong Gao, Ankita Kumari, Xin-An Zeng, Siewyin Chan, Muhammad Adil Farooq, Mahafooj Alee, Shaheer Hasan Khan, Abdul Rahaman, Shan He, Xiong Xin, Tariq Mehmood
Summary: Breast cancer is the second most common cancer worldwide, and triple-negative breast cancer (TNBC) is characterized by the absence of three receptors. Various therapies, including natural compounds and nanoparticles, have been developed to combat TNBC. In this study, we synthesized PLGA-TQ-NPs and coated them with CS, which showed enhanced anti-cancer effects against TNBC cell lines.
FRONTIERS IN CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Zezhi Lin, Zunting Pang, Ke Zhang, Zhengjie Qian, Zhenjing Liu, Jianjun Zhang, Yuan Gao, Yuanfeng Wei
Summary: In this study, it was found that the addition of surfactant sodium lauryl sulfate (SLS) can increase the dissolution of insoluble drugs, but it significantly decreases the dissolution of crystalline lurasidone hydrochloride (LH). The insoluble single-phase amorphous LH-SLS complex formed during dissolution in 0.1% SLS aqueous solution, leading to gel formation and suppression of LH dissolution. An innovative strategy was developed to mitigate the inhibiting effect of SLS on LH dissolution based on potential competitive interactions.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Environmental Sciences
Yong-Hyun Kim, Kyuhong Lee
Summary: Experimental findings show that shampoo aerosols may be generated during use, with higher mass concentrations observed compared to water aerosols. The volatile organic compounds in shampoo aerosols could pose inhalation safety risks.
ENVIRONMENTAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Yiwang Guo, Changquan Calvin Sun
Summary: This study examined two formulation strategies to mitigate the negative effect of sodium lauryl sulfate (SLS) on the dissolution of p-aminobenzoic acid (PABA), which are increasing the microenvironment pH and reducing the critical micelle concentration (CMC) of SLS.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Jan Patera, Pavla Nemeckova, Petr Zamostny
Summary: This study investigates different approaches for enhancing drug dissolution and finds that for hydrophobic drugs, the surface properties of particles are crucial for drug release during dissolution, rather than just particle size. Co-milling with sodium lauryl sulfate is shown to be more effective in improving drug release rate.
Review
Chemistry, Multidisciplinary
Eduarda Blasi Magini, Luiza de Oliveira Matos, Raissa Borges Curtarelli, Mariane Beatriz Sordi, Gabriel Leonardo Magrin, Carlos Flores-Mir, Reinhard Gruber, Ariadne Cristiane Cabral Cruz
Summary: This systematic review evaluates the doses of simvastatin used in preclinical studies and their impact on bone regeneration. The results suggest that lower doses of simvastatin can consistently promote bone formation, but there is no significant correlation between the relative bone gain and the doses of simvastatin. However, the interpretation of these findings should consider factors such as scaffold heterogeneity, defect anatomy, observation period, and evaluation method.
APPLIED SCIENCES-BASEL
(2022)
Review
Materials Science, Biomaterials
Jagan Mohan Dodda, Tomas Remis, Sadiku Rotimi, Yi-Cheun Yeh
Summary: This article provides an overview of PLGA-based conjugates in cancer research, focusing on their roles as targeted drug carriers and sustained drug controllers. The preparation and drug encapsulation of PLGA nanoparticles and FA-PEG-PLGA conjugates are discussed, with emphasis on the associated chemistries and biocompatibility. This review offers a deeper understanding of PLGA-conjugated materials for successful material design and biomedical applications.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Nutrition & Dietetics
Chunmei Li, Yu Zhou, Meng Yuan, Yawen Yang, Ruilong Song, Gang Xu, Gang Chen
Summary: The study demonstrated that AST@PLGA nanoparticles have good stability and can effectively alleviate symptoms of colitis. These nanoparticles have the potential to be used as functional foods in the future.
FRONTIERS IN NUTRITION
(2023)
Article
Polymer Science
Polina Yu. Algebraistova, Andrey V. V. Basko, Anna N. N. Ilyasova, Tatyana N. N. Lebedeva, Anton V. V. Mironov, Konstantin V. V. Pochivalov, Vladimir K. K. Popov
Summary: This paper studies the phase separation and structure formation processes in hydrophobic PLGA solutions in hydrophilic TG when they contact with water. Methods including cloud point methodology, high-speed video recording, differential scanning calorimetry, and microscopy were used to analyze the behavior and structure evolution process of PLGA/TG mixtures in water and nonsolvent. The phase diagram of the PLGA/TG/water system was constructed and the composition of PLGA/TG mixture undergoing glass transition was determined. The study provides insights into the structure formation mechanism and opportunities for controlled fabrication of bioresorbable structures.
Article
Polymer Science
Maria Herrero-Herrero, Jose Antonio Gomez-Tejedor, Ana Valles-Lluch
Summary: Tailored membranes with a fiber diameter of 1.8 μm were electrospun from PLGA and PCLGA solutions by adjusting electrospinning and polymer solution parameters. PCLGA, with its amorphous morphology, required the addition of a salt to increase conductivity for successful electrospinning, presenting notable difficulties due to its structure. Interestingly, PCLGA, with a higher glycolic acid molar fraction, could be successfully electrospun, a feat not previously reported.
Article
Polymer Science
Hamed Alipour, Aliakbar Alizadeh, Negar Azarpira, Ahmad Saudi, Omid Alavi, Nader Tanideh, Farzaneh Dehghani
Summary: In this study, electrospun scaffolds loaded with different concentrations of Fingolimod were fabricated and their morphology, physicochemical properties, and effects on cell viability were investigated. The results showed that the scaffold with 0.01% Fingolimod had better cell survival, suggesting it could be a suitable candidate for peripheral nerve regeneration.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Nanoscience & Nanotechnology
Afif Hethnawi, Taha Karaki, Yalda Zamani Keteklahijani, Morteza Chehelamirani, Azfar Hassan, Nashaat N. Nassar
Summary: A three-in-one nanoflocculent was developed to enhance settling and dewatering of oil sands tailings, which showed improved performance compared to traditional anionic PAM.
ACS APPLIED NANO MATERIALS
(2022)
Article
Dermatology
Simon G. Danby, Paul V. Andrew, Rosie N. Taylor, Linda J. Kay, John Chittock, Abigail Pinnock, Intisar Ulhaq, Anna Fasth, Karin Carlander, Tina Holm, Michael J. Cork
Summary: The study reveals that not all emollient creams are the same for eczema patients. The commonly prescribed paraffin-based emollient cream has no effect on the skin's barrier, while the urea-glycerol cream significantly improves the skin's barrier and provides protection. Different emollient creams have different effects on the skin, and only certain types have the ability to improve the skin's barrier and protect against irritants that trigger eczema.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Article
Engineering, Chemical
Mariangela Guastaferro, Lucia Baldino, Stefano Cardea, Ernesto Reverchon
Summary: Supercritical CO2-assisted electrospray was used to achieve sustained release of ceftriaxone sodium from polylactic acid nanoparticles. By adjusting the process conditions, the release time was increased by 240 times.
Article
Chemistry, Multidisciplinary
Bijay Kumar Poudel, Jong Oh Kim, Jeong Hoon Byeon
Article
Nanoscience & Nanotechnology
Biki Gupta, Hima Bindu Ruttala, Bijay Kumar Poudel, Shiva Pathak, Shobha Regmi, Milan Gautam, Kishwor Poudel, Min Hyun Sung, Wenquan Ou, Sung Giu Jin, Jee-Heon Jeong, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
ACS APPLIED MATERIALS & INTERFACES
(2018)
Article
Chemistry, Multidisciplinary
Bijay Kumar Poudel, Kyung-Oh Doh, Jeong Hoon Byeon
Article
Chemistry, Multidisciplinary
Bijay Kumar Poudel, Kyung-Oh Doh, Jeong Hoon Byeon
Article
Chemistry, Multidisciplinary
Biki Gupta, Bijay Kumar Poudel, Shobha Regmi, Shiva Pathak, Hima Bindu Ruttala, Milan Gautam, Gyeong Jin An, Jee-Heon Jeong, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
PHARMACEUTICAL RESEARCH
(2018)
Article
Materials Science, Multidisciplinary
Thiruganesh Ramasamy, Hima Bindu Ruttala, Pasupathi Sundaramoorthy, Bijay Kumar Poudel, Yu Seok Youn, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
NPG ASIA MATERIALS
(2018)
Article
Engineering, Biomedical
Biki Gupta, Bijay Kumar Poudel, Hima Bindu Ruttala, Shobha Regmi, Shiva Pathak, Milan Gautam, Sung Giu Jin, Jee-Heon Jeong, Han-Gon Choi, Sae Kwang Ku, Chul Soon Yong, Jong Oh Kim
ACTA BIOMATERIALIA
(2018)
Article
Pharmacology & Pharmacy
Zar Chi Soe, Bijay Kumar Poudel, Hanh Thuy Nguyen, Raj Kumar Thapa, Wenquan Ou, Milan Gautam, Kishwor Poudel, Sung Giu Jin, Jee-Heon Jeong, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Article
Nanoscience & Nanotechnology
Bijay Kumar Poudel, Jungho Hwang, Sae Kwang Ku, Jong Oh Kim, Jeong Hoon Byeon
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Engineering, Biomedical
Milan Gautam, Raj Kumar Thapa, Bijay Kumar Poudel, Biki Gupta, Hima Bindu Ruttala, Hanh Thuy Nguyen, Zar Chi Soe, Wenquan Ou, Kishwor Poudel, Han-Gon Choi, Sae Kwang Ku, Chul Soon Yong, Jong Oh Kim
ACTA BIOMATERIALIA
(2019)
Article
Engineering, Biomedical
Hima Bindu Ruttala, Thiruganesh Ramasamy, Bijay Kumar Poudel, Raghu Ram Teja Ruttala, Sung Giu Jin, Han-Gon Choi, Sae-Kwang Ku, Chul Soon Yong, Jong Oh Kim
ACTA BIOMATERIALIA
(2020)
Review
Anatomy & Morphology
Bijay K. Poudel, Marie-Claude Robert, Fiona C. Simpson, Kamal Malhotra, Ludovic Jacques, Paul LaBarre, May Griffith
Summary: Corneal blindness is the fourth leading cause of global blindness, with over 90% of cases occurring in low- and middle-income regions. While corneal transplantation is effective, the shortage of corneal graft tissue in many LMIRs limits access to this treatment option. Various biomaterial approaches, including in situ tissue regeneration, show promise for treating corneal injuries and diseases, potentially offering alternatives to organ transplantation and improving patient outcomes.
CELLS TISSUES ORGANS
(2022)
Review
Ophthalmology
May Griffith, Bijay Kumar Poudel, Kamal Malhotra, Naoufal Akla, Miguel Gonzalez-Andrades, David Courtman, Victor Hu, Emilio Alarcon
EXPERT REVIEW OF OPHTHALMOLOGY
(2020)
Article
Medicine, Research & Experimental
Wenquan Ou, Jeong Hoon Byeon, Zar Chi Soe, Bo Kyun Kim, Raj Kumar Thapa, Biki Gupta, Bijay Kumar Poudel, Sae Kwang Ku, Chul Soon Yong, Jong Oh Kim
Article
Biophysics
Biki Gupta, Shiva Pathak, Bijay Kumar Poudel, Shobha Regmi, Hima Bindu Ruttala, Milan Gautam, Jong Seong Lee, Jee-Heon Jeong, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
COLLOIDS AND SURFACES B-BIOINTERFACES
(2017)