Article
Immunology
Sophie Dennhardt, Wiebke Pirschel, Bianka Wissuwa, Diana Imhof, Christoph Daniel, Jan T. Kielstein, Isabel Hennig-Pauka, Kerstin Amann, Florian Gunzer, Sina M. Coldewey
Summary: Hemolytic-uremic syndrome (HUS) is a systemic complication of infections with Shiga toxin-producing Escherichia coli, characterized by microangiopathic hemolytic anemia and acute kidney injury. This study found that endogenous erythropoietin (EPO) levels were elevated in HUS patients and animal models. Administration of EPO and its analog pHBSP improved survival and attenuated renal oxidative stress in mice with HUS. Therefore, repurposing EPO for the treatment of hemolytic anemia in HUS should be further investigated in clinical trials.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Mohammed A. Al-Onaizi, Peter Theriault, Sarah Lecordier, Paul Prefontaine, Serge Rivest, Ayman ElAli
Summary: Using the non-erythropoietic analogue ARA 290 early in the treatment of an early-onset model in mice showed promising results in slowing down Aβ pathology progression and improving cognitive functions. ARA 290 specifically increased the levels of patrolling monocytes which are involved in clearing Aβ, thus reducing the overall Aβ burden in the brain.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Medicine, Research & Experimental
Naser Mohtavinejad, Maliheh Hajiramezanali, Mehdi Akhlaghi, Ahmad Bitarafan-Rajabi, Nazila Gholipour
Summary: This study developed a modified ARA-290 variant with improved serum stability and demonstrated its excellent ability for ischemic cardiac imaging. The radiolabeled peptide showed high accumulation in ischemic regions, suggesting it could be a promising candidate for early diagnosis of cardiac ischemia.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2021)
Article
Fisheries
Yinan Jiang, Yuting Wang, Yingying Zhang, Hui Yang
Summary: A novel scavenger receptor B (PcSRB) was identified in the Chinese mitten crab, which plays an important role in immune defense, particularly in the recognition and binding of pathogens.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Immunology
Yuanyuan Wu, Lili Huang, Weili Sai, Fei Chen, Yu Liu, Cheng Han, Joanna M. Barker, Zinah D. Zwaini, Mark P. Lowe, Nigel J. Brunskill, Bin Yang
Summary: The regulation of neutrophil phagocytosis in renal ischemia-reperfusion (IR) injury by properdin and innate repair receptor is still unknown. A peptide derived from erythropoietin receptor (EPOR) and beta common receptor (beta cR) can improve functional and structural damage in both wild-type and properdin knockout mice. This study demonstrates that the peptide can enhance the phagocytic function of tubular epithelial cells and promote kidney repair through upregulation of EPOR/beta cR triggered by IR and properdin deficiency.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Yu Cao, Florian Kuemmel, Elke Logemann, Jan M. Gebauer, Aaron W. Lawson, Dongli Yu, Matthias Uthoff, Beat Keller, Jan Jirschitzka, Ulrich Baumann, Kenichi Tsuda, Jijie Chai, Paul Schulze-Lefert
Summary: In plants, the coevolution between host and pathogen is reflected in adaptive genetic changes in host immune receptors and pathogen effectors. This study focuses on the RNase-like effector family RALPH in grass powdery mildew fungi and reveals variations in the structures and activities of the RALPH effectors. The findings provide insights into the escape of powdery mildew fungi from host recognition and the acquisition of diverse virulence functions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Zhen-Hong Yang, Si-Jia Zhang, Hai-Ping Zhao, Fang-Fang Li, Zhen Tao, Yu-Min Luo, Rong-Liang Wang
Summary: This study investigated the effects of erythropoietin (EPO) on the differentiation of neural stem cells (NSCs)/neural progenitors (NPs) in hypoxic-ischemic injury. Results showed that EPO promoted the differentiation of NSCs/NPs into oligodendrocytes and astrocytes, while inhibiting neuronal differentiation. The EPO receptor/β common receptor heterodimer was found to be present on the surface of fetal NSCs/NPs and involved in glial differentiation. The study provides insights into the potential mechanisms of EPO in treating hypoxic-ischemic injury.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Multidisciplinary Sciences
Aiko Watanabe, Hiroyuki Koike, Naoki Kumagami, Shigeki Shimba, Ichiro Manabe, Yumiko Oishi
Summary: After a muscle injury, the process of inflammation, repair, and regeneration is controlled by various myeloid cell types. The role of the transcription factor Arntl in this process was investigated using myeloid cell-specific Arntl conditional knockout mice. The study found that Arntl expression in myeloid cells is required for the recruitment of neutrophils and monocytes, thus playing a crucial role in skeletal muscle regeneration.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Yangyang Wang, Kuo Qu, Wenting Lu, Peiyan Zhao, Zhe Wang, Cuiyun Cui, Ye Liu, Ming Yang, Yongli Yu, Liying Wang
Summary: Neutrophils play a crucial role in immune responses, and it has been found that they can regulate antibody reactions induced by vaccines at immunization sites. Inhibiting BAFF in neutrophils can weaken B cell activation and antibody production.
Article
Biotechnology & Applied Microbiology
Ming Geng, Yishan Hua, Yu Liu, Jian Quan, Xueting Hu, Peng Su, Yingying Li, Xin Liu, Qingwei Li, Ting Zhu
Summary: The TICAM-a and TICAM-b genes in Lampetra japonica are likely ancestral genes of vertebrate TICAM genes, showing functional divergence during immune responses. These genes might activate nuclear factor xB expression by forming a signal transduction complex, but the signaling pathway in lamprey could rely on TRAF3 rather than TRAF6, unlike in mammals.
Article
Fisheries
Yangyu Li, Rong Huang, Liangming Chen, Yangyang Li, Yongming Li, Lanjie Liao, Libo He, Zuoyan Zhu, Yaping Wang
Summary: The full-length cDNA sequences of SR-B2a and SR-B2b from grass carp were cloned and designated as CiSR-B2a and CiSR-B2b. Both CiSR-B2a and CiSR-B2b were found to be expressed in various tissues, with the highest levels in the hepatopancreas. Following infection with Grass Carp Reovirus (GCRV), the expression of CiSR-B2a and CiSR-B2b in the spleen was significantly upregulated, suggesting their importance in the infection processes of GCRV.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Immunology
Kelly M. Cautivo, Peri R. Matatia, Carlos O. Lizama, Nicholas M. Mroz, Madelene W. Dahlgren, Xiaofei Yu, Julia Sbierski-Kind, Marcela T. Taruselli, Jeremy F. Brooks, Adam Wade-Vallance, Sofia E. Caryotakis, Anthony A. Chang, Hong-Erh Liang, Julie Zikherman, Richard M. Locksley, Ari B. Molofsky
Summary: Allergic immunity is regulated by ILC2s and Th2 cells at various barriers, and their dynamic repositioning during immune perturbations is observed. Allergic inflammation drives the invasion of lung and liver non-adventitial parenchyma by ILC2s and Th2 cells. Concurrent type 1 and type 2 mixed inflammation can block the parenchymal trafficking of ILC2s and subsequent cell survival by IFNg from type 1 lymphocytes. The confinement of ILC2s and Th2 cells to adventitia limits mortality by type 1 pathogen Listeria monocytogenes.
Review
Immunology
Yanqin Du, Jun Wu, Jia Liu, Xin Zheng, Dongliang Yang, Mengji Lu
Summary: Chronic hepatitis B virus (HBV) infection is a significant global burden, and Toll-like receptors (TLRs) play a crucial role in immune response. However, HBV has developed strategies to inhibit TLR responses, limiting host immune response and promoting viral persistence. Recent studies indicate that stimulation of TLR signaling pathway enhances host immune response and suppresses HBV replication. These findings provide important insights for the use of TLR agonists as immunomodulators in the functional cure of HBV.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Carolin Torregroza, Chiara O. Glashoerster, Katharina Feige, Martin Stroethoff, Annika Raupach, Andre Heinen, Markus W. Hollmann, Ragnar Huhn
Summary: The study found that Mannitol achieves cardioprotective effects through activation of the adenosine A1 receptor, rather than the protein kinases Akt and PKG. Akt and PKG are not involved in the preconditioning cardioprotection induced by Mannitol.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Min Zheng, Rajendra Karki, Evan Peter Williams, Dong Yang, Elizabeth Fitzpatrick, Peter Vogel, Colleen Beth Jonsson, Thirumala-Devi Kanneganti
Summary: The study revealed that the envelope protein of SARS-CoV-2 is sensed by TLR2, leading to the production of inflammatory cytokines, and the severity of the disease is associated with the expression of TLR2 and MYD88. The findings demonstrate the critical role of TLR2 signaling in promoting proinflammatory cytokine production during coronavirus infection, providing new insights for therapeutic strategies against the ongoing COVID-19 pandemic.
Review
Cardiac & Cardiovascular Systems
Guglielmo Gallone, Luca Baldetti, Filippo Angelini, Andrea Saglietto, Matteo Bellettini, Alessandro Beneduce, Viola Ranotti, Mauro Chiarito, Pier Pasquale Leone, Matteo Pagnesi, Ovidio De Filippo, Federico Landra, Francesco Bruno, Giorgio Marengo, Massimo Collino, Giuseppe Ferrante, Giulio G. Stefanini, Antonio Colombo, Rasha Al-Lamee, Darrel P. Francis, Marc E. Jolicoeur, Timothy D. Henry, Francesco Giannini, Fabrizio D'Ascenzo, Gaetano Maria De Ferrari
Summary: This study conducted a systematic review and meta-analysis to quantify the effect of placebo on symptoms, life quality, and functional outcomes in randomized placebo-controlled trials of symptomatic stable coronary artery disease. The results showed that placebo had a substantial effect on various metrics, but the size of the placebo effect varied significantly.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Article
Surgery
Nikita M. Patel, Filipe R. M. B. Oliveira, Hanna Pillmann Ramos, Eleonora Aimaretti, Gustavo Ferreira Alves, Sina M. Coldewey, Massimo Collino, Regina Sordi, Christoph Thiemermann
Summary: The aim of this study was to investigate the potential of BTK inhibitors acalabrutinib and fenebrutinib in reducing MODS in acute hemorrhagic shock rat models and to determine their effects on BTK, NF-kappa B, and NLRP3 activation in HS. The results showed that treatment with either acalabrutinib or fenebrutinib attenuated organ injury and dysfunction in acute HS models and reduced the activation of BTK, NF-kappa B, and NLRP3 pathways in the kidney. These findings suggest that BTK inhibitors may be a potential therapeutic approach for MODS after trauma and/or hemorrhage.
Article
Biochemistry & Molecular Biology
Zamzam Awida, Almog Bachar, Hussam Saed, Anton Gorodov, Nathalie Ben-Califa, Maria Ibrahim, Albert Kolomansky, Jennifer Ana Iden, Liad Graniewitz Visacovsky, Tamar Liron, Sahar Hiram-Bab, Michael Brines, Yankel Gabet, Drorit Neumann
Summary: The study shows that Cibinetide (CIB) can increase bone density and inhibit osteoclastogenesis in mice, suggesting it as a potential candidate for the treatment of bone loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Pharmacology & Pharmacy
Michael Brines, Stephana Carelli, Michele Samaja, Edith Schneider M. Gasser
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Huan Yang, Sam J. George, Dane A. Thompson, Harold A. Silverman, Tea Tsaava, Aisling Tynan, Valentin A. Pavlov, Eric H. Chang, Ulf Andersson, Michael Brines, Sangeeta S. Chavan, Kevin J. Tracey
Summary: Recent studies have shown that famotidine has anti-inflammatory effects and can attenuate the clinical course of COVID-19 by preventing cytokine storm. The mechanism of action involves activation of the inflammatory reflex, which inhibits inflammation and is mediated by alpha 7 nicotinic acetylcholine receptors (alpha 7nAChR).
MOLECULAR MEDICINE
(2022)
Article
Geriatrics & Gerontology
Sandra Palus, Yulia Elkina, Tanja Braun, Stephan von Haehling, Wolfram Doehner, Stefan D. Anker, Anthony Cerami, Michael Brines, Jochen Springer
Summary: ARA 284 can reverse the loss in cancer cachexia, improve spontaneous activity, induce anabolic pathways, increase muscle mass, and enhance survival in animals.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Medicine, General & Internal
Elisabeth Zechendorf, Katharina Schroeder, Lara Stiehler, Nadine Frank, Christian Beckers, Sandra Kraemer, Michael Dreher, Alexander Kersten, Christoph Thiemermann, Gernot Marx, Tim-Philipp Simon, Lukas Martin
Summary: Heparanase activity and heparan sulfate levels correlate with the severity and outcomes of COVID-19, and may be helpful in predicting clinical progression and outcomes in patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemical Research Methods
Simone Squara, Friederike Manig, Thomas Henle, Michael Hellwig, Andrea Caratti, Carlo Bicchi, Stephen E. Reichenbach, Qingping Tao, Massimo Collino, Chiara Cordero
Summary: Comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry (GC x GC-TOFMS) is a powerful analytical platform for chemical investigations of complex biological samples. This study optimized a data processing strategy to compensate for 2D pattern misalignments and detector response fluctuations in saliva samples analyzed over 2 years. The strategy was trained on two batches of samples and achieved reliable peak detection and cross-alignment using a combination of untargeted and targeted pattern recognition algorithms and supervised operation with affine functions. Z-score normalization of the mass spectral total useful signal (MSTUS) was found to be the most promising strategy for cross-comparative analysis and data fusion.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Nolan M. M. Winicki, Alay P. P. Nanavati, Christopher H. H. Morrell, Jack M. M. Moen, Jessie E. E. Axsom, Melissa Krawczyk, Natalia N. N. Petrashevskaya, Max G. G. Beyman, Christopher Ramirez, Irene Alfaras, Sarah J. J. Mitchell, Magdalena Juhaszova, Daniel R. R. Riordon, Mingyi Wang, Jing Zhang, Anthony Cerami, Michael Brines, Steven J. J. Sollott, Rafael De Cabo, Edward G. G. Lakatta
Summary: ARA290 (cibinetide) alleviates age-related cardiac inflammation and cellular damage, improves structural and functional changes in the cardiovascular system, and promotes overall health and longevity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Correction
Biochemical Research Methods
Simone Squara, Friederike Manig, Thomas Henle, Michael Hellwig, Andrea Caratti, Carlo Bicchi, Stephen E. Reichenbach, Qingping Tao, Massimo Collino, Chiara Cordero
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Clinical Neurology
Stavros Zanos, Despoina Ntiloudi, John Pellerito, Richard Ramdeo, John Graf, Kirk Wallace, Victoria Cotero, Jeff Ashe, Jessica Moon, Meghan Addorisio, David Shoudy, Thomas R. Coleman, Michael Brines, Chris Puleo, Kevin J. Tracey, Sangeeta S. Chavan
Summary: Focused ultrasound stimulation (FUS) has been found to be effective in noninvasive modulation of inflammatory response in humans. The study demonstrates that both continuously swept and focused pulsed ultrasound can suppress inflammation without adverse effects, regardless of the ultrasound energy level and target site, providing potential implications for noninvasive treatment of inflammatory disorders.
Article
Biochemistry & Molecular Biology
Wayne Chadwick, Stuart Maudsley, William Hull, Enes Havolli, Eugene Boshoff, Mark D. W. Hill, Pascal J. D. Goetghebeur, David C. Harrison, Sohaib Nizami, David C. Bedford, Gareth Coope, Katia Real, Christoph Thiemermann, Peter Maycox, Mark Carlton, Sarah L. Cole
Summary: Sporadic Alzheimer's disease (sAD) is a global economic and healthcare burden, and novel experimental models are needed for effective therapies. The oDGal mouse model presents AD-like pathologies and cognitive deficits, and can be improved with N-acetyl-cysteine (NaC) treatment. This non-genetic AD model could benefit the development of therapeutics for sAD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Dane A. Thompson, Tea Tsaava, Arvind Rishi, Sandeep Nadella, Lopa Mishra, David A. Tuveson, Valentin A. Pavlov, Michael Brines, Kevin J. Tracey, Sangeeta S. Chavan
Summary: Inflammation is a self-amplifying process that can result in tissue damage. The nervous system has evolved to detect inflammatory signals and respond with anti-inflammatory processes, including the cholinergic anti-inflammatory pathway mediated by the vagus nerve. This study used optogenetics to selectively activate vagus nerve fibers originating in the brainstem and found that stimulation of cholinergic neurons in the dorsal motor nucleus of the vagus significantly reduced the severity of pancreatitis.
FRONTIERS IN IMMUNOLOGY
(2023)
Meeting Abstract
Endocrinology & Metabolism
R. Mastrocola, D. Collotta, F. El-Masri, C. Murzio, E. Aimaretti, M. Aragno, J. Frank, M. Collino