Article
Plant Sciences
Yan Wu, Xin Yang, Yuanyuan Ju, Fei Zhao
Summary: This study found that fraxinol has significant therapeutic effects in the treatment of acute lung injury (ALI). It works by balancing the ACE-Ang II-AT1R and ACE2-Ang (1-7)-Mas axis and inhibiting the activation of NLRP3 inflammasome.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xin Lv, Tingting Yao, Rongling He, Yijun He, Mengyu Li, Yuanyuan Han, Yan Zhang, Lingzhi Long, Guoliang Jiang, Xiaoyun Cheng, Yanyun Xie, Ling Huang, Zhangzhe Peng, Gaoyun Hu, Qianbin Li, Lijian Tao, Jie Meng
Summary: Fluorofenidone demonstrates protective effects against LPS-induced ALI by alleviating lung tissue injury, reducing inflammation, and inhibiting the activation of the MAPK/NF-κB signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Liming Wang, Tian Jiang, Yilin Yang, Junjie Mao, Qiong Wang, Ronghuan Yu, Baoqing Wang, Jun Yin
Summary: The study discovered that angiotensin (Ang)-(1-7) attenuates acute lung injury (ALI) by regulating neutrophil activation, providing a potential therapeutic strategy.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Review
Cell Biology
Yasmin Begum, Anuradha Pandit, Snehasikta Swarnakar
Summary: Gynecological illnesses contribute a significant portion to the global disease burden, particularly affecting women of reproductive age. Metalloproteinases play crucial roles in the development of gynecological disorders, offering potential targets for therapeutic interventions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Patricia Passaglia, Felipe de Lima Faim, Marcelo Eduardo Batalhao, Angelita Maria Stabile, Lusiane Maria Bendhack, Jose Antunes-Rodrigues, Riccardo Lacchini, Evelin Capellari Carnio
Summary: The study found that Ang-(1-7) promotes a systemic anti-inflammatory effect through central activation of the Mas receptor and the humoral pathway mediated by AVP, restoring mean arterial blood pressure in endotoxemic animals without affecting heart rate.
Article
Medicine, Research & Experimental
Yun Xu, Yi Li
Summary: The study revealed that miR-28-3p plays a crucial role in regulating ACE2 ectodomain shedding through ADAM17 in 293T cells treated with SARS-CoV-2 S-protein, suggesting a potential therapeutic role of miR-28-3p mimic in the prevention and treatment of SARS-CoV-2 patients.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Xiaolei Gong, Limin Zhu, Jinlong Liu, Chunxiang Li, Zhuoming Xu, Jinfen Liu, Haibo Zhang
Summary: The novel lncRNA MIR3142HG plays a crucial role in LPS-induced ALI by regulating the miR-450b-5p/HMGB1 signaling pathway, indicating its potential as a therapeutic target for ALI treatment.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Xiaohui Liu, Yating Sun, Qilu Wei, Wuqiang Jiang, Ming Jiao, Junteng Yan, Run Tian, Pei Yang, Kunzheng Wang, Chunsheng Wang
Summary: This study investigated the therapeutic effects and potential mechanisms of the angiotensin-converting enzyme inhibitor (ACEI) captopril (CAP) in a rat model of glucocorticoid-induced femoral head necrosis (GIONFH). The results showed that CAP promoted cell proliferation, reduced apoptosis and reactive oxygen species accumulation, and promoted osteogenesis. In vivo experiments showed that CAP prevented osteonecrosis, attenuated inflammation levels, and corrected bone metabolism and bone loss. The findings suggest that CAP exerts anti-inflammatory, antioxidant, anti-apoptotic, and osteoprotective effects against GIONFH by activating the ACE2/Ang-(1-7)/Mas receptor signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Priyavathi Sureshkumar, Robson Augusto Souza dos Santos, Natalia Alenina, Stefan Mergler, Michael Bader
Summary: The G protein-coupled receptor MAS is the receptor for the endogenous ligand Angiotensin (Ang)-(1-7). This paper demonstrates the importance of MAS signaling in developing novel therapeutics for cardiovascular diseases. Ang-(1-7) induces calcium influx in MAS-transfected HEK293 cells, which is dependent on plasma membrane Ca2+ channels, phospholipase C, and protein kinase C. The study also reveals that MAS utilizes non-selective transient receptor potential channels (TRPs) for calcium entry.
Article
Engineering, Biomedical
Marinus A. Wesdorp, Andrea Schwab, Ezgi Irem Bektas, Roberto Narcisi, David Eglin, Martin J. Stoddart, Gerjo J. V. M. Van Osch, Matteo D'Este
Summary: This study presents an in vitro culture model that describes the important functions of neutrophils in tissue repair. The response of neutrophils to different biomaterials was investigated, and differences in neutrophil survival, oxidative burst, myeloperoxidase and neutrophil elastase expression, and cytokine secretion were observed.
BIOACTIVE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Virendra Tiwari, Jitendra Singh, Priya Tiwari, Swati Chaturvedi, Shivangi Gupta, Akanksha Mishra, Sonu Singh, Muhammad Wahajuddin, Kashif Hanif, Shubha Shukla
Summary: In this study, the role of the ACE2/Ang-(1-7)/Mas receptor axis in Alzheimer's disease (AD) was investigated using various methods. The results showed that activation of this axis could improve cognitive impairment and amyloid deposition in an AD-like rat model. These findings suggest the potential involvement of the ACE2/Ang-(1-7)/Mas axis in the pathophysiology of AD by regulating inflammation and cognitive functions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lu Wang, Wu Lei, Shuijuan Zhang, Li Yao
Summary: MCC950 is a potent inhibitor of NLRP3 inflammasome with the ability to effectively suppress LPS-induced lung inflammation in mice by reducing inflammatory cell accumulation, pathological progression, and cytokine expression. These findings suggest potential clinical translation for the treatment of ARDS/COPD.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Immunology
Zhongjie Wang, Wenhan Huang, Feifeng Ren, Lei Luo, Jun Zhou, Dongmei Huang, Mei Jiang, Huaan Du, Jinqi Fan, Lin Tang
Summary: The study demonstrated that Ang-(1-7) and AVE0991 can reduce inflammatory cytokine levels, inhibit joint inflammation and bone destruction, as well as alleviate myocardial interstitial fibrosis. Ang-(1-7) may mediate these effects through the Mas receptor.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Bruno Garcia, Fuhong Su, Francesca Manicone, Laurence Dewachter, Raphael Favory, Amina Khaldi, Alexander Moiroux-Sahroui, Anthony Moreau, Antoine Herpain, Jean-Louis Vincent, Jacques Creteur, Fabio Silvio Taccone, Filippo Annoni
Summary: The aim of this study was to investigate the effects of Ang-(1-7) infusion on the development and severity of septic shock. The results showed that early Ang-(1-7) infusion can prevent the development of septic shock, reduce norepinephrine requirements, limit the increase of interleukin-6 levels, and prevent renal dysfunction.
Article
Immunology
Shuai Mao, Jian Lv, Meng Chen, Ningning Guo, Yu Fang, Jingjing Tong, Xianghu He, Gang Wu, Zhihua Wang
Summary: The expression of Serinc2 is upregulated in acute lung injury caused by cecal ligation and puncture. Knockout of Serinc2 worsens lung injury in mice induced by cecal ligation and puncture. Serinc2 deficiency leads to increased expression of inflammatory factors and over-activation of multiple signaling pathways. On the other hand, overexpression of Serinc2 in RAW264.7 cells can suppress the inflammatory response induced by lipopolysaccharide and alleviate cell apoptosis.
JOURNAL OF INFLAMMATION-LONDON
(2022)
Article
Cell Biology
Xiaojie Wang, Liang Wang, Mingyi Luo, Qian Bu, Chunqi Liu, Linhong Jiang, Rui Xu, Shaomin Wang, Haoluo Zhang, Jiamei Zhang, Xuemei Wan, Hongchun Li, Yonghai Wang, Bin Liu, Ying Zhao, Yuanyuan Chen, Yanping Dai, Min Li, Hongbo Wang, Jingwei Tian, Yinglan Zhao, Xiaobo Cen
Summary: Clarithromycin (CLA) treatment causes anxiety-like behaviors, possibly through altered glycerophospholipid metabolism.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Neurosciences
Yonghai Wang, Hongchun Li, Ying Zhao, Feng Qin, Liang Wang, Linhong Jiang, Xiaojie Wang, Rong Chen, Yuman He, Qinfan Wei, Shu Li, Yuanyuan Chen, Yuzhou Xiao, Yanping Dai, Qian Bu, Yinglan Zhao, Jingwei Tian, Hongbo Wang, Xiaobo Cen
Summary: Sevoflurane exposure in the neonatal period causes cognitive impairment and social behavior deficits in adolescent rats. Lipidomics and proteomics analysis revealed the remodeling of lipid metabolism and downregulation of LPCAT1 expression in the hippocampus, suggesting their involvement in neurobehavioral dysfunction.
Article
Chemistry, Multidisciplinary
Yan-ni Wang, Zhi-hao Zhang, Hong-jiao Liu, Zhi-yuan Guo, Liang Zou, Ya-mei Zhang, Ying-yong Zhao
Summary: Dysregulation in lipid metabolism is closely related to the pathogenesis of chronic kidney disease (CKD). This study identified differential plasma lipid species in CKD rats and revealed that dysregulation of PC metabolism was involved in CKD pathology. Moreover, administration of Rheum officinale improved kidney function and aberrant PC metabolism in CKD rats.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Cell Biology
Zhuang Qian, Zhen Liu, Zhenhua Feng, Zhenning Cai, Yong Qiu, Zezhang Zhu
Summary: Emerging evidence suggests that the circadian clock gene Rev-erb alpha plays a role in cartilage metabolism, but its contribution to growth plate chondrogenesis remains unclear. In this study, it was found that inhibiting Rev-erb alpha suppressed longitudinal bone elongation and disrupted growth plate development. Mechanistically, knock-down of Rev-erb alpha up-regulated the MAPK-ERK1/2 pathway in chondrocytes. However, inhibition of this pathway partially alleviated the effects of Rev-erb alpha inhibition on bone elongation and growth plate development. These findings provide evidence for the important role of Rev-erb alpha in growth plate chondrogenesis.
Article
Engineering, Chemical
Mengxiang Ye, Chao Zhang, Zhenzhen Liu, Huaimeng Li, Zhen Fu, Haimin Zhang, Guozhong Wang, Yunxia Zhang
Summary: The conversion of e-waste into high-performance catalysts offers an economical solution for the degradation of bisphenol A (BPA). In this study, CuAu bimetallic catalysts were electro-codeposited on carbon cloth (CC) with waste central processing unit (CPU) leachate as the electrolyte. The resulting CuAu/CC composites were efficient electro-catalysts for the decontamination of BPA via the electro-Fenton process. The optimized CuAu/CC electrodes achieved 99.5% BPA removal and 64.2% total organic carbon (TOC) removal within 120 minutes.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Oncology
Shuchen Chen, Wanyi Huang, Zhenzhen Liu, Meizi Jin, Jielin Li, Lihui Meng, Ting Li, Yuzhu Diao, Hong Gao, Chengyu Hong, Jian Zheng, Fei Li, Yue Zhang, Dan Bi, Lin Teng, Xiaoling Li
Summary: This study identifies nine mutant genes and smoking history associated with organ tropism metastases of NSCLC and provides three models for predicting metastatic organs.
Article
Environmental Sciences
Chunhong Teng, Ying Li, Tao Cang, Hao Xu, Zhenzhen Liu, Peipei Qi, Zhiwei Wang, Huiyu Zhao, Shanshan Di, Xinquan Wang
Summary: This study investigated the enantioselective bioaccumulation and dissipation of uniconazole enantiomers in an earthworm-soil microcosm. A fast enantioseparation method was established using supercritical fluid chromatography-tandem mass spectrometry. The results showed that the bioaccumulation of uniconazole enantiomers in earthworms increased with time and reached a maximum on the 7th day, while the dissipation in soil was slow. No enantioselectivity was observed in the earthworm-soil microcosm.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Immunology
Siwei Wang, Yanhua Zhou, Jiangrong Huang, Huilin Li, Huidan Pang, Dandan Niu, Guangyao Li, Fei Wang, Zushan Zhou, Zhenzhen Liu
Summary: This review provides an overview of the establishment, pathological features, potential mechanisms, advantages, and limitations of currently available rheumatoid arthritis (RA) models. It highlights the importance of translating laboratory research into clinical practice.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Chemistry, Applied
Zhenzhen Liu, Huiyu Zhao, Jiao Wang, Zhiwei Wang, Shanshan Di, Hao Xu, Qiang Wang, Xinhong Wang, Xinquan Wang, Peipei Qi
Summary: A sample pretreatment method based on magnetic dispersive solid-phase extraction was developed for the analysis of multi-class antibiotics in aquatic products. By optimizing the extraction and purification procedure, the simultaneous extraction of multiple antibiotics was achieved using acetonitrile-2% acetic acid. The use of amphiphilic magnetic particles and C18 as adsorbents effectively removed matrix interferences, resulting in significantly reduced matrix effects of analytes. The method showed satisfactory linearity, recovery, precision, and sensitivity under the optimized conditions, with limits of quantification ranging from 0.25 to 0.5 µg/kg. Additionally, the method demonstrated advantages in terms of operation convenience and efficiency due to the use of magnetic particles. It was successfully applied to analyze antibiotic residues in freshwater and seafood products, highlighting its suitability for antibiotic residues analysis in aquatic products.
Article
Environmental Sciences
Zhendong Liu, Wenhu Qv, Haolin Cai, Hongliang Guan, Shuaizhe Zhang
Summary: In this paper, an efficient and robust hybrid SfM method is proposed to address the challenges of loose spatial distribution of images within subclusters and unbalanced connectivity between subclusters. The method employs a multifactor joint scene partition measure and a preassignment balanced image expansion algorithm to improve the degree of connection among subclusters. Experimental results demonstrate that the proposed method outperforms state-of-the-art methods in terms of accuracy and robustness.
Article
Green & Sustainable Science & Technology
Bin Luo, Zhenhai Liu, Sichao Mai
Summary: Since the 1960s, scholars have conducted empirical research on environmental federalism theory, mainly focusing on whether a country's environmental regulation should be centralized or decentralized. Countries have been actively exploring and implementing their own environmental governance systems, especially in the face of resource constraints, environmental challenges, and the need for sustainable development. Encouraging enterprises' technological innovation to build an appropriate environmental governance system and promote green development is an urgent practical problem to be solved.
Article
Agronomy
Ming Li, Qingfen Zhang, Shiyu Wei, Zhendong Liu, Rui Zong, Tuo Jin, Mingming Zhang, Chitao Sun, Quanqi Li
Summary: The cumulative effects of biodegradable film mulch on soil quality were investigated in the study. It was found that both black and transparent biodegradable film mulching reduced soil bulk density, increased soil microbial and enzyme activity, but did not significantly affect soil nutrient content. Black biodegradable film mulching showed the highest increase in soil quality index and significantly improved summer maize grain yield.
ARCHIVES OF AGRONOMY AND SOIL SCIENCE
(2023)
Review
Infectious Diseases
Yanchun Zhong, Yuxi Huang, Di Zhang, Zhaoyuan Chen, Zhenxing Liu, Yongjun Ye
Summary: This article reports a rare case of isolated sacral cryptococcal osteomyelitis in an immunocompetent patient. Furthermore, it identified and reviewed 18 published cases of spine cryptococcal osteomyelitis. Clinical manifestation and imaging are insufficient to diagnose cryptococcal osteomyelitis of the spine, and invasive examinations, such as puncture biopsy and fungal examinations, are needed. Antifungal therapy yields satisfactory results for the treatment of cryptococcal osteomyelitis of the spine, however, if the infective lesion is large, especially when it compresses the spinal cord and nerves, a regimen combining aggressive surgery with antifungal therapy is indispensable.
BMC INFECTIOUS DISEASES
(2023)
Article
Chemistry, Multidisciplinary
Zhendong Liu, Sainan Liu, Bin Liu, Yulong Bian, Meng Yuan, Chunzheng Yang, Qi Meng, Changxiao Chen, Ping'an Ma, Jun Lin
Summary: This study developed a simple one-step strategy to construct Fe3+-naphthazarin metal-phenolic networks (FNP MPNs) with ultrahigh loading capacity. The FNP MPNs can be triggered by acid and GSH to release naphthazarin and Fe3+, which is further reduced to Fe2+ to produce hydroxyl radicals. The FNP MPNs also have MRI functionality and can effectively deplete GSH, disrupt intracellular redox homeostasis, and enhance CDT effects.
Article
Biochemistry & Molecular Biology
Yan-Ni Wang, Hua Miao, Xiao-Yong Yu, Yan Guo, Wei Su, Fei Liu, Gang Cao, Ying-Yong Zhao
Summary: Patients with membranous nephropathy (MN) are diagnosed by the presence of phospholipase A2 receptor (PLA2R) before they progress to renal failure. The aryl hydrocarbon receptor (AHR), NF-kB, and Nrf2 pathways are involved in the pathogenesis and progression of chronic kidney disease. This study investigated the effect of AHR signalling on the NF-kB and Nrf2 pathways in MN patients, rats, and podocytes.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
