Journal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume 10, Issue 12, Pages 7897-7905Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2010.3012
Keywords
Arginine-Rich; Cell-Penetrating Peptide; Cellular Internalization; Protein Transduction Domain; Quantum Dot
Categories
Funding
- National Institute of Biomedical Imaging and Bioengineering [R15EB009530]
- National Science Council of Taiwan [NSC 97-2621-B-259-003-MY3]
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Quantum dots (QDs) are luminescent semiconductor nanocrystals that are widely used as fluorescent probes in biomedical applications, including cellular imaging and tumor tracking. Cell-penetrating peptides (CPPs), also called protein transduction domains (PTDs), are short basic peptides that permeate cell membranes and are able to deliver a variety of macromolecule cargoes, such as DNAs, RNAs, proteins, and nanomaterials. Here we review strategies to couple QDs to CPPs, by either covalent linkages or noncovalent interactions, to provide a tool to study intracellular delivery. This facilitated transport of QDs by CPPs into cells is both simple and efficient. Accordingly, CPP-QD nanoparticles are likely to be of broad utility in biological research and advance the development of medical and pharmaceutical therapeutics.
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