Article
Engineering, Biomedical
Liming Zheng, Zaikai Zhuang, Yixuan Li, Tianshu Shi, Kai Fu, Wenjin Yan, Lei Zhang, Peng Wang, Lan Li, Qing Jiang
Summary: This study demonstrates that iron oxide nanoparticles (IONPs) can alleviate estrogen deficiency-induced osteoporosis by regulating local immunity in bone tissues. IONPs scavenge reactive oxygen species and promote osteogenic differentiation while inhibiting osteoclast differentiation. Additionally, the use of alendronate to deliver IONPs to bone tissues enhances therapeutic efficacy. The bone targeting ability, therapeutic efficiency, and biocompatibility of this novel bone targeting iron oxide is verified in ovariectomy-induced osteoporotic mice.
BIOACTIVE MATERIALS
(2022)
Review
Oncology
Muhammed H. Elnaggar, Abdelrahman I. Abushouk, Ahmed H. E. Hassan, Hadeer M. Lamloum, Amira Benmelouka, Shurouk A. Moatamed, Hossam Abd-Elmegeed, Somia Attia, Aya Samir, Nouran Amr, Dina Johar, Samy Zaky
Summary: The use of nanoparticles as targeted carriers for chemotherapy in hepatocellular carcinoma has shown promising results, with active targeting being the most commonly researched method. However, clinical research still faces challenges such as batch variations, production limitations, and lack of toxicity data.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xiaoyu Wang, Qing Ma, Chaochao Wen, Tao Gong, Jing Li, Wenting Liang, Meining Li, Yuyao Wang, Rui Guo
Summary: The novel nano-drug carrier constructed in this study showed good stability and blood compatibility, successfully loaded a hydrophobic anti-cancer drug, and demonstrated excellent liver cancer targeting therapy efficacy.
Article
Chemistry, Multidisciplinary
Jifa Liu, Xinglong Shi, Yangcui Qu, Guannan Wang
Summary: This study presents a novel biomimetic nanoparticle platform (ZnMnFe2O4-PEG-FA) that enables combined photothermal therapy and nanozyme-catalyzed therapy. These nanoparticles exhibit excellent photothermal effect and catalytic ability, alleviating the limitations of conventional treatments. Furthermore, they also have imaging capabilities for monitoring and guiding cancer treatment.
Article
Nanoscience & Nanotechnology
Xiaoming Yang, Jianmin Xiao, Lingyu Jiang, Lang Ran, Yangyang Fan, Minghui Zhang, Yuxue Xu, Cuifang Yao, Baijiao An, Yang Yang, Chunhua Yang, Geng Tian, Guilong Zhang, Yin Zhang
Summary: This study synthesized a novel nanoparticle (VIO) with chemodynamic, photothermal, and diagnostic capacities, enhancing the tumor suppression effect by increasing reactive oxygen species (ROS) and inducing apoptosis and ferroptosis. It showed potential in inhibiting hepatocellular carcinoma and angiogenesis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Svea Becker, Jeffrey Momoh, Ilaria Biancacci, Diana Moeckel, Qingbi Wang, Jan-Niklas May, Huan Su, Lena Susanna Candels, Marie-Luise Berres, Fabian Kiessling, Maximilian Hatting, Twan Lammers, Christian Trautwein
Summary: Fasting has a positive impact on tumor microenvironment and drug delivery, with intermittent fasting slowing down tumor growth and improving liposome delivery. Fasting also promotes tumor cell uptake of liposomes. Combining fasting with liposomal doxorubicin treatment increases antitumor efficacy and reduces systemic side effects.
Article
Biotechnology & Applied Microbiology
Nam H. B. Tran, Diem D. N. Nguyen, Ngoc Mai Nguyen, Chau Tran, Ngoc Thanh Nguyen Thi, Duyen T. K. Ho, Hoai-Nghia Nguyen, Lan N. Tu
Summary: The authors examined whether displaying multiple homing peptides on exosomes could enhance tumor targeting efficiency. Exosomes from HEK293F cells were engineered to display either single or dual tumor-penetrating peptides, iRGD and tLyp1. Results showed that dual iRGD-tLyp1 exosomes loaded with doxorubicin (Dox) significantly improved Dox uptake in breast cancer cell lines MCF-7 and MDA-MB-231, outperforming single iRGD or tLyp1 exosomes. The dual iRGD-tLyp1 exosomal Dox also exhibited the highest potency, with IC50/GI(50) values 3.7-17.0 times lower than free Dox and other exosomal Dox. Therefore, selecting appropriate combinations of homing peptides could be a promising strategy for precision nanomedicine.
Article
Engineering, Biomedical
Dawei Ni, Beibei Guo, Zhangyan Zhong, Yu Chen, Guang Yang, Jiangtao Yang, Zhiyuan Zhong, Fenghua Meng
Summary: This paper studies the influence of disulfide crosslinking on actively targeted nanomedicines for tumor therapy and finds that micellar docetaxel with a high disulfide content is advantageous in terms of stability, tumor uptake, and therapeutic efficacy.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Yalan Tu, Rui Zheng, Fangzhou Yu, Xuan Xiao, Maoling Jiang, Youyong Yuan
Summary: The study developed a dual-drug delivery system that can deliver two anticancer drugs with a flexible and controllable drug release ratio, achieving predetermined drug release ratios for synergistic anticancer therapy. This provides a simple and efficient strategy for combination chemotherapy.
SCIENCE CHINA-CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Chiseon Ryu, Hwangjae Lee, Hohyeon Kim, Seong Hwang, Yaser Hadadian, Ayeskanta Mohanty, In-Kyu Park, Beongki Cho, Jungwon Yoon, Jae Young Lee
Summary: We synthesized magnetic IONP/polymer nanocomposites (MNCs) by embedding IONPs in a poly(L-lactic acid) (PLA) matrix via nanoemulsion. The MNCs showed enhanced heating efficiency with over two-fold increase compared to nonembedded bare IONPs. In addition, the MNCs exhibited good colloidal stability under physiological conditions and maintained their heating efficiency during 48 h of incubation in cell culture medium.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Ting He, Jin He, Muhammad Rizwan Younis, Nicholas Thomas Blum, Shan Lei, Yinling Zhang, Peng Huang, Jing Lin
Summary: The study developed a pH/light dual-stimuli-responsive nanotheranostic agent for effective treatment of U87MG tumors in vivo, showing potential for application in multimodal imaging-guided synergistic therapy of cancer.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Didem Ag Seleci, Viktor Maurer, Firat Baris Barlas, Julian Cedric Porsiel, Bilal Temel, Elcin Ceylan, Suna Timur, Frank Stahl, Thomas Scheper, Georg Garnweitner
Summary: This study developed transferrin-decorated niosomes containing integrated magnetic iron oxide nanoparticles and quantum dots for efficient imaging of glioma, with support from magnetic and active targeting. Flow cytometry and in vitro imaging studies confirmed the potential application of this system in dual-targeted imaging of glioma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Liuwei Zhang, Ming Qian, Hongyan Cui, Shuang Zeng, Jingyun Wang, Qixian Chen
Summary: The study developed dual prodrug nanomedicine that can sequentially respond to intracellular chemical potentials, overcoming predefined biological barriers and facilitating intracellular trafficking. The nanomedicine showed significant cytotoxic potencies due to its ability to be activated and liberated in the cytoplasm, leading to potent tumor suppression efficacy in treating solid breast adenocarcinoma.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Nayer Sultana, Allan E. David
Summary: Silica nanoparticles functionalized with hyaluronic acid (HA) and folic acid (FA) were developed for dual-ligand targeting of CD44 and folate receptors in colon cancer. The nanoparticles showed good biocompatibility and high cell viability. The study demonstrated the potential of these targeted nanoparticles as promising candidates for delivering therapeutic agents. Ongoing research will evaluate the therapeutic efficacy of these nanoparticles using in vitro and in vivo cancer models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Huai-An Chen, Yu-Jen Lu, Banendu Sunder Dash, Yin-Kai Chao, Jyh-Ping Chen
Summary: Combination chemo-photothermal therapy using HA/PMNPc nanoparticles can effectively treat cancer by reducing the dose of chemotherapeutic drugs and inducing cell death through heat generation. The nanoparticles exhibit targeted delivery, pH-sensitive drug release, and hyperthermia effects, resulting in higher cytotoxicity and apoptosis in cancer cells. In vivo studies demonstrate that the treatment modality inhibits tumor growth and increases survival time in mice.
Article
Nanoscience & Nanotechnology
Xiao Huang, Juan Lu, Danyang Yue, Yijuan Fan, Caixia Yi, Xiaoying Wang, Mengxue Zhang, Jun Pan
Review
Pharmacology & Pharmacy
Xiao Huang, Xi Zheng, Zuojuan Xu, Caixia Yi
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2017)
Article
Chemistry, Multidisciplinary
Xiao Huang, Xiaoying Wang, Sichun Wang, Jiawen Yang, Li Zhong, Jun Pan
Meeting Abstract
Pharmacology & Pharmacy
X. Huang, Y. J. Xu, L. C. Yang, J. Q. Wu, X. Zheng, J. Fei
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2017)