Article
Pharmacology & Pharmacy
Zhiwei Zhang, Lixin Ma, Jingwen Luo
Summary: The development of chondroitin sulfate liposomes (CSLs) for the co-delivery of retinoic acid (RA) and doxorubicin (DOX) shows promising results in suppressing lung metastasis of breast cancer. CSLs efficiently encapsulate both RA and DOX and demonstrate better anticancer and anti-metastatic activity compared to other drug carriers.
Article
Chemistry, Applied
Zijuan Yu, Dawei Yu, Junli Dong, Wenshui Xia
Summary: This study investigated the polyelectrolyte complexation between chitosan and chondroitin sulfate, as well as the ultrasonication assistance, for the encapsulation of proanthocyanidin in nanoparticles. The optimal conditions for the preparation of nanoparticles were determined to be 1.5 mg/mL of chitosan and chondroitin sulfate, a 1:3 wt ratio of chitosan/chondroitin sulfate, 0.5 mg/mL of proanthocyanidin, pH 3.25, and 1 min of ultrasonic treatment. The resulting nanoparticles had a small size of approximately 300 nm and high entrapment efficiency of 37.5%. The incorporation of proanthocyanidin-encapsulated nanoparticles into chitosan bio-films decreased the bacterial count and lipid oxidation of stored fillets, demonstrating their potential application in food preservation.
FOOD HYDROCOLLOIDS
(2022)
Article
Biophysics
Naghmeh Akbari Moghadam, Fatemeh Bagheri, Mohamadreza Baghaban Eslaminejad
Summary: Chitosan-chondroitin sulfate nanoparticles have been synthesized as a platform for efficient gene sequence delivery, showing potential for gene therapy in cartilage diseases.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Materials Science, Characterization & Testing
Meixin Li, Lei Xu, Fenbo Ma, Bin Tang, Chenghe Qin
Summary: Researchers have synthesized a biofunctional composite combining carboxymethyl-chitosan and strontium chondroitin sulfate for bone regeneration. The composites showed porous structures, good swelling capacity, and the ability to promote osteogenic activity and suppress inflammatory responses. These findings suggest that the developed composites have potential as skeletal candidates for regenerative engineering applications.
Article
Chemistry, Applied
Lei Xu, Fenbo Ma, Frankie K. L. Leung, Chenghe Qin, William W. Lu, Bin Tang
Summary: Bone defects caused by trauma are increasingly common in aged populations, and repairing bone defects in the elderly remains challenging due to decreased bone healing capacity compared to young adults. Developing effective biomaterials targeted at bone defects in the elderly is crucial for bone-tissue engineering strategies, and more attention is needed for bone regeneration in the elderly.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Lumin Yang, Haofei Huang, Huajing Zeng, Xiaoduo Zhao, Rui Wang, Zhengfeng Ma, Zengjie Fan, Yong-min Liang, Shuanhong Ma, Feng Zhou
Summary: Rheumatoid arthritis (RA) is a chronic inflammatory immune and lubrication dysfunction disease that causes great damage to the joints. A novel polysaccharide nanoparticle lubricant, chitosan nanoparticles (CS NPs) grafting chondroitin sulfate (CS-CHI), is synthesized to improve the lubricity of nanoparticles. The CS-CHI NPs also have effective loading and sustained drug release ability for anti-inflammatory drug diclofenac sodium (DS), along with good biocompatibility. In vitro animal experimental results indicate that the CS-CHI@DS NPs have inhibitory effects on inflammatory factors and can effectively prevent further destruction of damaged cartilage.
CARBOHYDRATE POLYMERS
(2023)
Article
Biotechnology & Applied Microbiology
Sandra Escalante, Gustavo Rico, Jose Becerra, Julio San Roman, Blanca Vazquez-Lasa, Maria Rosa Aguilar, Ivan Duran, Luis Garcia-Fernandez
Summary: Articular cartilage is an important avascular tissue that provides support, shock absorption, and facilitates joint motion. Current surgical treatments for cartilage damage have limitations in restoring fully functional cartilage. This study presents the development of hydrogels based on hyaluronic acid and chitosan loaded with chondroitin sulfate, which have the potential to improve the microfracture procedure and promote the colonization of articular cartilage by chondrocytes. These hydrogels act as delivery systems for chondroitin sulfate and have mucoadhesive properties, making them promising for next-generation therapies against articular cartilage damage.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Gulshakhar Kudaibergen, Madina Zhunussova, Ellina A. Mun, Anar Arinova, Vyacheslav Ogay
Summary: This study focused on synthesizing cryogels based on gelatin, chitosan, and chondroitin sulfate, and investigating the impact of chondroitin sulfate on the physicochemical properties of the cryogels, as well as confirming their non-toxicity to stem cells.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Joanna Klara, Adrianna Marczak, Anna Latkiewicz, Wojciech Horak, Joanna Lewandowska-Lancucka
Summary: This study presents a novel injectable hydrogel composed of collagen, chitosan, and lysine-functionalized chondroitin sulfate. The physicochemical and biological properties of the hydrogels can be adjusted by varying the concentrations of the components. The addition of lysine moieties to chondroitin sulfate enhances the bioactivity of the hydrogels and promotes cell proliferation and adhesion. These hydrogels have great potential for tissue engineering applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Magdalena Wytrwal, Katarzyna Szmajnta, Miroslaw Kucharski, Jakub Nowak, Ewa Oclon, Mariusz Kepczynski
Summary: Loss of cartilage is a common clinical problem. This study focused on using a small molecule called Kartogenin (KGN) embedded in liposomes to protect or repair cartilage. The researchers found that hydrophobically modified chondroitin sulfate (CS) derivatives can interact with the liposome membrane and enhance the chondrogenic properties of the KGN-loaded liposomes. The cytotoxicity of the CS derivatives was reduced when the CS was alkylated, and the higher substituted CS formed stable nanoaggregates on the liposome surface, eliminating the overall cytotoxicity. However, the expression levels of chondrogenic markers were enhanced for the KGN-loaded liposomes coated with lower substituted CS, and the formulation had a decreased hypertrophy effect compared to the pure polymeric derivative.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Yuan Guan, Yue Ning, Zhengming Xu, Chuang Zhou, Zhengang Zhao
Summary: In this study, nanoliposomes with different layers were successfully prepared for betanin encapsulation. The double-layer-modified nanoliposomes demonstrated improved stability and slower release compared to other formulations. This research provides a new approach to enhance the stability and bioavailability of betanin.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Polymer Science
Shumin Wang, Xiaoguo Ji, Shumin Chen, Chunyue Zhang, Yibing Wang, Haodong Lin, Liming Zhao
Summary: A novel hemostatic dressing, Me-CMC/CSS, developed using thiol-ene click chemistry, showed rapid water absorption and transformation into soft hydrogels for wound sealing. The dressing achieved good hemostasis with significantly reduced blood clotting index and total blood loss in a rat liver hemorrhage model compared to untreated or gelatin sponge-treated groups. The excellent platelet adhesion ability of Me-CMC/CSS dressing suggests its potential application as a rapid hemostatic material.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Zafina Budhwani, Jenna T. Buragina, Jen Lang, Jeella Z. Acedo
Summary: The rise of drug-resistant bacteria poses a major threat to public health, and there is an urgent need for new antimicrobial compounds and treatments. In this study, a novel bacteriocin called bawcin was identified and characterized, showing broad-spectrum activity against Gram-positive bacteria. It has potential applications as an antibiotic and natural preservative in the food and livestock industries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Swati Sharma, Harishkumar Madhyastha, Shrikant Sitaram Kirwale, Kentaro Sakai, Yash T. Katakia, Syamantak Majumder, Aniruddha Roy
Summary: This study developed a unique wound scaffold material (CH-CS PEC) with excellent antibacterial and anti-inflammatory properties. The results showed that CH-CS PEC could promote wound healing in infected wounds by inducing bacterial cell death and modulating macrophage function.
CARBOHYDRATE POLYMERS
(2022)
Article
Materials Science, Multidisciplinary
Dan Zou, Jingan Li, Fang Kou, Xiao Luo, Ping Yang
Summary: This study compares the effects of CS A and CS C on cardiovascular implant surfaces through preparing functionalized coatings. The results show that the PDA/HD-CS C coating exhibits better control over the phenotype and distribution of macrophages, smooth muscle cells, and endothelial cells.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Article
Biophysics
Yasmine Miguel Serafini Micheletto, Carlo Frederico Moro, Fernanda Cortez Lopes, Rodrigo Ligabue-Braun, Anne Helene Souza Martinelli, Carlos Manuel Marques, Andre Pierre Schroder, Celia Regina Carlini, Nadya Pesce da Silveira
COLLOIDS AND SURFACES B-BIOINTERFACES
(2016)
Article
Biophysics
Marinalva Cardoso dos Santos, Yasmine Miguel Serafini Micheletto, Nadya Pesce da Silveira, Luciano da Silva Pinto, Fernando Carlos Giacomelli, Vania Rodrigues de Lima, Tiago Elias Allievi Frizon, Alexandre Goncalves Dal-Bo
COLLOIDS AND SURFACES B-BIOINTERFACES
(2016)
Article
Chemistry, Multidisciplinary
Yasmine Miguel Serafini Micheletto, Carlos M. Marques, Nadya Pesce da Silveira, Andre P. Schroder
Article
Materials Science, Biomaterials
Illen C. Libio, Renan Demori, Marco F. Ferrao, Maria I. Z. Lionzo, Nadya P. da Silveira
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2016)
Article
Materials Science, Multidisciplinary
Yasmine Miguel Serafini Micheletto, Nadya Pesce da Silveira, Alexandre Goncalves Dal-Bo, Fernando Carlos Giacomelli, Newton Luiz Dias Filho, Tiago Elias Allievi Frizon, Carlos Manuel Marques, Andre Pierre Schroder
MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS
(2017)
Article
Food Science & Technology
Liziane D. Lacerda, Daiani C. Leite, Rosane M. D. Soares, Nadya P. da Silveira
Article
Chemistry, Multidisciplinary
Daiani C. Leite, Sergej Kakorin, Yvonne Hertle, Thomas Hellweg, Nadya P. da Silveira
Article
Biochemistry & Molecular Biology
Adriano Gennari, Francielle H. Mobayed, Brenda Da Rolt Nervis, Edilson V. Benvenutti, Sabrina Nicolodi, Nadya Pesce da Silveira, Giandra Volpato, Claucia F. Volken de Souza
Article
Pharmacology & Pharmacy
Mario Gehlen, Jose Carlos Fraga, Sergio Luis Amantea, Nadya P. Silveira, Jane Kulczynski, Eliane Roesch, Kalyana G. Portal, Paulo R. Sanches
PULMONARY PHARMACOLOGY & THERAPEUTICS
(2019)
Article
Food Science & Technology
Liziane D. Lacerda, Daiani C. Leite, Nadya P. da Silveira
JOURNAL OF CEREAL SCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Bruna Coelho de Andrade, Adriano Gennari, Gaby Renard, Brenda Da Rolt Nervis, Edilson Valmir Benvenutti, Tania Maria Haas Costa, Sabrina Nicolodi, Nadya Pesce da Silveira, Jocelei Maria Chies, Giandra Volpato, Claucia Fernanda Volken de Souza
Summary: This study synthesized iron magnetic nanoparticles functionalized with histidine and nickel for the immobilization of His-tagged recombinant enzymes, particularly beta-galactosidase. The immobilized enzyme showed increased substrate affinity and thermal stability, leading to efficient lactose hydrolysis with high recovery rates. The nanoparticles demonstrated potential applications in oriented immobilization of other high-molecular-weight enzymes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Suelen G. Trindade, Nadya P. da Silveira, Watson Loh
Summary: The aggregation behavior of the asymmetric diblock polyampholyte poly is studied in aqueous solutions, showing the formation of spherical polymer micelles with a highly hydrated core and an outer corona in a wide pH range. These aggregates display resistance to high ionic strengths, suggesting a transition from electrostatic to hydrophobic intermolecular interactions accounting for micelle formation. The persistence of the aggregates in extreme pH values or high salt concentration is attributed to remaining hydrogen bonding or hydrophobic interactions contributing to the core formation.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2021)
Article
Chemistry, Multidisciplinary
Andresa C. Ribeiro, Daiani C. Leite, Joice M. Scheibel, Rosane M. D. Soares, Nadya P. Silveira
Summary: The physicochemical properties of gliadin in different solvents and pH values were investigated, revealing that gliadin showed lower size distribution in certain conditions. The stability analysis showed that gliadin in H2O (pH 9.8) was the most stable system, while gliadin in DMSO was unstable. The techniques used in the study proved to be effective in monitoring the conformation and stability of all gliadin/solvent systems, providing valuable information for the development of new gliadin-based materials.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Nadya P. da Silveira, Roberta Zucatti, Andrielle D. Vailatti, Daiani C. Leite
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2019)
Article
Chemistry, Applied
Andresa C. Ribeiro, Angelo Rocha, Rosane M. D. Soares, Luis P. Fonseca, Nadya P. da Silveira
CARBOHYDRATE POLYMERS
(2017)
