Journal
JOURNAL OF NANOPARTICLE RESEARCH
Volume 14, Issue 2, Pages -Publisher
SPRINGER
DOI: 10.1007/s11051-012-0730-y
Keywords
SPIONs; Magnetite; Chitosan; Biotin; Blood-contacting applications; Nanobiotechnology
Categories
Funding
- Romanian Ministry of Education, Research, Youth and Sport [PN II 81051/2007 (MAGSEPDETOX)]
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Haemocompatible biotinylated superparamagnetic nanoparticles (size range 300-700 nm) have been obtained by coating magnetite through ionic gelation with a mixture of chitosan and sodium tripolyphosphate, followed by subsequent functionalisation with biotin. The evaluations of their magnetic properties together with haemocompatibility tests have shown that these nanoparticles exhibit the prerequisite behaviour for use in magnetic field-assisted separations within biological systems.
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