Article
Oncology
Nuria Lafuente-Gomez, Paula Milan-Rois, David Garcia-Soriano, Yurena Luengo, Marco Cordani, Hernan Alarcon-Iniesta, Gorka Salas, Alvaro Somoza
Summary: The study introduced a smart gemcitabine delivery system based on magnetic nanoparticles, enabling selective release in pancreatic cancer cells via disulfide bonds. The modified nanoparticles showed promising potential for biomedical applications by reducing drug toxicity in non-cancerous cells, enhancing internalization, and synergistic cytotoxic effects when combined with magnetic hyperthermia.
Article
Pharmacology & Pharmacy
Ruixue Yin, Xu Qian, Liangfa Kang, Kemin Wang, Hongbo Zhang, Shih-Mo Yang, Wenjun Zhang
Summary: The study proposed a novel strategy for regulating insulin action using insulin-conjugated magnetic nanoparticles, showing improved blood glucose control in in vivo experiments. This approach may have great potential for insulin delivery in the future.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Alexandra D. Voloshina, Elina E. Mansurova, Leysan R. Bakhtiozina, Marina M. Shulaeva, Irek R. Nizameev, Anna P. Lyubina, Syumbelya K. Amerhanova, Marsil K. Kadirov, Albina Y. Ziganshina, Vyacheslav E. Semenov, Igor S. Antipin
Summary: This study presents a redox-sensitive nanocarrier for delivering anticancer drugs, which can enhance drug penetration into cells and demonstrate selective cytotoxicity in specific cell types.
NEW JOURNAL OF CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Aziz Eftekhari, Allahveirdy Arjmand, Ayyub Asheghvatan, Helena Svajdlenkova, Ondrej Sausa, Huseyn Abiyev, Elham Ahmadian, Oleh Smutok, Rovshan Khalilov, Taras Kavetskyy, Magali Cucchiarini
Summary: Liver fibrosis is a serious condition that can lead to cirrhosis, liver cancer, and liver failure, with no effective treatment currently available. Magnetic nanoparticles show promise for the diagnosis and treatment of liver diseases, but there are still challenges to be overcome for clinical application.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Assaf Zinger
Summary: In this paper, the author presents design strategies for the two main biomimetic nanoparticles (BNP) groups: BNP composed of isolated cell membrane proteins, and BNP composed of the native cell membrane. The author also describes BNP fabrication methods and analyzes their advantages and challenges. Finally, future therapeutic applications of each BNP group are suggested and a new revolutionary concept for their use is proposed.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Nanoscience & Nanotechnology
Shruthi Polla Ravi, Yasmeen Shamiya, Aishik Chakraborty, Ali Coyle, Alap Ali Zahid, Jin Wang, Michael S. H. Boutilier, Emmanuel A. Ho, Arghya Paul
Summary: In this study, a biomimetic cell-derived nanoparticle (CDN) loaded with Dexamethasone was developed, which showed efficient cellular uptake and stem cell differentiation. These CDNs exhibited good cytocompatibility and stability, making them suitable for bone regeneration applications.
ACS APPLIED NANO MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Anas Ahmad, Mohammad Imran, Nisha Sharma
Summary: The assessment of human and environmental risks of nanoparticulate material is crucial and requires the development of scientific tools and techniques. Challenges exist in toxicology assessment and regulatory guidance for nanocarriers. Nanotoxicology plays a significant role in pharmaceutical drug development and commercialization potential.
Review
Polymer Science
Azeez Yusuf, Awatif Rashed Z. Almotairy, Hanan Henidi, Ohoud Y. Alshehri, Mohammed S. Aldughaim
Summary: Nanotechnology has experienced rapid development in the past four decades and has revolutionized various aspects of everyday life. It has had significant impacts on fields like medicine and food industry, leading to improvements in shelf life of food, drug delivery, and development of specific therapeutics.
Review
Chemistry, Multidisciplinary
Yun Liu, Guangze Yang, Yue Hui, Supun Ranaweera, Chun-Xia Zhao
Summary: Nanoparticles (NPs) have gained significant interest in drug delivery, and microfluidics shows promise in their precise control and manufacturing. The successful use of microfluidic NPs in mRNA vaccines represents a major milestone and demonstrates the feasibility of industrial-scale production. This article provides a critical review of recent progress in microfluidic NPs for drug delivery, including the synthesis of organic and inorganic NPs, and their various applications.
Article
Chemistry, Multidisciplinary
Yaxuan Zhao, Kai Feng, Guojun Lei, Jingjing Shen, Yang Liu, Yiling Ruan, Xiaolian Sun
Summary: This study constructs a nanosystem for the sequential release of TRAIL and GOx to achieve synergistic cancer treatment. The nanosystem can quickly release TRAIL to induce tumor cell apoptosis and enhance the cellular uptake of the cores. It can also release GOx to trigger a cascade reaction to generate free radicals for tumor inhibition. Experimental results demonstrate the separate delivery of TRAIL and GOx and their remarkable synergistic anti-cancer effect.
Review
Pharmacology & Pharmacy
Hannah C. Zierden, Rachel L. Shapiro, Kevin DeLong, Davell M. Carter, Laura M. Ensign
Summary: Preterm birth is defined as delivery before 37 weeks of gestation, with 15 million infants born prematurely globally each year, increasing the risk of mortality and health challenges. While the only FDA approved therapy for preventing preterm birth in the U.S. has faced recent setbacks, interdisciplinary efforts are underway to develop next generation therapies to prevent preterm birth and save infant lives. This research aims to better identify women at risk for preterm birth, prevent premature labor, and ultimately improve outcomes for newborns.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Chemistry, Physical
Jonas Dinter, Ralf. P. P. Friedrich, Hai Yang, Christian Pilarsky, Harald Mangge, Marina Poettler, Christina Janko, Christoph Alexiou, Stefan Lyer
Summary: Pancreatic ductal adenocarcinoma is a difficult-to-treat cancer with poor long-term survival rates. In this study, a 3D cell culture model of human pancreatic ductal adenocarcinoma was used to investigate the potential use of superparamagnetic iron oxide nanoparticles (SPIONs) as a drug delivery system for the chemotherapeutic agent mitoxantrone (MTO). The results showed that MTO-loaded SPIONs induced cell death in tumor spheroids, with increased uptake in spheroids with a SMAD4 mutation. This suggests that MTO-loaded SPIONs could be a promising approach for treating pancreatic ductal adenocarcinomas.
Review
Pharmacology & Pharmacy
Fangyu Yang, Jianjiang Xue, Guixue Wang, Qizhi Diao
Summary: Cardiovascular disease is a common health problem worldwide, and current pharmaceutical treatment is suboptimal. Nanoparticle-based drug delivery systems have shown significant therapeutic effects and offer a safer and more effective strategy for the treatment of cardiovascular diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Mingyue Cui, Christian Wiraja, Sharon Wan Ting Chew, Chenjie Xu
Summary: Topical drug delivery has advantages over other routes, but the stratum corneum poses a challenge. Nanotechnology offers opportunities to overcome this challenge with nanocarriers like liposomes and nanoparticles. These formulations show potential in treating skin disorders, with further developments needed.
MOLECULAR PHARMACEUTICS
(2021)
Review
Transplantation
Gianmarco Sabiu, Vivek Kasinath, Sungwook Jung, Xiaofei Li, George C. Tsokos, Reza Abdi
Summary: Kidney diseases are a significant global health problem with limited treatment options. Nanomedicines, as novel drug-delivery systems, show great promise in the treatment of kidney diseases. However, there are limitations hindering their clinical application.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Chemistry, Medicinal
Ozge Uyaroglu, Hasan Demiroglu, Gokcen Topal, Yasemin Parlak, Fikriye Gul Gumuser, Elgin Uluer Turkoz, Volkan Demir, Buket Ates, Perihan Unak, Ugur Avcibasi
MEDICINAL CHEMISTRY RESEARCH
(2017)
Article
Chemistry, Inorganic & Nuclear
Ayse Karaoglu, Pedro Arce, Diego Obradors, Juan I. Lagares, Perihan Unak
APPLIED RADIATION AND ISOTOPES
(2018)
Article
Chemistry, Analytical
Ugur Avcibasi, Hasan Demiroglu, Serhan Sakarya, Perihan Unak, Volkan Tekin, Buket Ates
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2018)
Article
Veterinary Sciences
Hasan Demiroglu, Gokcen Topal, Yasemin Parlak, Fikriye Gul Gumuser, Elgin Uluer Turkoz, Volkan Tekin, Buket Ates, Perihan Unak, Ugur Avcibasi
KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI
(2018)
Article
Nanoscience & Nanotechnology
Adam J. Watkins, Gillian Pearce, Perihan Unak, Ozge K. Guldu, Volkan Yasakci, Oguz Akin, Omer Aras, Julian Wong, Xianghong Ma
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2018)
Article
Multidisciplinary Sciences
Omer Aras, Gillian Pearce, Adam J. Watkins, Fuad Nurili, Emin Ilker Medine, Ozge Kozgus Guldu, Volkan Tekin, Julian Wong, Xianghong Ma, Richard Ting, Perihan Unak, Oguz Akin
Article
Chemistry, Analytical
Volkan Yasakci, Volkan Tekin, Ozge Kozgus Guldu, Vedat Evren, Perihan Unak
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2018)
Article
Chemistry, Applied
Perihan Unak, Volkan Tekin, Ozge Kozgus Guldu, Omer Aras
APPLIED ORGANOMETALLIC CHEMISTRY
(2020)
Article
Chemistry, Inorganic & Nuclear
Ugur Avcibasi, Buket Ates, Perihan Unak, Fikriye Gul Gumuser, Suleyman Gulcemal, Kevser Kusat Ol, Sinan Akgol, Volkan Tekin
APPLIED RADIATION AND ISOTOPES
(2019)
Article
Chemistry, Multidisciplinary
Cagatay Ozada, Volkan Tekin, F. Baris Barlas, Suna Timur, Perihan Unak
Article
Chemistry, Applied
Elif Tutun, Volkan Tekin, Volkan Yasakci, Omer Aras, Perihan Unak
Summary: This study developed multifunctional theranostic probe for imaging (MRI and SPECT) and therapy (photodynamic therapy) by synthesizing Tc-99m-labeled lupulone-conjugated Fe3O4@TiO2 nanocomposites. The nanocomposites showed high radiolabeling yields and lower cell viability on cancer prostate cell lines, indicating their potential for cancer therapy in the future.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Analytical
Sibel Ay, Volkan Yasakci, Omer Aras, Perihan Unak
Summary: This study successfully developed a dual-mode imaging probe for imaging blood cells by combining single photo emission computed tomography and fluorescence. In cell experiments, the probe showed highest cell viability at a concentration of 5 μg/mL and increased binding efficiency over time.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2022)
Article
Chemistry, Analytical
T. S. Akkaya, E. Tutun, V. Yasakci, P. Unak
Summary: This study proposes a multifunctional diagnostic probe that combines magnetic resonance imaging (MRI) and single-photon emission computed tomography (SPECT) for imaging prostate cancer. The probe, [Tc-99m]Tc-GdO@SiO-BBN-DFO, was synthesized and showed potential as a novel imaging SPECT/MRI probe and bimodal imaging agent in the future. In vitro studies using healthy and cancerous prostate cells demonstrated its effectiveness.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2023)
Article
Biology
Jenson Lim, Michaela Petaroudi, Gillian Pearce, Volkan Yasakci, Perihan Unak
Summary: The experiment demonstrated that iron-based nanoparticles can be linked to macrophages without affecting their function. Both FDGMNP and MNP showed no detrimental effects on macrophage function.
BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Bilal Demir, F. Baris Barlas, Z. Pinar Gumus, Perihan Unak, Suna Timur
ACS APPLIED NANO MATERIALS
(2018)
