Article
Biochemistry & Molecular Biology
Anayt Ulla, Takayuki Uchida, Yukari Miki, Kosuke Sugiura, Atsushi Higashitani, Takeshi Kobayashi, Ayako Ohno, Reiko Nakao, Katsuya Hirasaka, Iori Sakakibara, Takeshi Nikawa
Summary: Glucocorticoids can induce muscle atrophy by increasing oxidative stress, while antioxidants such as morin can mitigate this effect. The study showed that morin effectively prevented glucocorticoid-induced muscle atrophy by reducing oxidative stress.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Physiology
Leonit Kiriaev, Ben D. Perry, David A. Mahns, Peter J. Shortland, Asma Redwan, John W. Morley, Stewart I. Head
Summary: The study showed that high dose minocycline treatment can reduce maximal isometric force production in fast-twitch EDL and impair protein synthesis in C2C12 cultured cells. These findings are significant for future research on the efficacy of minocycline treatment in neuromuscular disorders or muscle atrophy conditions.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yoshifumi Kimira, Konosuke Osawa, Yoshihiro Osawa, Hiroshi Mano
Summary: Glucocorticoids can induce muscle atrophy, but this study found that Prolyl-hydroxyproline (Pro-Hyp) has potential therapeutic effects on dexamethasone-induced muscle atrophy.
Article
Multidisciplinary Sciences
Oliver J. Bardsley, Hugh R. Matthews, Christopher L. -H. Huang
Summary: A finite element analysis modelled the diffusional generation of steady-state Ca2+ microdomains within skeletal muscle transverse (T)-tubular-sarcoplasmic reticular (SR) junctions. The model predicted elevated steady-state T-SR junctional similar to mu M-[Ca2+] elevations radially declining from maxima at the T-SR junction centre along the entire axial T-SR distance, potentially regulating cytosolic and membrane signalling molecules. These findings support the existence of physiologically significant similar to mu M-[Ca2+] T-SR microdomains in skeletal muscle.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Yasuyuki Tamai, Akiko Eguchi, Ryuta Shigefuku, Hiroshi Kitamura, Mina Tempaku, Ryosuke Sugimoto, Yoshinao Kobayashi, Motoh Iwasa, Yoshiyuki Takei, Hayato Nakagawa
Summary: Hepatic sarcopenia is associated with high mortality rates in chronic liver disease patients, with LCA levels positively correlated with muscle mass and patient survival. BCAA treatment in CLD rats increased muscle weight and serum LCA levels, showing potential for muscle hypertrophy via the TGR5-IGF1-Akt signaling pathway.
Article
Biochemistry & Molecular Biology
Marina Sciancalepore, Gabriele Massaria, Federica Tramer, Paola Zacchi, Paola Lorenzon, Annalisa Bernareggi
Summary: It is well-known that regular physical exercise has short-term and long-term benefits in reducing the risk of various diseases and improving sleep quality, cognitive level, mobility, and autonomy in the elderly. Recent evidence suggests that contracting skeletal muscles play an endocrine role. Exercise triggers the release of myokines, which control the activity of muscles as well as other tissues and organs through autocrine, paracrine, and endocrine pathways. The mechanism of myokine release is still unclear.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Cecilia Leijding, Ida Viken, Joseph D. D. Bruton, Daniel C. C. Andersson, Arthur J. J. Cheng, Hakan Westerblad
Summary: During the initial phase of fatigue, tetanic force decreases despite increasing tetanic cytosolic calcium concentration. However, the increase in calcium concentration has positive effects on force in early fatigue.
Article
Endocrinology & Metabolism
Takanaga Shirai, Tomohiro Iwata, Kazuki Uemichi, Riku Tanimura, Ryoto Iwai, Tohru Takemasa
Summary: Calorie restriction (CR) is a recognized dietary approach that has beneficial effects on the body. This study found that secretory factors present in the blood during CR can activate protein synthesis and promote mitochondrial function.
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Mathematics, Applied
Marko Sterk, Jurij Dolensek, Lidija Krizancic Bombek, Rene Markovic, Darko Zakelsek, Matjaz Perc, Viljem Pohorec, Andraz Stozer, Marko Gosak
Summary: The functionality of pancreatic islets can be characterized by the position of wave initiator regions and the velocity of spreading calcium waves. Mathematical modeling can help improve the determination of these parameters and reveal that calcium waves are primarily triggered by specific regions, with a velocity of around 80 μm/s.
COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION
(2021)
Article
Physiology
Leonardo Nogueira, Natalie K. Gilmore, Michael C. Hogan
Summary: Parvalbumin (PV) is an important cytosolic Ca2+ buffer in mouse myofibers, but not in human muscle. Inducible knockout of PV leads to increases in myofiber cytosolic free Ca2+ concentrations and slowing of Ca2+ pumping during fatigue, but does not affect fatigue-induced changes in relaxation or fatigue resistance.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Zoology
Takahiro Nomura, Kimihide Hayakawa, Naruki Sato, Takashi Obinata
Summary: The effects of mechanical stress on cultured muscle cells, specifically myofibril assembly, were investigated using a cell-stretching system. While higher concentrations of certain substances inhibited the formation and maintenance of myofibrils, periodic stretching of the myotubes enabled their formation. The stretching of myotubes led to temporary elevation of intracellular Ca2+ concentration, which was disrupted by inhibition of Ca2+ channels and suppression of Ca2+ influx. These findings indicate that periodic stretching increases intracellular Ca2+ concentration, which may promote myofibril assembly through actin-myosin interaction and phosphorylation of myosin light chains.
ZOOLOGICAL SCIENCE
(2022)
Article
Cell Biology
Binjie Yan, Yu Gui, Yanan Guo, Jiaxing Sun, Mahmoud Saifeddine, Jingti Deng, Joseph A. Hill, Morley D. Hollenberg, Zhi-Sheng Jiang, Xi-Long Zheng
Summary: This study found that (+)-JQ1 can directly inhibit smooth muscle contractility and regulate endothelial cell function by indirectly activating the PI3K/AKT/eNOS cascade. However, these effects appear to be unrelated to BRD4 inhibition.
Article
Biology
Bavat Bornstein, Lia Heinemann-Yerushalmi, Sharon Krief, Ruth Adler, Bareket Dassa, Dena Leshkowitz, Minchul Kim, Guy Bewick, Robert W. Banks, Elazar Zelzer
Summary: In this study, the molecular composition of the muscle spindle in the murine deep masseter muscle was comprehensively characterized using transcriptomic and proteomic analysis. New markers for the various tissues composing the spindle were established, providing tools to study its development and function in health and disease.
Article
Engineering, Biomedical
Sunder Neelakantan, Mohit Kumar, Emilio A. Mendiola, Haley Phelan, Vahid Serpooshan, Sakthivel Sadayappan, Reza Avazmohammadi
Summary: This study investigates the contractile behavior of the myocardium at multiple length scales in small animals. The results indicate that the contraction of the myocardium is dependent on transmural depth and relaxes faster in the direction with larger peak stresses.
ACTA BIOMATERIALIA
(2023)
Article
Multidisciplinary Sciences
Wei Qiao, Dayu Pan, Yufeng Zheng, Shuilin Wu, Xuanyong Liu, Zhuofan Chen, Mei Wan, Shiqin Feng, Kenneth M. C. Cheung, Kelvin W. K. Yeung, Xu Cao
Summary: This study reveals that divalent metal cations can activate the skeleton interoceptive circuit through the immune-neural axis to initiate new bone formation.
NATURE COMMUNICATIONS
(2022)
