Article
Endocrinology & Metabolism
Antonio Gonzalez Perez, David Vizcaya, Maria E. Saez, Marcus Lind, Luis A. Garcia Rodriguez
Summary: In this population-based study, researchers found that SGLT2 inhibitors were associated with significant cardiovascular, renal, and survival benefits among individuals with type 2 diabetes on metformin; the cardiovascular benefits were primarily driven by a reduced risk of ischemic stroke.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Multidisciplinary Sciences
Lamiae Grimaldi-Bensouda, Bernard Begaud, Jacques Benichou, Clementine Nordon, Olivia Dialla, Nicolas Morisot, Yann Hamon, Yves Cottin, Elie Serrano, Lucien Abenhaim, Emmanuel Touze
Summary: The study aimed to assess the risk of stroke and myocardial infarction associated with decongestant use, but found no increased risk in patients 70 years of age and younger without a history of prior stroke or MI. The research conducted a nested case-crossover study in France and used conditional logistic multivariable models to estimate odds ratios, ultimately concluding that decongestant use did not correlate with a higher risk of stroke or MI.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Shun-Fan Yu, Chien-Tai Hong, Wan-Ting Chen, Lung Chan, Li-Nien Chien
Summary: This study investigated the risk of cardiovascular disease (CVD) in people with type II diabetes mellitus (T2DM) who adhered to metformin after adding on a second-line antiglycemic agent. The results showed that continuous use of metformin can reduce the risk of stroke and myocardial infarction.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2023)
Article
Endocrinology & Metabolism
Suping Ling, Francesco Zaccardi, Claire Lawson, Samuel I. Seidu, Melanie J. Davies, Kamlesh Khunti
Summary: The study showed that elderly patients with type 2 diabetes who were treated with sulfonylureas and insulin had a significantly higher risk of severe hypoglycemia, but no clear evidence of increased risks of mortality. Sulfonylurea and insulin use were more relevant predictors of severe hypoglycemia and death than were glucose levels.
Article
Cardiac & Cardiovascular Systems
Francisco Jose de Abajo, Sara Rodriguez-Martin, Diana Barreira, Antonio Rodriguez-Miguel, Encarnacion Fernandez-Anton, Miguel Gil, Alberto Garcia-Lledo
Summary: The study suggests a moderate protective effect of influenza vaccination on AMI in the general population, primarily in primary prevention. The reduced risk of AMI was observed shortly after vaccination and persisted over time, with no significant association found with pneumococcal vaccine.
Article
Clinical Neurology
Robert Murphy, Catriona Reddin, Annika Rosengren, Conor J. Judge, Graeme Hankey, John Ferguson, Alberto Alvarez-Iglesias, Shahram Oveisgharan, Mohammad Wasay, Clodagh McDermott, Helle Klingenberg Iversen, Fernando Lanas, Fawaz Al-Hussain, Anna Czlonkowska, Aytekin Oguz, Adesola Ogunniyi, Albertino Damasceno, Denis Xavier, Alvaro Avezum, Xingyu Wang, Peter Langhorne, Salim Yusuf, Martin O'Donnell
Summary: A global study found that depressive symptoms are an important risk factor for acute stroke, including both ischemic and hemorrhagic strokes. Preadmission depressive symptoms were significantly associated with a higher risk of acute stroke and poorer functional outcome at 1 month after stroke.
Article
Endocrinology & Metabolism
Weiwei Dong, Zhiyong Yang
Summary: An analysis of lipid profiles and lipid control among US adult survivors of stroke and/or myocardial infarction from 2001-2018 revealed a decrease in total cholesterol, LDL, and triglyceride concentrations, as well as an improvement in lipid control rates. However, variations were observed based on sex and race.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Geriatrics & Gerontology
Kristen DeCarlo, Amisha Wallia, Raymond H. Kang, Andrew Cooper, Manisha Cherupally, Sterling A. Harris, Cassandra Aikman, David T. Liss, Ronald T. Ackermann, Matthew J. O'Brien
Summary: Despite clinical consensus to use caution in prescribing certain antidiabetic medications among older adults in poor health, these medications remain commonly used in this population.
Article
Immunology
Nick Daneman, Yi Cheng, Tara Gomes, Jun Guan, Muhammad M. Mamdani, Farah E. Saxena, David N. Juurlink
Summary: The study revealed that metronidazole is associated with an increased risk of adverse peripheral and central nervous system events compared to clindamycin, with an overall low incidence of neurological events in metronidazole recipients.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Tae-Min Rhee, Hyung-Kwan Kim, Bong-Seong Kim, Kyung-Do Han, Hyun-Jung Lee, In-Chang Hwang, Heesun Lee, Jun-Bean Park, Yeonyee E. Yoon, Yong-Jin Kim, Goo-Yeong Cho
Summary: Limited data are available on the long-term outcomes in HCM patients with significant CAD requiring revascularization. This study showed that HCM patients who underwent coronary revascularization had a significantly higher risk of cardiovascular death, SCD, ischemic stroke, and heart failure compared to the non-HCM control group.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Nicolas Girerd, John Cleland, Stefan D. Anker, William Byra, Carolyn S. P. Lam, David Lapolice, Mandeep R. Mehra, Dirk J. van Veldhuisen, Emmanuel Bresso, Zohra Lamiral, Barry Greenberg, Faiez Zannad
Summary: This study evaluated the associations between clinical events and proteomic biomarkers in patients with HF and CAD. The results showed that biomarkers associated with inflammation and remodeling mechanisms were strong predictors of various cardiovascular events.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Pyry N. Sipila, Joni V. Lindbohm, G. David Batty, Nelli Heikkila, Jussi Vahtera, Sakari Suominen, Ari Vaananen, Aki Koskinen, Solja T. Nyberg, Seppo Meri, Jaana Pentti, Charlotte Warren-Gash, Andrew C. Hayward, Mika Kivimaki
Summary: This study found that severe infections are associated with an increased risk of major cardiovascular events, with the highest risk occurring in the first month after infection. The association remained elevated throughout the follow-up period. There is a small excess risk of long-term cardiovascular disease associated with severe infections.
Article
Hematology
Avi Leader, Noa Dagan, Noam Barda, Idan Goldberg, Pia Raanani, Galia Spectre, Ran Balicer, Anat Gafter-Gvili
Summary: The study found an increased risk of undiagnosed cancer at 12 months after arterial thrombotic events (ATE), especially in patients without documented vascular risk factors or pre-existing cardiovascular disease. The relative risk of cancer was high in all subgroups, with the highest hazard ratio observed in patients without cardiovascular risk factors.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Environmental Sciences
Clara G. Sears, Erin J. Healy, Lissa F. Soares, Dana Palermo, Melissa Eliot, Yaqiang Li, Victoria Fruh, Tesleem Babalola, Katherine A. James, James M. Harrington, Gregory A. Wellenius, Anne Tjonneland, Ole Raaschou-Nielsen, Jaymie R. Meliker
Summary: Limited evidence suggests that environmental antimony exposure is associated with cardiovascular disease risk. This study found that urine antimony concentrations were positively associated with rates of acute myocardial infarction and heart failure in a Danish population who never smoked.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Clinical Neurology
Gaultier Marnat, Igor Sibon, Benjamin Gory, Sebastien Richard, Stephane Olindo, Arturo Consoli, Romain Bourcier, Maeva Kyheng, Julien Labreuche, Cyril Darganzali, Adrien ter Schiporst, Florent Gariel, Raphael Blanc, Bertrand Lapergue
Summary: The study found that mechanical thrombectomy in infective endocarditis patients presents similar safety and angiographic results compared to patients with atrial fibrillation, with a high rate of successful reperfusion. However, a lower rate of achieving a favorable outcome at three months was observed in the infective endocarditis group.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Genetics & Heredity
Marguerite R. Irvin, Colleen M. Sitlani, Raymond Noordam, Christie L. Avery, Joshua C. Bis, James S. Floyd, Jin Li, Nita A. Limdi, Vinodh Srinivasasainagendra, James Stewart, Renee de Mutsert, Dennis O. Mook-Kanamori, Leonard Lipovich, Erica L. Kleinbrink, Albert Smith, Traci M. Bartz, Eric A. Whitsel, Andre G. Uitterlinden, Kerri L. Wiggins, James G. Wilson, Degui Zhi, Bruno H. Stricker, Jerome Rotter, Donna K. Arnett, Bruce M. Psaty, Leslie A. Lange
PHARMACOGENOMICS JOURNAL
(2019)
Article
Genetics & Heredity
Sara Lindstrom, Jennifer A. Brody, Constance Turman, Marine Germain, Traci M. Bartz, Erin N. Smith, Ming-Huei Chen, Marja Puurunen, Daniel Chasman, Jeffrey Hassler, Nathan Pankratz, Saonli Basu, Weihua Guan, Beata Gyorgy, Manal Ibrahim, Jean-Philippe Empana, Robert Olaso, Rebecca Jackson, Sigrid K. Braekkan, Barbara McKnight, Jean-Francois Deleuze, Cristopher J. O'Donnell, Xavier Jouven, Kelly A. Frazer, Bruce M. Psary, Kerri L. Wiggins, Kent Taylor, Alexander P. Reiner, Susan R. Heckbert, Charles Kooperberg, Paul Ridker, John-Bjarne Hansen, Weihong Tang, Andrew D. Johnson, Pierre-Emmanuel Morange, David A. Tregouet, Peter Kraft, Nicholas L. Smith, Christopher Kabrhel
GENETIC EPIDEMIOLOGY
(2019)
Article
Multidisciplinary Sciences
Cavin K. Ward-Caviness, Paul S. de Vries, Kerri L. Wiggins, Jennifer E. Huffman, Lisa R. Yanek, Lawrence F. Bielak, Franco Giulianini, Xiuqing Guo, Marcus E. Kleber, Tim Kacprowski, Stefan Gross, Astrid Petersman, George Davey Smith, Fernando P. Hartwig, Jack Bowden, Gibran Hemani, Martina Mueller-Nuraysid, Konstantin Strauch, Wolfgang Koenig, Melanie Waldenberger, Thomas Meitinger, Nathan Pankratz, Eric Boerwinkle, Weihong Tang, Yi-Ping Fu, Andrew D. Johnson, Ci Song, Moniek P. M. de Maat, Andre G. Uitterlinden, Oscar H. Franco, Jennifer A. Brody, Barbara McKnight, Yii-Der Ida Chen, Bruce M. Psaty, Rasika A. Mathias, Diane M. Becker, Patricia A. Peyser, Jennifer A. Smith, Suzette J. Bielinski, Paul M. Ridker, Kent D. Taylor, Jie Yao, Russell Tracy, Graciela Delgado, Stella Trompet, Naveed Sattar, J. Wouter Jukema, Lewis C. Becker, Sharon L. R. Kardia, Jerome Rotter, Winfried Maerz, Marcus Doerr, Daniel Chasman, Abbas Dehghan, Christopher J. O'Donnell, Nicholas L. Smith, Annette Peters, Alanna C. Morrison
Article
Peripheral Vascular Disease
Marguerite R. Irvin, Colleen M. Sitlani, James S. Floyd, Bruce M. Psaty, Joshua C. Bis, Kerri L. Wiggins, Eric A. Whitsel, Til Sturmer, James Stewart, Laura Raffield, Fangui Sun, Ching-Ti Liu, Hanfei Xu, Adrienne L. Cupples, Rikki M. Tanner, Peter Rossing, Albert Smith, Nuno R. Zilhao, Lenore J. Launer, Raymond Noordam, Jerome Rotter, Jie Yao, Xiaohui Li, Xiuqing Guo, Nita Limdi, Aishwarya Sundaresan, Leslie Lange, Adolfo Correa, David J. Stott, Ian Ford, J. Wouter Jukema, Vilmundur Gudnason, Dennis O. Mook-Kanamori, Stella Trompet, Walter Palmas, Helen R. Warren, Jacklyn N. Hellwege, Ayush Giri, Christopher O'Donnell, Adriana M. Hung, Todd L. Edwards, Tarunveer S. Ahluwalia, Donna K. Arnett, Christy L. Avery
AMERICAN JOURNAL OF HYPERTENSION
(2019)
Article
Hematology
Sara Lindstrom, Lu Wang, Erin N. Smith, William Gordon, Astrid van Hylckama Vlieg, Mariza de Andrade, Jennifer A. Brody, Jack W. Pattee, Jeffrey Haessler, Ben M. Brumpton, Daniel I. Chasman, Pierre Suchon, Ming-Huei Chen, Constance Turman, Marine Germain, Kerri L. Wiggins, James MacDonald, Sigrid K. Braekkan, Sebastian M. Armasu, Nathan Pankratz, Rebecca D. Jackson, Jonas B. Nielsen, Franco Giulianini, Marja K. Puurunen, Manal Ibrahim, Susan R. Heckbert, Scott M. Damrauer, Pradeep Natarajan, Derek Klarin, Paul S. de Vries, Maria Sabater-Lleal, Jennifer E. Huffman, Theo K. Bammler, Kelly A. Frazer, Bryan M. McCauley, Kent Taylor, James S. Pankow, Alexander P. Reiner, Maiken E. Gabrielsen, Jean-Francois Deleuze, Chris J. O'Donnell, Jihye Kim, Barbara McKnight, Peter Kraft, John-Bjarne Hansen, Frits R. Rosendaal, John A. Heit, Bruce M. Psaty, Weihong Tang, Charles Kooperberg, Kristian Hveem, Paul M. Ridker, Pierre-Emmanuel Morange, Andrew D. Johnson, Christopher Kabrhel, David-Alexandre Tregouet, Nicholas L. Smith, Emma Busenkell, Renae Judy, Julie Lynch, Michael Levin, J. H. Krishna Aragam, Mark Chaffin, Mary Haas, Themistocles L. Assimes, Jie Huang, Kyung Min Lee, Qing Shao, C. Kabrhel, Yunfeng Huang, Yan V. Sun, Marijana Vujkovic, Danish Saleheen, Donald R. Miller, Peter Reaven, Scott DuVall, William Boden, Saiju Pyarajan, Peter Henke, C. Kooperberg, J. Michael Gaziano, John Concato, Daniel J. Rader, Kelly Cho, Kyong-Mi Chang, Peter W. F. Wilson, Philip S. Tsao, Sekar Kathiresan, Andrea Obi
Article
Genetics & Heredity
Madeline H. Kowalski, Huijun Qian, Ziyi Hou, Jonathan D. Rosen, Amanda L. Tapia, Yue Shan, Deepti Jain, Maria Argos, Donna K. Arnett, Christy Avery, Kathleen C. Barnes, Lewis C. Becker, Stephanie A. Bien, Joshua C. Bis, John Blangero, Eric Boerwinkle, Donald W. Bowden, Steve Buyske, Jianwen Cai, Michael H. Cho, Seung Hoan Choi, Helene Choquet, L. Adrienne Cupples, Mary Cushman, Michelle Daya, Paul S. de Vries, Patrick T. Ellinor, Nauder Faraday, Myriam Fornage, Stacey Gabriel, Santhi K. Ganesh, Misa Graff, Namrata Gupta, Jiang He, Susan R. Heckbert, Bertha Hidalgo, Chani J. Hodonsky, Marguerite R. Irvin, Andrew D. Johnson, Eric Jorgenson, Robert Kaplan, Sharon L. R. Kardia, Tanika N. Kelly, Charles Kooperberg, Jessica A. Lasky-Su, Ruth J. F. Loos, Steven A. Lubitz, Rasika A. Mathias, Caitlin P. McHugh, Courtney Montgomery, Jee-Young Moon, Alanna C. Morrison, Nicholette D. Palmer, Nathan Pankratz, George J. Papanicolaou, Juan M. Peralta, Patricia A. Peyser, Stephen S. Rich, Jerome Rotter, Edwin K. Silverman, Jennifer A. Smith, Nicholas L. Smith, Kent D. Taylor, Timothy A. Thornton, Hemant K. Tiwari, Russell P. Tracy, Tao Wang, Scott T. Weiss, Lu-Chen Weng, Kerri L. Wiggins, James G. Wilson, Lisa R. Yanek, Sebastian Zollner, Kari E. North, Paul L. Auer, Laura M. Raffield, Alexander P. Reiner, Yun Li
Article
Public, Environmental & Occupational Health
Barbara N. Harding, Kerri L. Wiggins, Paul N. Jensen, Barbara McKnight, Bruce M. Psaty, Susan R. Heckbert, James S. Floyd
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2020)
Article
Hematology
Louisa Goumidi, Florian Thibord, Kerri L. Wiggins, Ruifang Li-Gao, Mickael R. Brown, Astrid van Hylckama Vlieg, Joan-Carles Souto, Jose-Manuel Soria, Manal Ibrahim-Kosta, Noemie Saut, Delphine Daian, Robert Olaso, Philippe Amouyel, Stephanie Debette, Anne Boland, Pascal Bailly, Alanna C. Morrison, Denis O. Mook-Kanamori, Jean-Francois Deleuze, Andrew Johnson, Paul S. de Vries, Maria Sabater-Lleal, Jacques Chiaroni, Nicholas L. Smith, Frits R. Rosendaal, Daniel Chasman, David-Alexandre Tregouet, Pierre-Emmanuel Morange
Summary: Genetic risk score analysis is commonly used to predict individual risk for complex diseases. In the case of venous thrombosis, it is recommended to use 4 SNPs to assess the impact of the ABO locus on risk, as different haplotypes have varying associations with VT risk. Further research is needed to fully understand the biological effects of the ABO locus on cardiovascular traits.
Article
Clinical Neurology
Yao Hu, Jeffrey W. Haessler, Regina Manansala, Kerri L. Wiggins, Arden Moscati, Alexa Beiser, Nancy L. Heard-Costa, Chloe Sarnowski, Laura M. Raffield, Jaeyoon Chung, Sandro Marini, Christopher D. Anderson, Jonathan Rosand, Huichun Xu, Xiao Sun, Tanika N. Kelly, Quenna Wong, Leslie A. Lange, Jerome Rotter, Adolfo Correa, Ramachandran S. Vasan, Sudha Seshadri, Stephen S. Rich, Ron Do, Ruth J. F. Loos, William T. Longstreth, Joshua C. Bis, Bruce M. Psaty, David L. Tirschwell, Themistocles L. Assimes, Brian Silver, Simin Liu, Rebecca Jackson, Sylvia Wassertheil-Smoller, Braxton D. Mitchell, Myriam Fornage, Paul L. Auer, Alex P. Reiner, Charles Kooperberg
Summary: In this study, whole-genome sequencing data from ancestrally diverse populations were used to identify novel loci associated with stroke and its subtypes. The findings suggest the potential benefits of combining whole-genome sequencing data with populations of diverse genetic backgrounds, but also highlight the need to increase genome coverage and sample sizes.
Article
Multidisciplinary Sciences
Nuzulul Kurniansyah, Matthew O. Goodman, Tanika N. Kelly, Tali Elfassy, Kerri L. Wiggins, Joshua C. Bis, Xiuqing Guo, Walter Palmas, Kent D. Taylor, Henry J. Lin, Jeffrey Haessler, Yan Gao, Daichi Shimbo, Jennifer A. Smith, Bing Yu, Elena V. Feofanova, Roelof A. J. Smit, Zhe Wang, Shih-Jen Hwang, Simin Liu, Sylvia Wassertheil-Smoller, JoAnn E. Manson, Donald M. Lloyd-Jones, Stephen S. Rich, Ruth J. F. Loos, Susan Redline, Adolfo Correa, Charles Kooperberg, Myriam Fornage, Robert C. Kaplan, Bruce M. Psaty, Jerome I. Rotter, Donna K. Arnett, Alanna C. Morrison, Nora Franceschini, Daniel Levy, Tamar Sofer
Summary: Polygenic risk scores can be used to predict an individual's disease risk based on genetic markers. In this study, a polygenic risk score for hypertension is developed and tested in a multi-ethnic cohort, showing an association with increased likelihood of developing hypertension 4-6 years later.
NATURE COMMUNICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Matthew P. Huber, Jay A. Pandit, Paul N. Jensen, Kerri L. Wiggins, Ravi B. Patel, Benjamin H. Freed, Alain G. Bertoni, Sanjiv J. Shah, Susan R. Heckbert, James S. Floyd
Summary: Impaired left atrial (LA) strain is associated with subclinical atrial arrhythmias detected from extended ambulatory cardiac monitoring. This association remains even after adjusting for conventional measures of LA structure and function.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Multidisciplinary Sciences
Nuzulul Kurniansyah, Matthew O. Goodman, Alyna T. Khan, Jiongming Wang, Elena Feofanova, Joshua C. Bis, Kerri L. Wiggins, Jennifer E. Huffman, Tanika Kelly, Tali Elfassy, Xiuqing Guo, Walter Palmas, Henry J. Lin, Shih-Jen Hwang, Yan Gao, Kendra Young, Gregory L. Kinney, Jennifer A. Smith, Bing Yu, Simin Liu, Sylvia Wassertheil-Smoller, JoAnn E. Manson, Xiaofeng Zhu, Yii-Der Ida Chen, I-Te Lee, C. Charles Gu, Donald M. Lloyd-Jones, Sebastian Zoellner, Myriam Fornage, Charles Kooperberg, Adolfo Correa, Bruce M. Psaty, Donna K. Arnett, Carmen R. Isasi, Stephen S. Rich, Robert C. Kaplan, Susan Redline, Braxton D. Mitchell, Nora Franceschini, Daniel Levy, Jerome I. Rotter, Alanna C. Morrison, Tamar Sofer
Summary: This study evaluates the performance and limitations of polygenic risk scores (PRSs) for multiple blood pressure phenotypes in diverse population groups. The authors compare different methods to construct PRSs, including clumping-and-thresholding (PRSice2) and LD-based (LDPred2) approaches. They find that PRS-CSx, a weighted sum of PRSs developed from multiple independent GWAS, performs best across all race/ethnic backgrounds. Stratified analysis shows that PRSs are more predictive of blood pressure in females, individuals without obesity, and middle-aged individuals.
NATURE COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Xue Liu, Xianbang Sun, Yuankai Zhang, Wenqing Jiang, Meng Lai, Kerri L. Wiggins, Laura M. Raffield, Lawrence F. Bielak, Wei Zhao, Achilleas Pitsillides, Jeffrey Haessler, Yinan Zheng, Thomas W. Blackwell, Jie Yao, Xiuqing Guo, Yong Qian, Bharat Thyagarajan, Nathan Pankratz, Stephen S. Rich, Kent D. Taylor, Patricia A. Peyser, Susan R. Heckbert, Sudha Seshadri, Eric Boerwinkle, Megan L. Grove, Nicholas B. Larson, Jennifer A. Smith, Ramachandran S. Vasan, Annette L. Fitzpatrick, Myriam Fornage, Jun Ding, April P. Carson, Goncalo Abecasis, Josee Dupuis, Alexander Reiner, Charles Kooperberg, Lifang Hou, Bruce M. Psaty, James G. Wilson, Daniel Levy, Jerome I. Rotter, Joshua C. Bis, Claudia L. Satizabal, Dan E. Arking, Chunyu Liu
Summary: This study found that high low-density lipoprotein cholesterol may underlie the complex relationships between mtDNA CN and vascular atherosclerosis.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Letter
Urology & Nephrology
Kerri L. Wiggins, James S. Floyd, Nisha Bansal, Bryan Kestenbaum, Susan R. Heckbert
Article
Hematology
Christina R. Evans, Ching-Ping Hong, Aaron R. Folsom, Susan R. Heckbert, Nicholas L. Smith, Kerri Wiggins, Pamela L. Lutsey, Mary Cushman
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)