Journal
JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM
Volume 904, Issue 1-3, Pages 69-73Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.theochem.2009.02.033
Keywords
Cope rearrangement; Electronic effect; Theoretical calculation; Activation barrier; Reaction energy
Categories
Funding
- Chinese Academy of Sciences [2005012]
- National Natural Science Foundation of China [20872105, 40673022]
- Natural Science Foundation of Qinghai Province [2006-G-105]
- Qinglan Project ofjiangsu Province [Bu 109805]
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The electronic effects of an electron-withdrawing group (exemplified by formyl group) on the kinetic and thermodynamic aspects of substituted 1,5-enyne. 1,5-diyne, and 1,2-diene-5-yne Cope rearrangements were investigated by means of DFT and CBS-QB3 calculations. The energy barriers of the formyl substituted reactions are lower than those of the unsubstituted ones almost in all cases, and the barriers will be further lowered when catalyzed by ACl(3), The most obvious electronic effect was calculated for the C-2 formyl substituted 1,5-enyne rearrangements, which have activation barriers of 27.1 and 18.1 kcal/mol, respectively, for the uncatalyzed and catalyzed reactions. The charge transfer induced by the electron-withdrawing group and stabilization of the charge by Lewis acid are responsible for the different energetic profiles. The formyl substitution will change the thermodynamic profiles of the transformations, notablely, increase the reaction enthalpies of the 1,5-diyne and 1,2-diene-5-yne rearrangements by over 5.0 kcal/mol, as result of the stabilization effect of a formyl substitution attached directly to the unsaturated moieties of the products. (c) 2009 Elsevier B.V. All rights reserved.
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