Article
Forestry
Liuyang Han, Xiangna Han, Guoqing Liang, Xingling Tian, Fang Ma, Suqin Sun, Yafang Yin, Guanglan Xi, Hong Guo
Summary: Waterlogged archaeological wood may degrade due to long-term immersion in microbial activity environments. A study on waterlogged fir wood from the Shengbeiyu shipwreck using SDVS and 2D COS-IR spectroscopy revealed inhomogeneous degradation and higher sorption hysteresis in decay regions compared to sound regions. This study demonstrates the efficacy of SDVS and 2D COS-IR spectroscopy in evaluating the degradation state of waterlogged wood and the existence of differences in hygroscopicity and chemistry among visually similar samples from the same shipwreck.
Article
Biochemistry & Molecular Biology
Wei-Ting Du, Yen-Ling Kuan, Shiao-Wei Kuo
Summary: In this study, a poly(cyclohexene carbonate) (PCHC) was synthesized through alternative ring-opening copolymerization. The results showed that PCHC blends with poly(vinyl phenol) (PVPh) were miscible due to intermolecular hydrogen bonding. However, the weak hydrogen bonding interactions resulted in a negative deviation in the glass transition temperatures (T-g).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Characterization & Testing
Lidong Feng, Sheng Xiang, Yanlong Liu, Xinchao Bian, Gao Li, Xuesi Chen
Summary: An analytical method using gas chromatography with an internal standard was developed to quantitatively determine residual monomers in PLCL, which showed high precision with RSD less than 5.6% and 4.3% for LA and CL measurements, respectively. The recovery rate of standard addition for LA and CL in PLCL was between 96.5%-101.5% and 98.4%-104.2%, with RSD not exceeding 2.0%, indicating the method was sufficiently accurate.
Article
Polymer Science
Eduard-Marius Lungulescu, Traian Zaharescu
Summary: This study discusses the irradiation consequences on SIS/PCL blends, focusing on oxidation initiation. Three characterization methods are used: chemiluminescence, differential scanning calorimetry, and FTIR spectroscopy. The inhibition protection of PCL on the faster oxidation of SIS is related to the activation energies and kinetic parameters of degradation during accelerated damaging of blended polymers.
Article
Engineering, Chemical
Keziban Huner
Summary: Conductive polymers (P3ANA and PEDOT:PSS) were mixed with biocompatible and biodegradable PCL to prepare electrospun nanofibers. The nanofibers containing 10% P3ANA showed the highest antioxidant activity and were non-toxic to cells. The nanofiber with the highest amount of P3ANA also had a higher anodic current value than other P3ANA nanofibers.
POLYMER ENGINEERING AND SCIENCE
(2023)
Article
Materials Science, Textiles
Rezvan Mohamadinooripoor, Soheila Kashanian, Kobra Omidfar
Summary: Electrospun composite mats of PCL/PEE were used to fabricate PCL-PEE sutures with desirable mechanical and antibacterial properties. The sutures showed promising characteristics including sustained drug release, high tensile strength, antifungal effects, and accelerated wound healing.
FIBERS AND POLYMERS
(2023)
Article
Polymer Science
Valerio Loianno, Antonio Baldanza, Giuseppe Scherillo, Pellegrino Musto, Giuseppe Mensitieri
Summary: The sorption of pure CO2, CH4, and CO2/CH4 binary gas mixtures in amorphous glassy PPO was studied at 35 degrees C up to 1000 Torr. A combination of barometry and FTIR spectroscopy in the transmission mode was used to measure the sorption of gases in polymers. The solubility of CO2 in the binary mixtures was found to be similar to that of pure CO2 up to a total pressure of 1000 Torr and for CO2 mole fractions of about 0.5 and 0.3. The NET-GP modeling approach was employed to fit the solubility data of pure gases and to predict the solubility of CO2/CH4 mixed gases in PPO, with a deviation of less than 9.5% from experimental results for CO2 solubility.
Article
Polymer Science
Mario Ivan Penas, Connie Ocando, Evis Penott-Chang, Maryam Safari, Tiberio A. Ezquerra, Esther Rebollar, Aurora Nogales, Rebeca Hernandez, Alejandro J. Mueller
Summary: In this study, multiphasic thin films containing PCL, PBS, and PBS-ran-PCL were prepared and characterized using various techniques, showing variations in component composition and complex morphologies. The films obtained were semicrystalline, with a dominant component morphology and traces of other components revealed by s-SNOM/nano-FTIR.
Article
Polymer Science
Victoria J. Barber, Meredith A. Borden, Jill W. Alty, Ly D. Tran, Hilmar Koerner, Luke A. Baldwin, Erik J. Alexanian, Frank A. Leibfarth
Summary: There is an increasing demand for degradable polymers in sustainable plastics and medical implants. To improve their usability, it is necessary to have a better understanding of degradation factors and develop new tools for modulation. In this study, poly(caprolactone) was modified through C-H xanthylation, resulting in changes in material properties and slower degradation. The interplay between molecular and materials characteristics was found to impact the degradation rate.
Article
Materials Science, Multidisciplinary
Hongwen Sun, Jiachun Feng
Summary: The study investigated the nucleation effect of the synthesized nucleating agent Ca-HHPA on PCL by different thermal treatments. The results showed that Ca-HHPA80-200 had a significantly improved nucleation efficiency compared to Ca-HHPA80 under similar dosages.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Polymer Science
Xing Li, Wenqing Xu, Xiaohua Chang, Ying Zheng, Lingling Ni, Guorong Shan, Yongzhong Bao, Pengju Pan
Summary: This study reports on the controlled synthesis, stepwise crystallization kinetics, and crystallization-induced microphase separation and structural evolution of a novel end-functionalized supramolecular polymer PCL-Thy. The double-crystalline nature of PCL-Thy was observed, with thymine units and PCL blocks crystallizing and melting in a sequential manner. This work provides important insights into crystallization-induced microphase separation and hierarchical ordering in double-crystalline supramolecular polymers.
Article
Chemistry, Physical
Alena Opalkova Siskova, Katarina Mosnackova, Marta Musiol, Andrej Opalek, Maria Buckova, Piotr Rychter, Anita Eckstein Andicsova
Summary: Packaging materials made of antimicrobial poly(epsilon-caprolactone) (PCL) can reduce food waste and improve the freshness and shelf life of fruits and vegetables.
Article
Chemistry, Applied
Aoi Nakashima, Kaho Kohori, Kazuya Yamamoto, Jun-ichi Kadokawa
Summary: Chitin hexanoate-graft-poly(epsilon-caprolactone) (ChHex-g-PCL) was found to be thermoplastic, and the thermoplasticity was confirmed by the formation of a melt-pressed film. Chitin hexanoates were prepared by hexanoylation of chitin and then the surface-initiated ring-opening graft polymerization of epsilon-caprolactone was conducted to graft PCL chains onto the hydroxy groups of chitin hexanoates. The molar substitution and degree of polymerization of the PCL graft chains were influenced by the catalyst, reaction time, and degree of substitution.
CARBOHYDRATE POLYMERS
(2022)
Article
Engineering, Environmental
Matias Menossi, Florencia Salcedo, Nazarena Rivilli, Andres Torres Nicolini, Vera A. Alvarez, Leandro N. Luduena
Summary: Novel formulations based on corn starch, thermoplastic starch, poly (lactic acid), and poly (epsilon-caprolactone) were developed for agricultural mulch films. The addition of poly (epsilon-caprolactone) had slight effects on the properties of PLA/CS and PLA/TPS blends. Bioassays showed that the use of these biodegradable mulch films based on PLA/CS and PLA/TPS had positive effects on the growth of tomato plants, comparable to low-density polyethylene.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Agricultural Engineering
Weijun Yang, Yanlin Zhu, Yongbin He, Liqiang Xiao, Pengwu Xu, Debora Puglia, Piming Ma
Summary: In this study, nanocomposites of PLLA-PCL-lignin were prepared to improve the mechanical and thermal properties of PLA. The results showed that the nanocomposites had increased impact strength and UV-B resistance. Additionally, annealing treatment improved the storage modulus of the nanocomposites.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Engineering, Chemical
Valerio Loianno, Giuseppe Mensitieri, Antonio Baldanza, Giuseppe Scherillo, Pellegrino Musto
Summary: A hyphenated technique combining FTIR Spectroscopy and Barometry was used to study the transport properties of pure and mixed gases in rubbery polymers. The study focused on the transport of pure CO2 and CH4 in polydimethylsiloxane (PDMS) under ambient temperature and pressure conditions. Both gas phase and solid polymer phase were quantitatively analyzed. The results demonstrated the feasibility of applying the same approach to the sorption of gas mixtures, which is currently a difficult task.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Engineering, Multidisciplinary
Valerio Loianno, Giuseppe Mensitieri
Summary: A dynamic method for the storage of calibration gas mixtures is presented using thermal mass flow controllers (MFCs) connected to a dead end volume. The approach relies on barometry to calibrate the unknown constant volume and two MFCs which regulate the flow rate of carbon dioxide and methane respectively. Binary gas mixtures of these components are prepared and stored within the calibrated volume tank up to 9 bar at ambient temperature. Thermodynamic data of pressure, temperature and density of the gas mixtures are retrieved. The expanded uncertainties at 95% confidence level of the molar fraction and the density of the mixture are evaluated. FTIR Spectroscopy is used in situ to analyze the gas mixtures.
MEASUREMENT SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Antonio Baldanza, Maria Giovanna Pastore Carbone, Cosimo Brondi, Anastasios C. Manikas, Giuseppe Mensitieri, Christos Pavlou, Giuseppe Scherillo, Costas Galiotis
Summary: The study demonstrates the successful incorporation of graphene monolayers into a polymer matrix, resulting in a nanolaminate material with improved mechanical properties and gas barrier performance. This novel material has potential applications in various fields.
Article
Engineering, Chemical
A. Baldanza, G. Scherillo, G. Mensitieri, C. Panayiotou
Summary: Activity coefficients of solutes at infinite dilution are important in thermodynamics, and numerical methods are often required to calculate them. This study presents a perturbation method for deriving analytical expressions for the chemical potential or activity coefficient of solute at infinite dilution. The derived equations are validated by comparing them with numerical calculations and experimental data.
CHEMICAL ENGINEERING SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Antonio Baldanza, Domenico Mallamace, Giuseppe Mensitieri, Cosimo Brondi, Pellegrino Musto, Giuseppe Scherillo
Summary: This article provides a critical overview of experimental results and theoretical models for the sorption of low molecular weight compounds in Cu-BTC MOF, focusing on vibrational spectroscopy results and adsorption thermodynamics interpretation. The Rigid Adsorbent Lattice Fluid (RALF) model and its modification RALFHB model are introduced to address specific interactions and heterogeneity of adsorbent cages in Cu-BTC MOF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Francesco Mallamace, Giuseppe Mensitieri, Martina Salzano de Luna, Domenico Mallamace
Summary: Interactions between nanoparticles have a significant impact on their organization and dynamics. The competition between hydrophobic and hydrophilic forces in nanoparticle solutions has been observed to undergo a transition from hydrophilic to hydrophobic behavior with increasing temperature. This transition is dependent on temperature and nanoparticle volume fraction, and the hydrophobic effect plays a crucial role in determining the interaction properties of the studied nanostructures' surface.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Daniela Garcia, Martina Salzano de Luna, Giuseppe Mensitieri, Mariano Escobar, Marcela Mansilla, Antonio Baldanza
Summary: The study focuses on the reinforcement network in elastomer compounds, which is highly relevant for their practical application due to the significant influence of morphology on material properties. In this research, the viscoelastic and dielectric behavior of vulcanized SBR reinforced with CNTs of varying amounts were investigated and compared with unfilled SBR and SBR reinforced with conventional carbon black. DSC measurements highlighted potential differences in glass transition temperatures, dielectric analysis estimated the percolation threshold value, and DMA measurements were performed to obtain E' and E'' in a wide temperature range. The analysis of the activation energy shed light on the reinforcement mechanism in the nanocomposites.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Polymer Science
Giuseppe Scherillo, Giuseppe Mensitieri, Antonio Baldanza, Valerio Loianno, Pellegrino Musto, Marianna Pannico, Andrea Correa, Antonio De Nicola, Giuseppe Milano
Summary: This study combines experimental and theoretical approaches to gain a molecular-scale understanding of the state of CO2 molecules absorbed in glassy poly(ether imide) (PEI), providing a comprehensive physicochemical picture.
Article
Multidisciplinary Sciences
Antonio Baldanza, Valerio Loianno, Giuseppe Mensitieri, Giuseppe Scherillo
Summary: This study investigates the depression of glass transition temperature (T-g) in polymer matrices when in contact with low molecular weight compounds. The mechanical action of compressive stress exerted by the pressure of the fluid phase also affects T-g. A modeling approach based on the Gibbs-Di Marzio criterion is proposed to predict rubbery-glassy states maps of polymer-penetrant mixtures. The configurational entropy is modeled using the Non-Random Hydrogen Bond lattice fluid theory.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
(2023)
Article
Mechanics
Cosimo Brondi, Nicolo G. Di Novo, Nicola M. Pugno, Giuseppe Mensitieri, Massimiliano Fraldi
Summary: The spread of respiratory diseases through saliva droplets can be affected by the water evaporation process, which influences virus viability. The drying time of virus-laden droplets is influenced by environmental conditions, physical properties, and wetting regime. By simulating the evaporation behavior and drying time of aqueous sodium chloride droplets and a surrogate virus (MS2) under different wetting regimes and ambient conditions, the importance of wetting regimes on evaporation behavior and drying time was revealed.
Article
Polymer Science
Valerio Loianno, Antonio Baldanza, Giuseppe Scherillo, Pellegrino Musto, Giuseppe Mensitieri
Summary: The sorption of pure CO2, CH4, and CO2/CH4 binary gas mixtures in amorphous glassy PPO was studied at 35 degrees C up to 1000 Torr. A combination of barometry and FTIR spectroscopy in the transmission mode was used to measure the sorption of gases in polymers. The solubility of CO2 in the binary mixtures was found to be similar to that of pure CO2 up to a total pressure of 1000 Torr and for CO2 mole fractions of about 0.5 and 0.3. The NET-GP modeling approach was employed to fit the solubility data of pure gases and to predict the solubility of CO2/CH4 mixed gases in PPO, with a deviation of less than 9.5% from experimental results for CO2 solubility.
Article
Chemistry, Multidisciplinary
V. Loianno, M. Pannico, F. S. Gentile, F. Pascale, G. Mensitieri, P. Musto
Summary: The host/guest molecular interactions and H-bonding clustering in the H2O/HKUST-1 system were investigated using in-situ Fourier transform infrared spectroscopy. The results were interpreted through QM vibrational analysis of the host/guest adduct and H2O clusters. It was found that six-membered water clusters with specific conformations were the predominant species within the metal organic framework nanocavities, and cyclic trimers were also identified.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Polymer Science
Cosimo Brondi, Angela Marotta, Giovanni Filippone, Giuseppe Mensitieri, Martina Salzano de Luna, Veronica Ambrogi
Summary: Vitrimers are a class of polymers that combine the properties of traditional thermosets and thermoplastics. This study analyzes the curing reaction of an epoxy/anhydride resin to understand the reaction mechanism and structure of the crosslinked network, aiming to develop desirable materials.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Article
Chemistry, Physical
Xinlei Chen, Shiyi Chen, Xuele Lin, Jingxuan Zhou, Xingjun Gao, Yaoqi Zhen, Xiaodan Ma, Shouwen Jin, Linfang Shi, Hui Liu, Daqi Wang
Summary: Nine mixed-ligand Cd2+ complexes with different geometric structures were synthesized and characterized. The complexes exhibit various coordination modes and form both intra- and intermolecular hydrogen bonds.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Rupali Mahajan, Abhishek Sharma, Bhagyashree Patra, Lijo Mani, Parul Grover, Sandeep Kumar, Santosh Kumar Guru, Gananadhamu Samanthula, Amol G. Dikundwar, Amit Asthana
Summary: This research article provides a comprehensive characterization and toxicological assessment of a photoisomeric impurity of the antianemic drug Roxadustat. The impurity has a distinct structure compared to the drug and its formation due to light exposure is a concern. Through various experiments, including single crystal XRD, physicochemical characterization, and in vitro cytotoxicity assays, the researchers confirmed the structure of the impurity, evaluated its conversion with Roxadustat, and assessed its toxicological activity. These findings contribute to the understanding of drug stability, safety, and formulation development.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Laila S. Alqarni, Azzah M. Alghamdi, Nuha Y. Elamin, A. Rajeh
Summary: The solution casting method was used to produce a new type of nanocomposites made of chitosan, gelatin, and co-doped ZnO nanoparticles. The addition of 3.5% co-doped ZnO nanoparticles improved the physicochemical characteristics and antimicrobial effects of the nanocomposites, indicating their significant potential in food packaging and energy storage.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Ruchi Gaur
Summary: The structure and intermolecular interactions of a newly synthesized bis-chalcone THXA were studied using experimental and computational methods. The importance of non-covalent interactions such as pi center dot center dot center dot pi, C-H center dot center dot center dot S, and C-H center dot center dot center dot pi was revealed.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Andrii Bazylevich, Leonid Patsenker, Sarit Aviel-Ronen, Gary Gellerman
Summary: Drug combination therapy is commonly used for treating various skin disorders, but its effectiveness is often limited. In this study, researchers synthesized conjugates of anti-pigmenting drugs and hyaluronic acid (HA) to improve treatment efficacy. These HA-drug conjugates exhibited measurable drug release profiles and demonstrated superior depigmentation effects compared to control groups in a swine model.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Xiaodan Ma, Xinlei Chen, Yaoqi Zhen, Xunjie Zheng, Chengzhe Shi, Shouwen Jin, Bin Liu, Bin Chen, Daqi Wang
Summary: Cocrystallization experiments between minoxidil and aryl acids coformers resulted in the successful formation of multi-component samples. The nature of these samples was determined using various techniques and their structural and supramolecular aspects were investigated. The outcomes revealed the importance of nonbonding contacts and different types of interactions in stabilizing and expanding the crystal structures.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Najla A. Alshaye, Magdy A. Ibrahim, Al-Shimaa Badran
Summary: The chemical behavior of 3-substituted-6,8-dimethylchromones towards phenylhydrazine was examined. Different reaction conditions produced various products, and the molecular geometries and reactivity descriptors of the compounds were also investigated. The results suggest that these compounds are suitable for nonlinear optical applications.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Hayette Alliouche, Houria Bouria, Rafik Bensegueni, Mounia Guergouri, Abdelmalek Bouraiou, Ali Belfaitah
Summary: In this paper, a combined experimental and theoretical study was conducted to synthesize and characterize new 2-quinolone-piperidine and -morpholine hybrids. The results from experiments were validated using computational calculations, and the affinity between these compounds and Acetylcholinesterase/Butyrylcholinesterase was estimated through molecular docking.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Wei-Min Chen, Juan-Juan Shao, Yi Zhang, Zhen-Dong Xue, Peng-Lai Liu, Jian-Ling Ni, Li-Zhuang Chen, Qiang Gao, Fang-Ming Wang
Summary: This study synthesized and characterized a novel Mn-based LMOF, and achieved good results in detecting heavy metal Al3+ in water, showing good stability, high selectivity and sensitivity. This provides new insights into the potential applications of Mn-based MOFs in chemical sensing.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Jun-Xia Li, Yi-Jing Lu, Ke-Ying Quan, Li-Bing Wu, Xun Feng, Wei-Zhou Wang
Summary: This study synthesized two cobalt(II) complexes and analyzed their crystal structures using single-crystal X-ray diffraction. The results showed that the crystal structures of these complexes were different, and they exhibited different crystal packing and magnetic properties.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Yang Li, Yan Zhang, Hong Xu, Min Li, Zhen Li, Zi-yu Song, Ji-shi Chen, Yan-Jun Liu, Yong Sun, Zhao Yang
Summary: This study reports the synthesis and solid-state characterization of a new pharmaceutical cocrystal, PRO-BPE, which can enhance the solubility of the highly water-insoluble prodrug probenecid. The PRO-BPE cocrystals were found to have superior water solubility compared to pure PRO. This research provides valuable insights into improving the solubility of poorly soluble drugs.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Lucas G. B. Felicio, Bianca B. M. Vieira, Ivana S. Lula, Renata Diniz, Frank Alexis, Flavio B. Miguz, Frederico B. De Sousa
Summary: A novel spiropyran derivative was synthesized for heavy metals sensing in water. The results demonstrated that the new derivative can serve as a rapid, sensitive, and simple tool for detecting Hg2+ ions in water with high selectivity.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Junqing Meng, Jie Wang, Lijuan Wang, Chunhui Lyu, Haiyan Chen, Yingpei Lyu, Baisheng Nie
Summary: Material modification with low surface energy can achieve lower surface free energy on micro-and nano-rough structures, which is crucial for developing superhydrophobic surfaces. In this study, attapulgite (APT) was modified with alkylamine, alkylammonium salt, and stearic acid, and the interaction between low surface materials and attapulgite was explained. The results showed that the hydrophobicity of APT was significantly modified by the modifiers, and the surface free energy of the composites first decreased and then increased with increasing molecular number of low surface energy monomers.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Karan Goswami, Dipak Das, Parthasarathi Bera, Sounak Roy, Md. Motin Seikh, Prasanta Kumar Sinha, Arup Gayen
Summary: This work presents the development of a simple and highly active heterogeneous Pd catalyst for Suzuki-Miyaura carbon-carbon cross-coupling reaction. The NiPdFe-1 catalyst shows the best activity and stability among the prepared catalysts. It efficiently promotes the coupling reaction between aryl bromide and phenyl boronic acid under mild reaction conditions with high isolated yields.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Ekta Pardhi, Devendra Singh Tomar, Rahul Khemchandani, Gananadhamu Samanthula, Pankaj Kumar Singh, Neelesh Kumar Mehra
Summary: The main aim of this study was to prepare a drug-drug coamorphous system to improve the physiochemical properties, solubility and stability of Apremilast and Indomethacin. Various solid-state characterization techniques were used to characterize the prepared system. Molecular level interactions were studied using molecular modeling and ATR-FTIR and 1H NMR. Solubility and dissolution studies showed the benefits of the coamorphous system. The system was found to be stable for a period of five months. Permeation study also demonstrated improved flux for both drugs compared to their crystalline forms. The coamorphous system showed anti-psoriatic and anti-melanogenic activity based on molecular docking results. Overall, the developed CAM-based supersaturated system exhibited improved physicochemical properties and physical stability.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
