Article
Crystallography
Sulaiman A. Al Yousef, Asma S. Al-Wasidi, Ibtisam I. S. AlZahrani, Hotoun I. Thawibaraka, Ahmed M. Naglah, Shaima A. El-Mowafi, Omar B. Ibrahim, Moamen S. Refat, Ahmed Gaber
Summary: Adrenaline reacts with metal chlorides in methanol to form metal ion adducts with clear composition. These adducts exhibit stronger antibacterial and antifungal properties compared to free adrenaline compounds, with their chemical structures and compositions analyzed in detail.
Article
Chemistry, Multidisciplinary
Chencheng Shen, Xianglong Cai, Tiancheng Zheng, Yuxi Jia, Dong Liu, Jinbo Liu, Jingwei Guo
Summary: This study demonstrated the application of mid-infrared lasers in free space, generating stimulated Raman scattering lasers using mixed gases of hydrogen and deuterium to reduce the threshold of mid-IR laser generation and achieve high power output. Multiple spectral mid-IR Raman lasers were also generated, showcasing the potential of this convenient method.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Analytical
Shihao Wu, Linpei Dong, Jiahua Ji, Peng Zhao, Ge Song, Xiaojun Wu, Jifen Wang, Yunfeng Zhang, Jingjing Wang
Summary: This study established a rapid and efficient method for detecting As, Hg, Tl, and Pb in biological tissues using ME-XRF, and applied it to actual cases. A detection model based on the fundamental parameter (FP) method was developed through optimizing the instrument's operating conditions and sample preparation method. Through systematic evaluation and validation, the feasibility of using ME-XRF in forensic toxicology analysis was confirmed.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2023)
Article
Chemistry, Analytical
Shihao Wu, Linpei Dong, Jiahua Ji, Peng Zhao, Ge Song, Xiaojun Wu, Jifen Wang, Yunfeng Zhang, Jingjing Wang
Summary: This study established a rapid and efficient method for quantification of As, Hg, Tl, and Pb in biological tissues using ME-XRF and applied it to actual cases. By optimizing the instrument's operating conditions and sample preparation, a new detection model for biological tissues was developed. The feasibility of using ME-XRF in forensic toxicology analysis was confirmed through systematic evaluation and validation.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2023)
Article
Chemistry, Physical
Lubna Afroz, M. H. Moinuddin Khan, H. M. Vagdevi, Malathesh Pari, R. Mohammed Shafeeulla, Anees Fathima
Summary: This study investigates the combination of experimental and pharmacological studies on 3d-metal chelates of a novel ligand (HBH) bearing isatin moiety. The metal-coordinated compounds exhibited tridentate coordination and octahedral geometry. A modified cobalt(II) metal complex carbon electrode served as a reliable sensor for identifying heavy metal ions using CV and LSV methods. Additionally, the study explores the antimicrobial, antioxidant, antiobesity, and anticancer properties of the ligand and its 3d-metal complexes.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Environmental Sciences
P. S. Vaisakh, U. K. Adarsh, K. Amrutha, Anish Kumar Warrier, V. B. Kartha, V. K. Unnikrishnan
Summary: The increased use of plastic products and global industrial conditions have led to pollution of natural resources, especially water, with microplastics and heavy metals. Continuous monitoring of water samples is urgently needed, but current methods require complicated and separate sampling approaches. This article proposes a system that uses multi-modal LIBS-Raman spectroscopy to detect microplastics and heavy metals in water, with a unified sampling and pre-processing approach. The system can accurately detect trace elements from microplastic surfaces, such as heavy metals and other elements. It has been compared to conventional techniques and showed better results in detecting microplastic-based trace elements.
ENVIRONMENTAL RESEARCH
(2023)
Article
Optics
Lukasz A. Sterczewski, Mathieu Fradet, Clifford Frez, Siamak Forouhar, Mahmood Bagheri
Summary: Mid-wave infrared optical frequency combs (OFC) are crucial for spectroscopy applications. Quantum well diode laser (QWDL) OFC shows excellent spectral uniformity and narrow optical linewidths. The source offers a wide optical span and high repetition rate. QWDL OFCs are highly suitable for chip-based real-time sensing systems in the mid-infrared.
LASER & PHOTONICS REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Abdel Majid A. Adam, Moamen S. Refat, Ahmed Gaber, Ivo Grabchev
Summary: Adrenaline complexes with bivalent ions Mg2+, Ca2+, Sr2+ and Ba2+ in methanol at 60 degrees C were prepared and characterized. The stoichiometric reactions indicated different ratios for the complexes, with Ca2+, Sr2+ and Ba2+ having a ratio of 1:2 (M:L) and Mg2+ having a ratio of 1:1 (M:L). Spectroscopic analysis confirmed the coordination mode through the OH phenolic groups. The metal chelates of adrenaline showed higher antimicrobial activity compared to the free ligand.
BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA
(2023)
Article
Engineering, Electrical & Electronic
Xin Zhang, Zhigang Peng, Zihan Dong, Peng Yao, Yubin Hou, Pu Wang
Summary: This study demonstrated a methane-filled mid-infrared 2.8-mu m picosecond Raman laser with high average power and beam quality, presenting a promising approach for generating mid-infrared ultrafast lasers.
IEEE PHOTONICS TECHNOLOGY LETTERS
(2022)
Article
Environmental Sciences
Rohit Sharma, Teenu Jasrotia, Rajeev Kumar, Raman Kumar, Asma A. Alothman, Murefah mana AL-Anazy, Khadraa N. Alqahtani, Ahmad Umar
Summary: This study demonstrates the interactions of diverse fungal species for the removal of hazardous multi-metals from aqueous solutions through the manipulation of cell concentrations. By constructing microbial consortia, removal rates of over 95% for lead and nickel were achieved. The research also validates the relationship between biosorption capacity and efficiency of the novel consortium under different conditions.
Article
Agricultural Engineering
Arvind Singh, Dan Bahadur Pal, Akbar Mohammad, Alaa Alhazmi, Shafiul Haque, Taeho Yoon, Neha Srivastava, Vijai Kumar Gupta
Summary: Biologically based techniques offer effective and environmentally friendly solutions to wastewater contaminated with dyes and heavy metals, with ongoing advancements and potential to further revolutionize water purification applications in the future.
BIORESOURCE TECHNOLOGY
(2022)
Article
Optics
Kaixuan Wang, Chuanfei Yao, Yongjing Wu, Xuan Wang, Yunpeng Wang, Pingxue Li
Summary: In this study, the interference characteristics of HgCdTe infrared focal plane array (IRFPA) detector were investigated under irradiation from a high-repetition-rate mid-infrared supercontinuum fiber laser. The results showed that the detector's performance was sensitive to laser power, with an interference threshold of 0.043 W/cm2 and a temporary blindness threshold of 0.14 W/cm2. The interference mechanism involved both optical and thermal effects on the HgCdTe detector. These findings provide theoretical and experimental basis for photoelectric countermeasures, infrared guidance, and other related fields.
OPTICS AND LASER TECHNOLOGY
(2023)
Article
Optics
Qianwen Li, Fangyan Wang, Fei Liang, Zhongben Pan, Haohai Yu, Huaijin Zhang
Summary: In this study, we demonstrate the optimization and potential applications of thulium-doped yttrium-gallium garnet (Tm:YGG) in continuous-wave mid-infrared lasers. By adjusting the doping concentration and using birefringent filters, high-power output and continuous tunability of the lasers were achieved.
OPTICS AND LASER TECHNOLOGY
(2024)
Article
Chemistry, Analytical
Zhongyue Guo, Yeran Bai, Meng Zhang, Lu Lan, Ji-Xin Cheng
Summary: Antimicrobial resistance poses a major threat to global health and economics, necessitating rapid AST methods. We introduce a rapid AST method based on wide-field mid-infrared photothermal imaging, capable of metabolic imaging for hundreds of bacteria at single-cell resolution within seconds. This method enables probing of perturbed microbial protein synthesis within 1 hour after antibiotic treatment in E. coli cells, providing insights into antibiotic susceptibility.
ANALYTICAL CHEMISTRY
(2023)
Article
Environmental Sciences
Xi Chen, Shujat Ali, Leiming Yuan, Fengyi Guo, Guangzao Huang, Wen Shi, Xiaojing Chen
Summary: This study quantified heavy metals contaminated microplastics samples using Laser-Induced Breakdown Spectroscopy (LIBS) and determined the sources of the contaminants based on the trace metals in microplastics. The findings demonstrated that LIBS is a promising and facile technique for rapid and non-destructive multi-metals detection in individual samples, making it suitable for the characterization of microplastics and analysis of heavy metals contaminants' sources in microplastics particles.
Article
Biochemical Research Methods
Mahmoud A. Mohamed
Summary: A cost-effective and precise RP-HPLC method was developed and validated for the analysis of Alogliptin and Pioglitazone in patients with Type 2 diabetes. The method showed satisfactory results in various tests and can be used for quality control.
JOURNAL OF CHROMATOGRAPHIC SCIENCE
(2023)
Article
Pharmacology & Pharmacy
M. A. Mohamed
Summary: This study aims to develop a stable RP-HPLC method for determining the content uniformity and in-vitro dissolution of baricitinib and its degradation products in film-coated tablet dosage form. The method has been confirmed by the FDA for the efficacy and safety of baricitinib. The results show that the proposed method has good linearity, accuracy, and recovery, and can effectively determine the content and dissolution of baricitinib and its degradation products.
ANNALES PHARMACEUTIQUES FRANCAISES
(2023)
Review
Chemistry, Multidisciplinary
Mahmoud A. Mohamed, Hossam F. Nassar
Summary: Takeda has developed a tablet dosage form combining candesartan cilexetil and hydrochlorothiazide for hypertension treatment, which has recently been approved by the USFDA. The objective of this study was to optimize and develop a stable reversed-phase ultra-performance liquid chromatography method for simultaneous quantification of candesartan cilexetil and hydrochlorothiazide in tablet dosage forms, and its application in content uniformity and dissolution studies.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Medicinal
Mahmoud A. Mohamed, Mohamed El-Kassem M. Hassouna
Summary: New and upgraded HPLC and UHPLC methods were developed for simultaneous estimation of a quaternary mixture in a powder for oral suspension dosage form. These methods were applied to holding time study and proved to be accurate and efficient. Additionally, eco-friendly spectrophotometric methods were successfully developed for resolving spectral overlap.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2023)
Article
Crystallography
Abdulrahman A. Almehizia, Hamad M. Alkahtani, Mohamed A. Al-Omar, Ahmad J. Obaidullah, Mashooq A. Bhat, Lamees S. Alrasheed, Ahmed M. Naglah, Ayman A. O. Younes, Amnah Mohammed Alsuhaibani, Moamen S. Refat, Abdel Majid A. Adam, Mohamed Y. El-Sayed, Kareem A. Asla
Summary: Eight polymer-metal complexes were synthesized through complexation of divalent Mn(II), Ni(II), Co(II), and Cu(II) metal ions with modified polystyrene-alt-(maleic anhydride) (PSMAP and PSMAM) ligands. The structures of the complexes were characterized using magnetic moment susceptibility, conductance measurements, FT-IR spectroscopy, UV-VIS, TGA, and SEM. The complexes exhibited non-electrolytic behavior based on conductance measurements, and the polymer ligands acted as neutral bidentate NO ligands. The complexes showed octahedral geometry based on their electronic spectra and magnetic properties, and were more thermally stable than the ligands. SEM and TEM provided information on the surface structure and particle size of the complexes.
Article
Crystallography
Sadaf Mutahir, Muhammad Asim Khan, Ahmed M. M. Naglah, Mohamed A. A. Al-Omar, Abdulrahman A. A. Almehizia, Bader Huwaimel, Amr S. S. Abouzied, Amirah Senaitan Alharbi, Moamen S. S. Refat
Summary: One of the biggest challenges in contemporary medicine is cancer. New treatment approaches are needed due to the difficulties and prolonged nature of current therapies, as well as the increasing resistance of cancer cells. In this study, ten triazine sulfonamide derivatives were examined for their potential in cancer treatment. Through in silico docking analysis, it was found that these compounds showed promising binding affinities to receptors involved in cancer development and metastasis. In addition, ADME experiments supported the drug similarity of these compounds, and MEP calculations provided insight into their interactions.
Article
Crystallography
Sadaf Mutahir, Fakhira Yaqoob, Muhammad Asim Khan, Amnah Mohammed Alsuhaibani, Amr S. Abouzied, Moamen S. Refat, Bader Huwaimel
Summary: A new bentonite clay composite was synthesized and tested for the removal of methylene blue (MB) from wastewater. Various spectroscopic techniques were used to characterize its efficacy. The results showed that the modification significantly increased the adsorption capacity, with a maximum of 258 mg/g achieved at pH 11. The pseudo-second-order model best described the sorption process, and the Langmuir isotherm model confirmed the monolayer adsorption mechanism. This study demonstrated the potential of the bentonite-SB adsorbent for MB removal from wastewaters.
Article
Crystallography
Ayman A. O. Younes, Abdel Majid A. Adam, Moamen S. Refat, Asma S. Al-Wasidi, Abdulrahman A. Almehizia, Mohamed A. Al-Omar, Ahmed M. Naglah, Abdulrahman M. Al-Obaid, Hamad M. Alkahtani, Ahmad J. Obaidullah, Mohamed Y. El-Sayed, Kareem A. Asla
Summary: Three new transition-metal complexes were synthesized by refluxing azodicarbonamide (ADCA) with nickel(II), copper(II), and zinc(II) solutions in a mixture of 50% (v/v) methanol and water. FT-IR analysis indicated a bi-dentate chelation through the N-azo and O-carbonyl groups in all complexes. The optical band gaps of the complexes were within the range of highly effective photovoltaic materials, suggesting their potential as semiconductors.
Article
Chemistry, Analytical
Osama A. Mahmoud, Ahmed A. Omran, Ammena Y. Binsaleh, Manal A. Almalki, Mahmoud A. Mohamed
Summary: In this study, a novel and accurate RP-HPLC and RP-UPLC methods were developed for simultaneous determination of bisoprolol fumarate (BIS) and perindopril arginine (PER) in their pure, bulk, and combined tablet dosage form.
JOURNAL OF AOAC INTERNATIONAL
(2023)
Article
Chemistry, Analytical
Tahani Y. A. Alanazi, Manal A. Almalki, Mahmoud A. Mohamed, Hossam F. Nassar
Summary: Implementing Lean Six Sigma methodology and developing green analytical methods are recommended for efficiency improvement and sustainability. This study focuses on developing assessment tools for the greenness of validated RP-UPLC and MCR methods for simultaneous estimation and separation of CIP, AZI, and DIC. The methods were found to be linear and had excellent recovery rates.
MICROCHEMICAL JOURNAL
(2023)
Article
Multidisciplinary Sciences
Tahani Y. A. Alanazi, Rami Adel Pashameah, Ammena Y. Binsaleh, Mahmoud A. Mohamed, Hoda A. Ahmed, Hossam F. Nassar
Summary: A precise, environmentally friendly, and highly sensitive RP-HPLC method was developed to identify cephalexin and cefixime residues in manufacturing machines. The method utilized quality by design principles and achieved good results.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Nada S. Al-Kadhi, Mahmoud A. Mohamed, Hoda A. Ahmed, Hossam F. Nassar
Summary: Economical, highly robust, selective, precise, and eco-friendly RP-UPLC and spectrophotometric methods were developed for the concurrent estimation of ceftazidime and pyridine. Response surface methodology and mean centering of ratio spectra methods were used to optimize the chromatographic conditions and resolve spectral superposition.
Article
Engineering, Biomedical
Amany M. Abd El Azeem, Jehan Alsharnoubi, Marwa Abd El-Rahman Mohamed
Summary: This study compared the effects of laser acupuncture and the commonly used osmotic laxative lactulose on children with functional chronic constipation. The results showed that laser acupuncture can be considered as an alternative therapy for patients with this condition.
LASERS IN MEDICAL SCIENCE
(2023)
Article
Chemistry, Analytical
Osama A. Mahmoud, Ahmed A. Omran, Hosni A. Gomaa, Mahmoud A. Mohamed
Summary: This study successfully developed a high-performance liquid chromatography method for the simultaneous analysis of doxycycline hyclate and its related substances. The method has a wide range of application and provides accurate and reliable results. It has been successfully used for comparative studies of drugs and demonstrated the similarity between two products.
SEPARATION SCIENCE PLUS
(2023)
Article
Chemistry, Multidisciplinary
Samar M. Mahgoub, M. Ramadan Mahmoud, Ammena Y. Binsaleh, Manal A. Almalki, Mahmoud A. Mohamed, Hossam F. Nassar
Summary: This study aims to find eco-friendly solutions to replace harmful substances and reduce waste production in the analytical process. A newly validated RP-HPLC technique was used to quantitatively determine levodopa and carbidopa drugs, while incorporating the lean six sigma methodology for accuracy and efficiency. The results show that the developed method is accurate and valid, with good adherence to green chemistry principles.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Article
Chemistry, Physical
Xinlei Chen, Shiyi Chen, Xuele Lin, Jingxuan Zhou, Xingjun Gao, Yaoqi Zhen, Xiaodan Ma, Shouwen Jin, Linfang Shi, Hui Liu, Daqi Wang
Summary: Nine mixed-ligand Cd2+ complexes with different geometric structures were synthesized and characterized. The complexes exhibit various coordination modes and form both intra- and intermolecular hydrogen bonds.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Rupali Mahajan, Abhishek Sharma, Bhagyashree Patra, Lijo Mani, Parul Grover, Sandeep Kumar, Santosh Kumar Guru, Gananadhamu Samanthula, Amol G. Dikundwar, Amit Asthana
Summary: This research article provides a comprehensive characterization and toxicological assessment of a photoisomeric impurity of the antianemic drug Roxadustat. The impurity has a distinct structure compared to the drug and its formation due to light exposure is a concern. Through various experiments, including single crystal XRD, physicochemical characterization, and in vitro cytotoxicity assays, the researchers confirmed the structure of the impurity, evaluated its conversion with Roxadustat, and assessed its toxicological activity. These findings contribute to the understanding of drug stability, safety, and formulation development.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Laila S. Alqarni, Azzah M. Alghamdi, Nuha Y. Elamin, A. Rajeh
Summary: The solution casting method was used to produce a new type of nanocomposites made of chitosan, gelatin, and co-doped ZnO nanoparticles. The addition of 3.5% co-doped ZnO nanoparticles improved the physicochemical characteristics and antimicrobial effects of the nanocomposites, indicating their significant potential in food packaging and energy storage.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Ruchi Gaur
Summary: The structure and intermolecular interactions of a newly synthesized bis-chalcone THXA were studied using experimental and computational methods. The importance of non-covalent interactions such as pi center dot center dot center dot pi, C-H center dot center dot center dot S, and C-H center dot center dot center dot pi was revealed.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Andrii Bazylevich, Leonid Patsenker, Sarit Aviel-Ronen, Gary Gellerman
Summary: Drug combination therapy is commonly used for treating various skin disorders, but its effectiveness is often limited. In this study, researchers synthesized conjugates of anti-pigmenting drugs and hyaluronic acid (HA) to improve treatment efficacy. These HA-drug conjugates exhibited measurable drug release profiles and demonstrated superior depigmentation effects compared to control groups in a swine model.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Xiaodan Ma, Xinlei Chen, Yaoqi Zhen, Xunjie Zheng, Chengzhe Shi, Shouwen Jin, Bin Liu, Bin Chen, Daqi Wang
Summary: Cocrystallization experiments between minoxidil and aryl acids coformers resulted in the successful formation of multi-component samples. The nature of these samples was determined using various techniques and their structural and supramolecular aspects were investigated. The outcomes revealed the importance of nonbonding contacts and different types of interactions in stabilizing and expanding the crystal structures.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Najla A. Alshaye, Magdy A. Ibrahim, Al-Shimaa Badran
Summary: The chemical behavior of 3-substituted-6,8-dimethylchromones towards phenylhydrazine was examined. Different reaction conditions produced various products, and the molecular geometries and reactivity descriptors of the compounds were also investigated. The results suggest that these compounds are suitable for nonlinear optical applications.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Hayette Alliouche, Houria Bouria, Rafik Bensegueni, Mounia Guergouri, Abdelmalek Bouraiou, Ali Belfaitah
Summary: In this paper, a combined experimental and theoretical study was conducted to synthesize and characterize new 2-quinolone-piperidine and -morpholine hybrids. The results from experiments were validated using computational calculations, and the affinity between these compounds and Acetylcholinesterase/Butyrylcholinesterase was estimated through molecular docking.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Wei-Min Chen, Juan-Juan Shao, Yi Zhang, Zhen-Dong Xue, Peng-Lai Liu, Jian-Ling Ni, Li-Zhuang Chen, Qiang Gao, Fang-Ming Wang
Summary: This study synthesized and characterized a novel Mn-based LMOF, and achieved good results in detecting heavy metal Al3+ in water, showing good stability, high selectivity and sensitivity. This provides new insights into the potential applications of Mn-based MOFs in chemical sensing.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Jun-Xia Li, Yi-Jing Lu, Ke-Ying Quan, Li-Bing Wu, Xun Feng, Wei-Zhou Wang
Summary: This study synthesized two cobalt(II) complexes and analyzed their crystal structures using single-crystal X-ray diffraction. The results showed that the crystal structures of these complexes were different, and they exhibited different crystal packing and magnetic properties.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Yang Li, Yan Zhang, Hong Xu, Min Li, Zhen Li, Zi-yu Song, Ji-shi Chen, Yan-Jun Liu, Yong Sun, Zhao Yang
Summary: This study reports the synthesis and solid-state characterization of a new pharmaceutical cocrystal, PRO-BPE, which can enhance the solubility of the highly water-insoluble prodrug probenecid. The PRO-BPE cocrystals were found to have superior water solubility compared to pure PRO. This research provides valuable insights into improving the solubility of poorly soluble drugs.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Lucas G. B. Felicio, Bianca B. M. Vieira, Ivana S. Lula, Renata Diniz, Frank Alexis, Flavio B. Miguz, Frederico B. De Sousa
Summary: A novel spiropyran derivative was synthesized for heavy metals sensing in water. The results demonstrated that the new derivative can serve as a rapid, sensitive, and simple tool for detecting Hg2+ ions in water with high selectivity.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Junqing Meng, Jie Wang, Lijuan Wang, Chunhui Lyu, Haiyan Chen, Yingpei Lyu, Baisheng Nie
Summary: Material modification with low surface energy can achieve lower surface free energy on micro-and nano-rough structures, which is crucial for developing superhydrophobic surfaces. In this study, attapulgite (APT) was modified with alkylamine, alkylammonium salt, and stearic acid, and the interaction between low surface materials and attapulgite was explained. The results showed that the hydrophobicity of APT was significantly modified by the modifiers, and the surface free energy of the composites first decreased and then increased with increasing molecular number of low surface energy monomers.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Karan Goswami, Dipak Das, Parthasarathi Bera, Sounak Roy, Md. Motin Seikh, Prasanta Kumar Sinha, Arup Gayen
Summary: This work presents the development of a simple and highly active heterogeneous Pd catalyst for Suzuki-Miyaura carbon-carbon cross-coupling reaction. The NiPdFe-1 catalyst shows the best activity and stability among the prepared catalysts. It efficiently promotes the coupling reaction between aryl bromide and phenyl boronic acid under mild reaction conditions with high isolated yields.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Ekta Pardhi, Devendra Singh Tomar, Rahul Khemchandani, Gananadhamu Samanthula, Pankaj Kumar Singh, Neelesh Kumar Mehra
Summary: The main aim of this study was to prepare a drug-drug coamorphous system to improve the physiochemical properties, solubility and stability of Apremilast and Indomethacin. Various solid-state characterization techniques were used to characterize the prepared system. Molecular level interactions were studied using molecular modeling and ATR-FTIR and 1H NMR. Solubility and dissolution studies showed the benefits of the coamorphous system. The system was found to be stable for a period of five months. Permeation study also demonstrated improved flux for both drugs compared to their crystalline forms. The coamorphous system showed anti-psoriatic and anti-melanogenic activity based on molecular docking results. Overall, the developed CAM-based supersaturated system exhibited improved physicochemical properties and physical stability.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
