Increased Plasma Concentrations of Unbound SN-38, the Active Metabolite of Irinotecan, in Cancer Patients with Severe Renal Failure

Title
Increased Plasma Concentrations of Unbound SN-38, the Active Metabolite of Irinotecan, in Cancer Patients with Severe Renal Failure
Authors
Keywords
PBPK model, protein binding, severe renal dysfunction, SN-38, unbound concentration
Journal
PHARMACEUTICAL RESEARCH
Volume 33, Issue 2, Pages 269-282
Publisher
Springer Nature
Online
2015-09-04
DOI
10.1007/s11095-015-1785-0

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