Article
Dermatology
S. Atilla, O. Gokoz, S. Ozer, G. Elcin
Summary: The study aimed to assess the concordance between Mohs surgeon and pathologist in evaluating Mohs slides, showing a high concordance rate and good inter-rater agreement.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Dermatology
Frances Walocko, Priya Chelliah, Elysha Kolitz, Jessica Awerman, Rajiv I. Nijhawan, Divya Srivastava
Summary: The study found that a significant proportion of BCC patients are underestimated on initial biopsy and could benefit from more definitive intervention such as MMS. Tumors with upgraded pathology often require more stages of surgery, larger pre-operative and post-operative sizes, advanced repairs, and may be referred for post-operative radiation.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Article
Surgery
Iliana Aristokleous, Inkeri Schultz, Ismini Vassilaki, Britta Krynitz, Jan Lapins, Ada Girnita, Margareta Frohm Nilsson
Summary: Mohs micrographic surgery is the preferred surgical option for high-risk basal cell carcinomas. Interdisciplinary collaboration can be effective in patient selection and performing all steps of the procedure, resulting in low recurrence rates.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Article
Dermatology
C. Natterdahl, J. Kappelin, B. Persson, K. Lundqvist, I Ahnlide, K. Saleh, A. Ingvar
Summary: Older age, previous cryotherapy, and multiple prior surgeries were significantly associated with an increased risk of MMS requiring >= 3 stages. Recurrent BCC was associated with the risk of complicated MMS in partially adjusted multivariate analyses, but not in the fully adjusted analyses. Knowledge of these risk factors may help improve the planning of Mohs surgeries.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Dermatology
Nianzhou Yu, Lisha Wu, Juan Su, Mingliang Chen, Lixia Lu, Kai Huang, Yixin Li, Zixi Jiang, Siliang Liu, Lanyuan Peng, Yang Xie, Zeyu Chen, Wenhu Zhou, Miaojian Wan, Fang Fang, WenBo Bu, Shuang Zhao
Summary: This study compared the efficacy and safety of photodynamic therapy combined with surgery (S-PDT) and Mohs micrographic surgery (MMS) for the treatment of difficult-to-treat basal cell carcinoma (BCC). The results showed no statistical difference in recurrence rate between the two treatment methods, but S-PDT had a longer healing time and no significant difference in cosmetic outcome compared to MMS. In conclusion, S-PDT is a safe and effective alternative treatment to MMS for certain cases.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2023)
Article
Dermatology
William T. N. Hunt, Toby G. Nelson
Summary: By surveying international Mohs surgeons, this study aims to characterize variation in margin threshold assessment, surgeon background characteristics, and tissue processing and intraoperative approaches.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Article
Dermatology
Mike C. M. van Zon, Jose D. van der Waa, Mitko Veta, Gertruud A. M. Krekels
Summary: The study showed that deep learning models based on whole-slide images can be a feasible option to improve the clinical workflow and reduce costs in histological analysis of BCC in MMS.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Dermatology
Geoffrey Fung-Soon Lim, Oliver A. Perez, John A. Zitelli, David G. Brodland
Summary: This study aimed to investigate the subclinical extension tendency between different histologic subtypes of basal cell carcinoma (BCC). The study found that the subclinical extension tendency of superficial BCC is similar to aggressive subtypes of BCC. Additionally, when histologic subtype drift occurs, superficial BCC is the most likely subtype to extend subclinically.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Rumsha Salman, Caroline Daly, Advika Dani, Amarachi Eseonu, Kristin Bibee, Jeffrey F. Scott
Summary: This study retrospectively analyzed the medical records of patients undergoing Mohs micrographic surgery for keratinocyte carcinoma between July 1, 2019 and February 28, 2021 to investigate the impact of time to treatment (TTT) on surgical characteristics. The study found that increasing TTT was not associated with an increased utilization of flap or graft repairs. Although a 42-day increase in TTT was linked to an increase in the post-operative surgical defect size, TTT was not associated with repair length or flap/graft repair area. In conclusion, TTT did not independently influence the complexity of Mohs reconstruction within the studied time range.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Dermatology
Antonio Castanheira, Paula Boaventura, Paula Soares, Fortunato Vieira, Jose Manuel Lopes, Alberto Mota
Summary: This paper highlights the most important aspects of Mohs micrographic surgery (MMS) and its outcomes in ENT surgeons' daily practice.
DERMATOLOGIC THERAPY
(2021)
Article
Dermatology
Hannah Ceder, Malin Gronberg, John Paoli
Summary: This retrospective study compared primary and recurrent facial high-risk basal cell carcinomas treated with Mohs micrographic surgery. Primary tumors required fewer surgery stages, had smaller final defect sizes, and were more often reconstructed by primary closure compared to recurrent or incompletely excised tumors. Improved adherence to Mohs micrographic surgery indications for primary tumors could lead to better resource utilization and patient outcomes.
ACTA DERMATO-VENEREOLOGICA
(2021)
Article
Surgery
Constantinos Kokkinos, Muholan Kanapathy, Soroush Heydari, Stephen Hamilton, Simon Withey
Summary: This study investigated the waiting time for MMS in BCC patients and the change in lesion size during this period. The findings suggest that a longer wait time before MMS may lead to an increase in lesion size, and treating with SE could affect the final defect size.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Review
Dermatology
Aamir Hussain, Emily Y. Kim, Amor Khachemoune
Summary: Mohs micrographic surgery (MMS) is an effective treatment for oral cavity cancers, particularly squamous cell carcinomas. It allows for better visualization of tumor margins and preservation of benign tissue. However, its applicability is limited by the surgeon's comfort with the technique and interpretation of specimens.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Medicine, General & Internal
Blake St Clair, Abigale Clark, Benjamin Rollins, Thomas A. Jennings
Summary: This study retrospectively reviewed the experience of using Mohs micrographic surgery (MMS) to treat DFSP at an academic institution, and provided valuable examples for closure techniques of large surgical defects on the forehead and sternum. The results of the study showed that MMS is an effective treatment for DFSP with no recurrence in patients.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Ali Asilian, Reza Moeine, Hossein Hafezi, Reza Shahriarirad
Summary: Vulvar Basal Cell Carcinoma is a rare type of BCC, presenting as a pinkish lesion and persistent pruritus in the vulvar area. It can be successfully treated with Mohs micrographic Surgery.
CLINICAL CASE REPORTS
(2022)
Letter
Allergy
Maeve M. Kelleher, Suzie Cro, Rachel Phillips, Hywel C. Williams, Adrian J. Lowe, Robert J. Boyle
Editorial Material
Dermatology
H. C. Williams
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Editorial Material
Dermatology
H. C. Williams
Summary: This article discusses the issue of research waste in dermatology and proposes possible solutions, mainly focusing on clinical trials and citing examples from the Center of Evidence-Based Dermatology (CEBD) and other research groups.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Primary Health Care
Eileen Sutton, Alison R. G. Shaw, Matthew J. Ridd, Miriam Santer, Amanda Roberts, Helen Baxter, Hywel C. Williams, Jonathan Banks
Summary: This study aimed to understand how parents and children experience and evaluate emollients. The findings suggest that there is no one-size-fits-all emollient and parents/children prioritize different aspects of emollients. Some participants reported that participating in the trial had changed their knowledge and behavior regarding emollients.
BRITISH JOURNAL OF GENERAL PRACTICE
(2022)
Article
Allergy
Hilary I. Allen, Ursula Pendower, Miriam Santer, Marion Groetch, Mitchell Cohen, Simon H. Murch, Hywel C. Williams, Daniel Munblit, Yitzhak Katz, Neeraj Gupta, Sabeen Adil, Justine Baines, Eefje G. P. M. de Bont, Matthew Ridd, Victoria L. Sibson, Alison McFadden, Jennifer J. Koplin, Josephine Munene, Michael R. Perkin, Scott H. Sicherer, Robert J. Boyle
Summary: This study investigates the issue of overdiagnosis of milk allergy and provides recommendations from non-conflicted experts to reduce overdiagnosis and support children with suspected milk allergy. The new recommendations suggest stricter diagnostic criteria, more support for breastfeeding, and less use of specialized formula.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Letter
Dermatology
Lloyd Steele, Ilia A. Petrou, Hywel C. Williams
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Shoba Dawson, Katie Banister, Katie Biggs, Seonaidh Cotton, Declane Devane, Heidi Gardner, Katie Gillies, Gosala Gopalakrishnan, Talia Isaacs, Kamlesh Khunti, Alistair Nichol, Adwoa Parker, Amy M. Russell, Victoria Shepherd, Frances Shiely, Gillian Shorter, Bella Starling, Hywel Williams, Andrew Willis, Miles D. Witham, Shaun Treweek
Summary: This article introduces the UK National Institute for Health and Care Research's (NIHR) "INCLUDE" project, which identified under-served groups in trials, including ethnic minorities. It provides four key recommendations for designing and running trials that include these ethnic groups.
Letter
Dermatology
Laura Adams, Georgina Nakafero, Matthew J. Grainge, Tim Card, Christian D. Mallen, Jonathan S. Nguyen Van-Tam, Hywel C. Williams, Abhishek Abhishek
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Dermatology
Lloyd Steele, Xiang Li Tan, Bayanne Olabi, Jing Mia Gao, Reiko J. J. Tanaka, Hywel C. C. Williams
Summary: Machine learning models for skin cancer recognition have varying performance across different skin phototypes and skin cancer types. Our study aims to assess whether studies have reported results separately for different skin phototypes and rarer skin cancers, and to graphically represent the skin cancer training datasets used by current ML models.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Stephanie J. Lax, Amanda Roberts, Eleanor Cliffe, Grishma Ramesh, Dija Ayodele, Hywel C. Williams, Sharon Belmo, Paul Leighton
Summary: Our study found that the Fitzpatrick Scale fails to accurately reflect how individuals perceive their own skin tone. Respondents provided diverse descriptions of their skin tone, with some acknowledging the impact of social inequalities on their language choices. In order to create comprehensive and inclusive tools, it is crucial to incorporate the perspectives of patients.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Dermatology
Carolyn Charman, Hannah Wainman, Aswatha Rabindranathnambi, Chin Whybrew, Hywel C. Williams
Summary: The COVID-19 pandemic has accelerated the rapid expansion of digital Advice and Guidance (A&G) in medical and surgical specialties in the UK, particularly in dermatology. Limited guidance exists on what constitutes a high-quality A&G request and response. This educational article discusses good clinical practice based on extensive experience from primary and secondary care doctors.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Review
Dermatology
Sophie Leducq, Natalie Bonsu, Kate Clement, Richard Barlow, Hywel C. Williams
Summary: This educational review defines predatory journals and conferences, highlights their distinguishing features, and summarizes the consequences of publishing in or attending them. It also outlines tools available to recognize and avoid predation.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Review
Dermatology
John Frewen, Marianne de Brito, Anjali Pathak, Richard Barlow, Hywel C. Williams
Summary: The number of published systematic reviews has increased rapidly, but the quality of most dermatology systematic reviews is not satisfactory. To help busy clinicians evaluate study quality and clinical utility, we provide a set of useful tips including assessing motivation, checking for a prepublished study protocol, using PRISMA and AMSTAR 2 checklists, evaluating spin, and summarizing the strengths and limitations of the study. Having a set of heuristics saves time and allows for structured assessment, leading to prompt conclusions about the merits of a review article for dermatology patient care.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Dermatology
Yael A. Leshem, Eric L. Simpson, Christian Apfelbacher, Phyllis Spuls, Kim S. Thomas, Jochen Schmitt, Laura Howells, Louise A. A. Gerbens, Michael E. Jacobson, Norito Katoh, Hywel C. Williams
Summary: This article provides a practical guide for implementing Core Outcome Sets (COS) in clinical trials to improve the consistency of outcome measurement and reporting. The implementation roadmap offered in this study can enhance the quality and applicability of research.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Medical Informatics
O. T. Jones, R. N. Matin, M. van der Schaar, K. Prathivadi Bhayankaram, C. K. Ranmuthu, M. S. Islam, D. Behiyat, R. Boscott, N. Calanzani, J. Emery, H. C. Williams, F. M. Walter
Summary: This study systematically reviews the use of artificial intelligence and machine learning algorithms for the early diagnosis of skin cancers. The results show reasonable diagnostic accuracy for melanoma, squamous cell carcinoma, and basal cell carcinoma, but there is heterogeneity in the methods and study designs, with incomplete reporting in some studies. The widespread adoption into community and primary care practice cannot currently be recommended until efficacy in low prevalence populations is demonstrated.
LANCET DIGITAL HEALTH
(2022)
Article
Chemistry, Physical
Xinlei Chen, Shiyi Chen, Xuele Lin, Jingxuan Zhou, Xingjun Gao, Yaoqi Zhen, Xiaodan Ma, Shouwen Jin, Linfang Shi, Hui Liu, Daqi Wang
Summary: Nine mixed-ligand Cd2+ complexes with different geometric structures were synthesized and characterized. The complexes exhibit various coordination modes and form both intra- and intermolecular hydrogen bonds.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Rupali Mahajan, Abhishek Sharma, Bhagyashree Patra, Lijo Mani, Parul Grover, Sandeep Kumar, Santosh Kumar Guru, Gananadhamu Samanthula, Amol G. Dikundwar, Amit Asthana
Summary: This research article provides a comprehensive characterization and toxicological assessment of a photoisomeric impurity of the antianemic drug Roxadustat. The impurity has a distinct structure compared to the drug and its formation due to light exposure is a concern. Through various experiments, including single crystal XRD, physicochemical characterization, and in vitro cytotoxicity assays, the researchers confirmed the structure of the impurity, evaluated its conversion with Roxadustat, and assessed its toxicological activity. These findings contribute to the understanding of drug stability, safety, and formulation development.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Laila S. Alqarni, Azzah M. Alghamdi, Nuha Y. Elamin, A. Rajeh
Summary: The solution casting method was used to produce a new type of nanocomposites made of chitosan, gelatin, and co-doped ZnO nanoparticles. The addition of 3.5% co-doped ZnO nanoparticles improved the physicochemical characteristics and antimicrobial effects of the nanocomposites, indicating their significant potential in food packaging and energy storage.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Ruchi Gaur
Summary: The structure and intermolecular interactions of a newly synthesized bis-chalcone THXA were studied using experimental and computational methods. The importance of non-covalent interactions such as pi center dot center dot center dot pi, C-H center dot center dot center dot S, and C-H center dot center dot center dot pi was revealed.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Andrii Bazylevich, Leonid Patsenker, Sarit Aviel-Ronen, Gary Gellerman
Summary: Drug combination therapy is commonly used for treating various skin disorders, but its effectiveness is often limited. In this study, researchers synthesized conjugates of anti-pigmenting drugs and hyaluronic acid (HA) to improve treatment efficacy. These HA-drug conjugates exhibited measurable drug release profiles and demonstrated superior depigmentation effects compared to control groups in a swine model.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Xiaodan Ma, Xinlei Chen, Yaoqi Zhen, Xunjie Zheng, Chengzhe Shi, Shouwen Jin, Bin Liu, Bin Chen, Daqi Wang
Summary: Cocrystallization experiments between minoxidil and aryl acids coformers resulted in the successful formation of multi-component samples. The nature of these samples was determined using various techniques and their structural and supramolecular aspects were investigated. The outcomes revealed the importance of nonbonding contacts and different types of interactions in stabilizing and expanding the crystal structures.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Najla A. Alshaye, Magdy A. Ibrahim, Al-Shimaa Badran
Summary: The chemical behavior of 3-substituted-6,8-dimethylchromones towards phenylhydrazine was examined. Different reaction conditions produced various products, and the molecular geometries and reactivity descriptors of the compounds were also investigated. The results suggest that these compounds are suitable for nonlinear optical applications.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Hayette Alliouche, Houria Bouria, Rafik Bensegueni, Mounia Guergouri, Abdelmalek Bouraiou, Ali Belfaitah
Summary: In this paper, a combined experimental and theoretical study was conducted to synthesize and characterize new 2-quinolone-piperidine and -morpholine hybrids. The results from experiments were validated using computational calculations, and the affinity between these compounds and Acetylcholinesterase/Butyrylcholinesterase was estimated through molecular docking.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Wei-Min Chen, Juan-Juan Shao, Yi Zhang, Zhen-Dong Xue, Peng-Lai Liu, Jian-Ling Ni, Li-Zhuang Chen, Qiang Gao, Fang-Ming Wang
Summary: This study synthesized and characterized a novel Mn-based LMOF, and achieved good results in detecting heavy metal Al3+ in water, showing good stability, high selectivity and sensitivity. This provides new insights into the potential applications of Mn-based MOFs in chemical sensing.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Jun-Xia Li, Yi-Jing Lu, Ke-Ying Quan, Li-Bing Wu, Xun Feng, Wei-Zhou Wang
Summary: This study synthesized two cobalt(II) complexes and analyzed their crystal structures using single-crystal X-ray diffraction. The results showed that the crystal structures of these complexes were different, and they exhibited different crystal packing and magnetic properties.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Yang Li, Yan Zhang, Hong Xu, Min Li, Zhen Li, Zi-yu Song, Ji-shi Chen, Yan-Jun Liu, Yong Sun, Zhao Yang
Summary: This study reports the synthesis and solid-state characterization of a new pharmaceutical cocrystal, PRO-BPE, which can enhance the solubility of the highly water-insoluble prodrug probenecid. The PRO-BPE cocrystals were found to have superior water solubility compared to pure PRO. This research provides valuable insights into improving the solubility of poorly soluble drugs.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Lucas G. B. Felicio, Bianca B. M. Vieira, Ivana S. Lula, Renata Diniz, Frank Alexis, Flavio B. Miguz, Frederico B. De Sousa
Summary: A novel spiropyran derivative was synthesized for heavy metals sensing in water. The results demonstrated that the new derivative can serve as a rapid, sensitive, and simple tool for detecting Hg2+ ions in water with high selectivity.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Junqing Meng, Jie Wang, Lijuan Wang, Chunhui Lyu, Haiyan Chen, Yingpei Lyu, Baisheng Nie
Summary: Material modification with low surface energy can achieve lower surface free energy on micro-and nano-rough structures, which is crucial for developing superhydrophobic surfaces. In this study, attapulgite (APT) was modified with alkylamine, alkylammonium salt, and stearic acid, and the interaction between low surface materials and attapulgite was explained. The results showed that the hydrophobicity of APT was significantly modified by the modifiers, and the surface free energy of the composites first decreased and then increased with increasing molecular number of low surface energy monomers.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Karan Goswami, Dipak Das, Parthasarathi Bera, Sounak Roy, Md. Motin Seikh, Prasanta Kumar Sinha, Arup Gayen
Summary: This work presents the development of a simple and highly active heterogeneous Pd catalyst for Suzuki-Miyaura carbon-carbon cross-coupling reaction. The NiPdFe-1 catalyst shows the best activity and stability among the prepared catalysts. It efficiently promotes the coupling reaction between aryl bromide and phenyl boronic acid under mild reaction conditions with high isolated yields.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Ekta Pardhi, Devendra Singh Tomar, Rahul Khemchandani, Gananadhamu Samanthula, Pankaj Kumar Singh, Neelesh Kumar Mehra
Summary: The main aim of this study was to prepare a drug-drug coamorphous system to improve the physiochemical properties, solubility and stability of Apremilast and Indomethacin. Various solid-state characterization techniques were used to characterize the prepared system. Molecular level interactions were studied using molecular modeling and ATR-FTIR and 1H NMR. Solubility and dissolution studies showed the benefits of the coamorphous system. The system was found to be stable for a period of five months. Permeation study also demonstrated improved flux for both drugs compared to their crystalline forms. The coamorphous system showed anti-psoriatic and anti-melanogenic activity based on molecular docking results. Overall, the developed CAM-based supersaturated system exhibited improved physicochemical properties and physical stability.
JOURNAL OF MOLECULAR STRUCTURE
(2024)