Article
Chemistry, Inorganic & Nuclear
Marco Meyer, Lorenzo Mardegan, Daniel Tordera, Alessandro Prescimone, Michele Sessolo, Henk J. Bolink, Edwin C. Constable, Catherine E. Housecroft
Summary: The synthesis and characterisation of a series of heteroleptic copper(I) compounds with different anions were reported. The effects of the counterion on packing interactions in the solid state and photophysical properties were investigated. The compounds were also used in electroluminescent materials, with different counterions showing varying levels of performance in light-emitting electrochemical cells.
DALTON TRANSACTIONS
(2021)
Article
Multidisciplinary Sciences
Mohammad Mahdi Doroodmand, Sina Owji
Summary: A novel electrosynthetic method utilizing layer-by-layer self-assembly of Salen-based nanowires has been developed as a capacitive pseudo-supercapacitor. The polymer synthesized using this method exhibited high stability and capacity performance during charge/discharge cycling.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Inorganic & Nuclear
Xiaolin Zhu, Hongya Miao, Yong Shan, Guangyuan Gao, Quan Gu, Qi Xiao, Xiaoming He
Summary: This study reports a novel strategy for the preparation of a 2D Janus film with self-assembled gold nanoparticles, which exhibits promising photocatalytic H-2 evolution activity.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Rishav Chatterjee, Indira Bhattacharya, Souryadip Roy, Kallol Purkait, Tuhin Subhra Koley, Arnab Gupta, Arindam Mukherjee
Summary: The study investigated N,O-donor ligands with and without pendant morpholine units in metal complexes, finding that these complexes showed excellent in vitro antiproliferative activity under specific conditions, but the presence of pendant morpholine did not enhance the efficacy of the dose. Furthermore, cells treated with the complexes exhibited antiproliferative activity, but favored a necrotic pathway of cell killing.
INORGANIC CHEMISTRY
(2021)
Article
Polymer Science
Fatima Ezzahra Bouharras, Salima Atlas, Simone Capaccioli, Massimiliano Labardi, Abdelghani Hajlane, Bruno Ameduri, Mustapha Raihane
Summary: Core-double-shell-structured nanocomposite films consisting of PVDF-g-BT incorporated into a P(VDF-co-HFP) copolymer matrix were prepared for energy storage applications. The addition of PVDF-g-BT improved the thermal stability and crystallinity of the films. The films exhibited three dielectric processes, and mechanical analysis confirmed the uniform distribution and strong interaction of PVDF-g-BT with the copolymer matrix. The suggested system shows promise for high-energy-density storage devices such as supercapacitors.
Article
Chemistry, Organic
Hui Wang, Hongchi Zhao, Shuang Chen, Libin Bai, Zhiyi Su, Yonggang Wu
Summary: Symmetric ladder-type oligo(p-aniline)s and poly(p-aniline)s were successfully synthesized by an intramolecular ring closure in a highly efficient SNAr reaction from oligo(p-phenylene)s and poly(p-phenylene)s with fluorine (F) and secondary amine (NH) groups. Unlike Cadogan ring closure, the newly designed cyclization reaction will not produce a mixture of symmetric and nonsymmetric structures. Moreover, the introduction of the F atom does not hinder Suzuki polymerization, indicating the possibility of preparing regular oligomers and polymers with a nitrogen bridge.
Article
Chemistry, Inorganic & Nuclear
Amanda Grass, Lakshani Wathsala Kulathungage, Duleeka Wannipurage, Maryam Yousif, Cassandra L. Ward, Stanislav Groysman
Summary: The synthesis and characterization of a rare homoleptic thallium alkoxide complex, Tl-2((OCBu2Ph)-Bu-t)(2), is presented. This complex serves as a precursor for the formation of various metal alkoxide complexes, including a T-shaped Zn((OCBu2Ph)-Bu-t)(2)(THF) complex. Additionally, the reaction of Tl-2((OCBu2Ph)-Bu-t)(2) with [Ru(cymene)Cl-2](2) results in the formation of a ruthenium(ii) alkoxide complex.
DALTON TRANSACTIONS
(2021)
Article
Multidisciplinary Sciences
Peiyun Li, Junwei Shi, Yuqiu Lei, Zhen Huang, Ting Lei
Summary: Research shows that by engineering the doped states of polymers, p-type polymers can be converted to high-performance n-type materials, enabling the fabrication of high-performance n-type organic electrochemical transistors (OECTs). This finding is of great significance for improving OECT performance.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Dong-Nan Yu, Zi-Xuan Yao, Fahime Bigdeli, Xue-Mei Gao, Xun Cheng, Jing-Zhe Li, Jing-Wen Zhang, Wei Wang, Zong-Jie Guan, Yongfeng Bu, Kuan-Guan Liu, Ali Morsali
Summary: The first mixed-valence nanocluster CuI/CuII with the highest percentage of CuII ions was synthesized. It exhibits strong photothermal conversion ability and broad light absorption range.
INORGANIC CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Tushita Mukhopadhyaya, Taein Lee, Connor Ganley, Paulette Clancy, Howard E. Katz
Summary: The doping mechanism of Lewis acids like B(C6F5)(3) on polymer semiconductors is still not fully understood. In this study, we investigated the doping ability of 1:1 zwitterionic complexes of B(C6F5)(3) with conjugated molecules and established their potential as doping sites for polymer semiconductors. The adduct complexes were characterized using various techniques and their doping abilities were confirmed through conductivity measurements.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Inorganic & Nuclear
Mikhail Yu. Afonin, Anastasiia Yu. Konokhova, Alexey A. Dmitriev, Pavel A. Abramov, Natalia V. Kuratieva, Taisiya S. Sukhikh, Nikolay B. Kompankov, Nina P. Gritsan, Sergey N. Konchenko
Summary: Heterometallic complexes [Cp*(2)Ln(& mu;-(CO)-C- iso )(2){Cr-2(& mu;-P)Cp-2(CO)(2)}] [Ln = Yb (1), Sm (2)] and [Cp*Y-2(& mu;-(CO)-C- iso )(2){Cr-2(& mu;-P)Cp-2(CO)(2)}] (3) were synthesized. The structures of these complexes were determined through single-crystal X-ray diffraction analysis. The P-31 NMR spectra of these complexes show high downfield chemical shifts due to the anisotropic effect of the Cr P double bonds.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Thomas Bathe, Chuan-Ding Dong, Stefan Schumacher
Summary: This theoretical study explores double molecular doping in an organic semiconductor system, demonstrating double integer charge transfer and the formation of polarons. The analysis based on DFT calculations reveals that the infrared absorption spectrum of the complex can be traced back to the individual dopant and OSC molecules, and the optical absorption spectrum shows features of both intramolecular polaron excitations and intermolecular charge transfer excitations.
JOURNAL OF PHYSICAL CHEMISTRY A
(2022)
Article
Chemistry, Multidisciplinary
Ross J. Taylor, Mauricio Aguilar Rangel, Michael B. Geeson, Pietro Sormanni, Michele Vendruscolo, Goncalo J. L. Bernardes
Summary: Post-translational protein-protein conjugation allows for the production of bioconjugates that are not achievable through genetic fusion. This study describes a method using x-clamp-mediated cysteine arylation with pentafluorophenyl sulfonamide functional groups to prepare protein-protein conjugates. By computationally designing antibodies targeting the SARS-CoV-2 receptor binding domain and using the pi-clamp sequence, dimerization was achieved, resulting in a significant increase in binding. This strategy enables the construction of molecule-protein-protein conjugates with precise chemical control over the modification sites.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Zi-Xi Li, Zhen-Zhou Sun, Guo Wang, Wei Yang, Hong-Liang Han, Yu-Ping Yang, Zhong-Feng Li, Lixiong Dai, Yi-Shan Yao, Qiong-Hua Jin
Summary: A series of ionic mononuclear Cu(I) complexes have been synthesized and characterized, and their supramolecular structures and photophysical properties were investigated. The emission wavelengths of these complexes varied due to the regulation of ligands and anions. The luminescence is derived from metal-to-ligand charge transfer excited states, and the stabilization of the ligand-based pi* orbital conjugation is responsible for the observed bathochromic-shift in the charge transfer transitions.
Article
Chemistry, Multidisciplinary
Yuto Shima, Takashi Suzuki, Hitoshi Abe, Tatsuo Yajima, Seiji Mori, Yuichi Shimazaki
Summary: Cu complexes with p-dimethylaminophenolate ligands were synthesized and characterized in this study. The complexes exhibited a valence state change from Cu-II-phenolate to Cu-I-phenoxyl radical upon loss of the coordinated solvent. The Cu-I-phenoxyl radical species showed characteristic properties and reactivities.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Applied
M. A. Diab, Gehad G. Mohamed, W. H. Mahmoud, A. Z. El-Sonbati, Sh. M. Morgan, S. Y. Abbas
APPLIED ORGANOMETALLIC CHEMISTRY
(2019)
Article
Chemistry, Applied
M. A. Diab, S. G. Nozha, A. Z. El-Sonbati, M. A. El-Mogazy, Sh. M. Morgan
APPLIED ORGANOMETALLIC CHEMISTRY
(2019)
Article
Chemistry, Physical
Elsayed Elbayoumy, Yuting Wang, Jamil Rahman, Claudio Trombini, Masayoshi Bando, Zhiyi Song, Mostafa A. Diab, Farid S. Mohamed, Naofumi Naga, Tamaki Nakano
Summary: Four vinyl polymer gels were synthesized and used as supports for palladium nanoparticles, which were applied in the oxidation reaction of benzyl alcohol. The catalytic activity and selectivity varied depending on the structure of the gels and the weight percentage loading of Pd-0, and the catalysts were stable and reusable for multiple cycles.
Article
Chemistry, Physical
S. G. Nozha, Sh M. Morgan, S. E. Abu Ahmed, M. A. El-Mogazy, M. A. Diab, A. Z. El-Sonbati, M. Abou-Dobara
Summary: In this study, metal polymer complexes of N,N'-1,4-phenylene have been synthesized and characterized using various analytical techniques. The ligand and polymer complex exhibited strong antibacterial activity against Staphylococcus aureus, with molecular docking revealing excellent binding with the receptor of Staphylococcus aureus compared to E. coli.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Physical
A. Z. El-Sonbati, N. F. Omar, M. I. Abou-Dobara, M. A. Diab, M. A. El-Mogazy, Sh. M. Morgan, M. A. Hussien, A. . A. . El-Ghettany
Summary: A novel bis-bidentate azo dye ligand and its metal complexes were synthesized and evaluated for their antibacterial and antifungal activities. The mixed ligand complexes of Cr(III), Mn(II), and UO2(II) showed higher activity compared to the primary ligands.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Polymer Science
Elsayed Elbayoumy, Nasser A. El-Ghamaz, Farid Sh Mohamed, Mostafa A. Diab, Tamaki Nakano
Summary: Semiconductor materials based on metal high crosslinked-vinyl polymer composites were prepared by loading Pd(OAc)(2) on both Poly(ethylene-1,2-diyl dimethacrylate) (poly(EDMA)) and poly(ethylene-1,2-diyl dimethacrylate-co-methyl methacrylate) (Poly(EDMA-co-MMA)). The introduction of Pd(OAc)(2) led to an increase in dielectric permittivity and AC electrical conductivity for the polymers. The materials exhibited semiconductor behavior and the conduction mechanism was proposed to be Quantum Mechanical Tunneling (QMT).
Article
Chemistry, Applied
Adel Z. El-Sonbati, Mostafa A. Diab, Ahmed K. El-Sayed, Mohamed Abou-Dobara, Sameh A. El-Sayad
Summary: Metal complexes of a Schiff base ligand derived from 2,4-dihydroxybenzaldehyde and p-nitroaniline were synthesized and characterized. The complexes showed antibacterial, antifungal, and cytotoxic activities, and the ligand exhibited high binding affinity to various receptors.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Physical
A. Z. El-Sonbati, M. A. El-Mogazy, S. G. Nozha, M. A. Diab, M. I. Abou-Dobara, A. M. Eldesoky, Sh. M. Morgan
Summary: Mixed ligand complexes of five metals were prepared and characterized, with one complex showing higher inhibitory activity against bacteria and fungi than the others.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Applied
Adel Z. El-Sonbati, Mostafa A. Diab, Ahmed K. El-Sayed, Mohamed Abou-Dobara, Aya A. F. Gafer
Summary: Mixed ligand complexes of Cu (II), Ni (II), Co (II), and Mn (II) acetato with a primary ligand L and secondary ligand H2L were isolated and characterized using various analytical techniques, showing promising antibacterial activities against Klebsiella pneumoniae. The study also indicated the efficiency of the ligand in molecular docking experiments and revealed significant DNA cleavage properties for certain complexes.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
A. Z. El-Sonbati, M. A. Diab, Sh M. Morgan, S. Y. Abbas, Gehad G. Mohamed
Summary: A new series of transition metal complexes have been synthesized and characterized. The results show that these metal complexes have higher antibacterial and antifungal activity.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
M. A. Diab, A. Z. El-Sonbati, E. A. Gomaa, M. A. El-Mogazy, Sh M. Morgan, M. Abou-Dobara, N. F. Omar, M. M. El-Zahed, M. A. Osman
Summary: Polymer complexes of 5,5-MODIFIER LETTER PRIME-{(1E, 1E-MODIFIER LETTER PRIME)-1,4-phenylenebis(diazene-2,1-diyl)}bis(quinoline-8-ol) with various metal ions were prepared and characterized. The complexes displayed antibacterial activity, with Mn(II) polymer complex showing higher activation energy and causing cell wall lysis and abnormal cell morphology. Molecular docking predicted efficient binding between 8-hydroxyquinoline and receptors of cancer and bacterial proteins.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2022)
Article
Engineering, Electrical & Electronic
Eman A. Gaml, A. Z. El-Sonabi, M. A. Diab, H. R. Issa
Summary: Complexes of Cu (II) and Co (II) with a specific ligand have been synthesized and characterized. The alternating current conductivity and dielectric properties of these complexes were investigated, revealing their frequency and temperature-dependent behaviors. Different conduction mechanisms were suggested for different complexes.
JOURNAL OF ELECTRONIC MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Smriti Sharma, Sonu Chauhan, Anushree Jatrana, Ravi Kumar, Meena Sindhu
Summary: The Schiff bases ligand, p-chlorobenzylidene-o-aminophenol (CBAP), and its transition metal complexes were synthesized and characterized. The metal complexes exhibited higher antibacterial and antifungal activities compared to the parent ligand.
ANNALS OF PHYTOMEDICINE-AN INTERNATIONAL JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
A. Z. El-Sonbati, M. A. Diab, S. Y. Abbas, Gehad G. Mohamed, Sh M. Morgan
Summary: A novel Schiff base ligand named H2L was prepared and characterized, along with its La(III), Er(III), and Yb(III) complexes. The complexes showed higher antibacterial and antifungal activities compared to the ligand, making them potentially valuable for pharmaceutical research. Additionally, the binding energy values of H2L for colon cancer and lung cancer receptors were discussed.
EGYPTIAN JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
M. A. Diab, Maie ElGammal, M. S. Ibrahim, Ghada A. Mahmoud, S. Sorour, S. Rezoka
EGYPTIAN JOURNAL OF CHEMISTRY
(2019)
Article
Chemistry, Physical
Xinlei Chen, Shiyi Chen, Xuele Lin, Jingxuan Zhou, Xingjun Gao, Yaoqi Zhen, Xiaodan Ma, Shouwen Jin, Linfang Shi, Hui Liu, Daqi Wang
Summary: Nine mixed-ligand Cd2+ complexes with different geometric structures were synthesized and characterized. The complexes exhibit various coordination modes and form both intra- and intermolecular hydrogen bonds.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Rupali Mahajan, Abhishek Sharma, Bhagyashree Patra, Lijo Mani, Parul Grover, Sandeep Kumar, Santosh Kumar Guru, Gananadhamu Samanthula, Amol G. Dikundwar, Amit Asthana
Summary: This research article provides a comprehensive characterization and toxicological assessment of a photoisomeric impurity of the antianemic drug Roxadustat. The impurity has a distinct structure compared to the drug and its formation due to light exposure is a concern. Through various experiments, including single crystal XRD, physicochemical characterization, and in vitro cytotoxicity assays, the researchers confirmed the structure of the impurity, evaluated its conversion with Roxadustat, and assessed its toxicological activity. These findings contribute to the understanding of drug stability, safety, and formulation development.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Laila S. Alqarni, Azzah M. Alghamdi, Nuha Y. Elamin, A. Rajeh
Summary: The solution casting method was used to produce a new type of nanocomposites made of chitosan, gelatin, and co-doped ZnO nanoparticles. The addition of 3.5% co-doped ZnO nanoparticles improved the physicochemical characteristics and antimicrobial effects of the nanocomposites, indicating their significant potential in food packaging and energy storage.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Ruchi Gaur
Summary: The structure and intermolecular interactions of a newly synthesized bis-chalcone THXA were studied using experimental and computational methods. The importance of non-covalent interactions such as pi center dot center dot center dot pi, C-H center dot center dot center dot S, and C-H center dot center dot center dot pi was revealed.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Andrii Bazylevich, Leonid Patsenker, Sarit Aviel-Ronen, Gary Gellerman
Summary: Drug combination therapy is commonly used for treating various skin disorders, but its effectiveness is often limited. In this study, researchers synthesized conjugates of anti-pigmenting drugs and hyaluronic acid (HA) to improve treatment efficacy. These HA-drug conjugates exhibited measurable drug release profiles and demonstrated superior depigmentation effects compared to control groups in a swine model.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Xiaodan Ma, Xinlei Chen, Yaoqi Zhen, Xunjie Zheng, Chengzhe Shi, Shouwen Jin, Bin Liu, Bin Chen, Daqi Wang
Summary: Cocrystallization experiments between minoxidil and aryl acids coformers resulted in the successful formation of multi-component samples. The nature of these samples was determined using various techniques and their structural and supramolecular aspects were investigated. The outcomes revealed the importance of nonbonding contacts and different types of interactions in stabilizing and expanding the crystal structures.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Najla A. Alshaye, Magdy A. Ibrahim, Al-Shimaa Badran
Summary: The chemical behavior of 3-substituted-6,8-dimethylchromones towards phenylhydrazine was examined. Different reaction conditions produced various products, and the molecular geometries and reactivity descriptors of the compounds were also investigated. The results suggest that these compounds are suitable for nonlinear optical applications.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Hayette Alliouche, Houria Bouria, Rafik Bensegueni, Mounia Guergouri, Abdelmalek Bouraiou, Ali Belfaitah
Summary: In this paper, a combined experimental and theoretical study was conducted to synthesize and characterize new 2-quinolone-piperidine and -morpholine hybrids. The results from experiments were validated using computational calculations, and the affinity between these compounds and Acetylcholinesterase/Butyrylcholinesterase was estimated through molecular docking.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Wei-Min Chen, Juan-Juan Shao, Yi Zhang, Zhen-Dong Xue, Peng-Lai Liu, Jian-Ling Ni, Li-Zhuang Chen, Qiang Gao, Fang-Ming Wang
Summary: This study synthesized and characterized a novel Mn-based LMOF, and achieved good results in detecting heavy metal Al3+ in water, showing good stability, high selectivity and sensitivity. This provides new insights into the potential applications of Mn-based MOFs in chemical sensing.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Jun-Xia Li, Yi-Jing Lu, Ke-Ying Quan, Li-Bing Wu, Xun Feng, Wei-Zhou Wang
Summary: This study synthesized two cobalt(II) complexes and analyzed their crystal structures using single-crystal X-ray diffraction. The results showed that the crystal structures of these complexes were different, and they exhibited different crystal packing and magnetic properties.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Yang Li, Yan Zhang, Hong Xu, Min Li, Zhen Li, Zi-yu Song, Ji-shi Chen, Yan-Jun Liu, Yong Sun, Zhao Yang
Summary: This study reports the synthesis and solid-state characterization of a new pharmaceutical cocrystal, PRO-BPE, which can enhance the solubility of the highly water-insoluble prodrug probenecid. The PRO-BPE cocrystals were found to have superior water solubility compared to pure PRO. This research provides valuable insights into improving the solubility of poorly soluble drugs.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Lucas G. B. Felicio, Bianca B. M. Vieira, Ivana S. Lula, Renata Diniz, Frank Alexis, Flavio B. Miguz, Frederico B. De Sousa
Summary: A novel spiropyran derivative was synthesized for heavy metals sensing in water. The results demonstrated that the new derivative can serve as a rapid, sensitive, and simple tool for detecting Hg2+ ions in water with high selectivity.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Junqing Meng, Jie Wang, Lijuan Wang, Chunhui Lyu, Haiyan Chen, Yingpei Lyu, Baisheng Nie
Summary: Material modification with low surface energy can achieve lower surface free energy on micro-and nano-rough structures, which is crucial for developing superhydrophobic surfaces. In this study, attapulgite (APT) was modified with alkylamine, alkylammonium salt, and stearic acid, and the interaction between low surface materials and attapulgite was explained. The results showed that the hydrophobicity of APT was significantly modified by the modifiers, and the surface free energy of the composites first decreased and then increased with increasing molecular number of low surface energy monomers.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Karan Goswami, Dipak Das, Parthasarathi Bera, Sounak Roy, Md. Motin Seikh, Prasanta Kumar Sinha, Arup Gayen
Summary: This work presents the development of a simple and highly active heterogeneous Pd catalyst for Suzuki-Miyaura carbon-carbon cross-coupling reaction. The NiPdFe-1 catalyst shows the best activity and stability among the prepared catalysts. It efficiently promotes the coupling reaction between aryl bromide and phenyl boronic acid under mild reaction conditions with high isolated yields.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Ekta Pardhi, Devendra Singh Tomar, Rahul Khemchandani, Gananadhamu Samanthula, Pankaj Kumar Singh, Neelesh Kumar Mehra
Summary: The main aim of this study was to prepare a drug-drug coamorphous system to improve the physiochemical properties, solubility and stability of Apremilast and Indomethacin. Various solid-state characterization techniques were used to characterize the prepared system. Molecular level interactions were studied using molecular modeling and ATR-FTIR and 1H NMR. Solubility and dissolution studies showed the benefits of the coamorphous system. The system was found to be stable for a period of five months. Permeation study also demonstrated improved flux for both drugs compared to their crystalline forms. The coamorphous system showed anti-psoriatic and anti-melanogenic activity based on molecular docking results. Overall, the developed CAM-based supersaturated system exhibited improved physicochemical properties and physical stability.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
