Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 997, Issue 1-3, Pages 78-86Publisher
ELSEVIER
DOI: 10.1016/j.molstruc.2011.05.001
Keywords
Chitosan; Microspheres; Anti-inflammatory drugs; Molecular spectroscopy
Categories
Funding
- Romanian Research and Education Ministry [PN-09-44 02 01/2009, PN-09-44 02 05/2009, PN II 72-190/2008]
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The use of chitosan as an excipient in oral formulations, as a drug delivery vehicle for ulcerogenic anti-inflammatory drugs and as base in polyelectrolyte complex systems, to prepare solid release systems as sponges was investigated. The preparation by double emulsification of chitosan hydrogels carrying diclofenac, acetyl-salycilic acid and hydrocortisone acetate as anti-inflammatory drugs is reported. The concentration of anti-inflammatory drug in the chitosan hydrogel generating the sponges was 0.08 mmol. Chitosan-drug loaded sponges with anti-inflammatory drugs were prepared by freeze-drying at -60 degrees C and 0.009 atm. Structural investigations of the solid formulations were done by Fourier-transformed infrared and ultraviolet-visible spectroscopy, spectrofluorimetry, differential scanning calorimetry and X-ray diffractometry. The results indicated that the drug molecules are forming temporary chelates in chitosan hydrogels and sponges. Electron paramagnetic resonance demonstrates the presence of free radicals in a wide range and the antioxidant activity for chitosan-drug supramolecular crosslinked assemblies. (C) 2011 Elsevier B.V. All rights reserved.
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