Journal
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
Volume 21, Issue 7, Pages 787-793Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10837450.2015.1055766
Keywords
Dissolving microneedle; sinomenine hydrochloride; transdermal drug delivery
Categories
Funding
- National Natural Science Foundation of China [81274099]
- Natural Science Foundation of Anhui Province [11040606M219]
- Natural Science Foundation of the Anhui Higher Education Institutions of China [KJ2012A184]
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Sinomenine hydrochloride-loaded dissolving microneedles (SH-DM) were fabricated by maltose and poly-lactic-co-glycolic acid using a casting method. The mechanical strength of SH-DM was investigated by an insertion test. In vivo transdermal absorption experiment was performed to evaluate the percutaneous absorption of SH-DM, sinomenine hydrochloride gel (SH-G) was used as a control. The results demonstrated that prepared SH-DM was morphologically intact with sufficient mechanical strength after inserting into aluminum foil and rat skin. The value of area under curve obtained after administration of SH-DM through transdermal in rabbits showed a significantly rise and was 1.99 times higher than that of SH-G, and the relative bioavailability value was 199.21%. These results showed that SH-DM enhanced bioavailability and permeability of SH.
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