Article
Chemistry, Inorganic & Nuclear
Giriraj Kalaiarasi, Pathinathan Senthilrajkapoor, Ramasamy Indumathy
Summary: Four new bivalent ruthenium(II) organometallic complexes were synthesized and characterized. The complexes showed significant antimicrobial activity and anticancer potential, exceeding that of their parent ligands and the standard drug cisplatin.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Electrochemistry
Amani S. Alturiqi, Eida S. Al-Farraj, Murefah M. Anazy, Reda A. Ammar
Summary: Formation equilibria of Zn(II) with tryptophan as a representative example of amino acids in presence of certain NSAIDS such as aspirin, ibuprofen and naproxen were studied using pH-metric titrations. The study determined the protonation constants and stability constants of the ligands in EtOH-H2O solutions. The formation of complexes in different pH regions was established, and the relative stabilities of the ternary complexes were compared with those of the corresponding binary complexes.
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
(2022)
Review
Polymer Science
Agnieszka Folentarska, Jakub Lagiewka, Magdalena Krystyjan, Wojciech Ciesielski
Summary: This paper investigates the interactions between polysaccharides with different electrical charges (anionic and neutral starches) and proteins and fats in food ingredients, aiming to understand the mechanisms and interdependence between their properties and intermolecular interactions. It fills the gap in research on ternary blends of natural food polymers and presents the application of natural biopolymers in the food and non-food industries.
Article
Chemistry, Applied
Kalaiarasi Giriraj, Mohamed Subarkhan Mohamed Kasim, Keerthana Balasubramaniam, Sathiya Kamatchi Thangavel, Janani Venkatesan, Sharmila Suresh, Pritha Shanmugam, Chiranjeevi Karri
Summary: Four Co (III) complexes containing substituted acetyl coumarin Schiff bases were synthesized and structurally characterized, showing two of the complexes with similar coordination behavior and the other two with different coordination modes. These complexes demonstrated higher anticancer activity than the standard drug and ligands, specifically targeting cancer cells and inducing cell death through apoptosis.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Review
Chemistry, Inorganic & Nuclear
Maryam Bashir, Maryam Saifullah, Mubeshar Riaz, Muhammad Arshad, Ahmad Irfan, Sadia Iqbal, Zahoor H. Farooqi, Robina Begum
Summary: This mini review summarizes the potential applications of phloroglucinol derivatives in various fields. Different groups of scientists have explored various derivatives of phloroglucinol for a wide range of applications. The review focuses on the synthesis, structural, medicinal, catalytic, and enzyme inhibitory importance of phloroglucinol Schiff bases and their metal complexes.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Daphne S. Cukierman, Nikolett Bodnar, Renata Diniz, Lajos Nagy, Csilla Kallay, Nicolas A. Rey
Summary: In this study, two novel 1-methylimidazole N-acylhydyrazonic ligands and their interaction with copper(II) were described. The affinities of these ligands for zinc(II) were determined for comparison. The stability of ternary complexes involving a hydrazonic metal-protein interaction modulator, copper, and a peptide was investigated, showing promise for potential therapeutic approaches in neurodegenerative diseases.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Youjun Zhou, Qing Wang, Longtao Ma, Jingwen Fan, Ying Han, Chaoguo Yan
Summary: Cocktail therapy is a leading approach for treating complex diseases. In this study, a pH-triggered supramolecular cocktail drug delivery system was developed, which efficiently encapsulated doxorubicin to enhance its anti-cancer efficiency while maintaining live-cell imaging property.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Marek Pajak, Magdalena Wozniczka, Marta E. Lichawska, Bartlomiej Czerwinski, Jakub Wlodarczyk, Jakub Fichna
Summary: This study investigates the complexation properties of oxime-containing Schiff bases with Co(II) ions and their potential application as synthetic oxygen transporters. The obtained data can contribute to the development of oxygen bioinorganic complexes and catalytic activity research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Antonio Gigliuto, Rosalia Maria Cigala, Anna Irto, Maria Rosa Felice, Alberto Pettignano, Concetta De Stefano, Francesco Crea
Summary: The interactions of dopamine with cadmium, copper, and uranyl were studied at different ionic strengths and temperatures, resulting in different speciation models. The studies showed that dopamine has different sequestering abilities towards cadmium, copper, and uranyl ions, with uranyl having the highest sequestering ability followed by copper and then cadmium.
Review
Food Science & Technology
Tiffany Amat, Ali Assifaoui, Christophe Schmitt, Remi Saurel
Summary: Legumes are a good source of plant-based proteins, but their high phytic acid content may impair their nutritional value. This review examines the mechanisms and factors influencing the formation of protein/phytic acid/calcium complexes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Chemistry, Multidisciplinary
Mohammad Nasir Uddin, Sajeda Begum, Jebunnisa Akter, Sayeda Samina Ahmed, Md Saifur Rahman, Wahhida Shumi
Summary: Ternary complexes of vanadium(IV) and titanium(IV) containing macrocyclic chelate ring were synthesized and their stable formation and optimized structure were confirmed. Some of the complexes exhibited good antioxidant properties and inhibition capacity against pathogenic microorganisms. Molecular docking analysis showed one ligand had comparable binding affinity to SARS-CoV-2 main protease, indicating its potential as a candidate against SARS-CoV-2 infection. ADMET analysis suggested it was noncarcinogenic and less toxic.
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2022)
Review
Engineering, Environmental
Sikandar Khan, Xiaojing Chen, Albandary Almahri, Esam S. Allehyani, Fahad A. Alhumaydhi, Munjed M. Ibrahim, Shujat Ali
Summary: Schiff bases are compounds synthesized through the condensation reaction of primary amines with carbonyl compounds, showing potential applications in medicine and chemical sensing. They coordinate with various metal ions to form stable complexes and are utilized as chemical sensors for detecting different metal ions.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Review
Chemistry, Inorganic & Nuclear
Muhammad Pervaiz, Anfal Munir, Aqsa Riaz, Zohaib Saeed, Umer Younas, Muhammad Imran, Sami Ullah, Rashida Bashir, Ayoub Rashid, Ahmad Adnan
Summary: Schiff base ligands and their metal complexes have gained significant attention due to their wide range of applications and unique structural features. They have been extensively used in various fields, including material science and biology, because of their broad-spectrum biological activities.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Review
Engineering, Electrical & Electronic
Sneha Kagatikar, Dhanya Sunil
Summary: Optoelectronics is a field of active research focusing on developing semiconducting materials with a wide emission window for energy conservation and improved device lifetime. Efficient material design for OLEDs has been a key area of research, along with the exploration of metal-organic compounds for OLED applications.
JOURNAL OF ELECTRONIC MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Hanan B. Howsaui, Amal S. Basaleh, Magda H. Abdellattif, Walid M. Hassan, Mostafa A. Hussien
Summary: Three novel 2-aminopyrazine Schiff bases and their uranyl complexes were synthesized and characterized, with studies on DNA binding and anticancer activities showing promising results. Molecular docking analysis provided insights into interactions with cancer proteins.
Article
Chemistry, Organic
Hamdy S. El-Sheshtawy, Awatef S. Assran, Ahmed M. AbouBaker
POLYCYCLIC AROMATIC COMPOUNDS
(2019)
Article
Chemistry, Multidisciplinary
Awatef S. Assran, Natalya V. Izarova, Ulrich Kortz
Article
Chemistry, Inorganic & Nuclear
Awatef S. Assran, Sib Sankar Mal, Natalya V. Izarova, Abhishek Banerjee, Andreas Suchopar, Masahiro Sadakane, Ulrich Kortz
DALTON TRANSACTIONS
(2011)
Article
Chemistry, Inorganic & Nuclear
Awatef S. Assran, Natalya V. Izarova, Abhishek Banerjee, Usama M. Rabie, Moustafa H. M. Abou-El-Wafa, Ulrich Kortz
DALTON TRANSACTIONS
(2012)
Article
Chemistry, Physical
Hemat M. Dardeer, Awatef S. Assran, Sami A. Al-Hussain, Arafat Toghan
Summary: This study synthesized a series of promising new derivatives, screened for their antimicrobial activities, characterized through spectroscopy, and studied for their solvatochromic behavior. The compounds showed good antibacterial activity, with compound I being the most active, along with exhibiting solvatochromism. Molecular docking studies indicated that these compounds could potentially impact the Rab20 site in human pancreatic tumors.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Physical
Xinlei Chen, Shiyi Chen, Xuele Lin, Jingxuan Zhou, Xingjun Gao, Yaoqi Zhen, Xiaodan Ma, Shouwen Jin, Linfang Shi, Hui Liu, Daqi Wang
Summary: Nine mixed-ligand Cd2+ complexes with different geometric structures were synthesized and characterized. The complexes exhibit various coordination modes and form both intra- and intermolecular hydrogen bonds.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Rupali Mahajan, Abhishek Sharma, Bhagyashree Patra, Lijo Mani, Parul Grover, Sandeep Kumar, Santosh Kumar Guru, Gananadhamu Samanthula, Amol G. Dikundwar, Amit Asthana
Summary: This research article provides a comprehensive characterization and toxicological assessment of a photoisomeric impurity of the antianemic drug Roxadustat. The impurity has a distinct structure compared to the drug and its formation due to light exposure is a concern. Through various experiments, including single crystal XRD, physicochemical characterization, and in vitro cytotoxicity assays, the researchers confirmed the structure of the impurity, evaluated its conversion with Roxadustat, and assessed its toxicological activity. These findings contribute to the understanding of drug stability, safety, and formulation development.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Laila S. Alqarni, Azzah M. Alghamdi, Nuha Y. Elamin, A. Rajeh
Summary: The solution casting method was used to produce a new type of nanocomposites made of chitosan, gelatin, and co-doped ZnO nanoparticles. The addition of 3.5% co-doped ZnO nanoparticles improved the physicochemical characteristics and antimicrobial effects of the nanocomposites, indicating their significant potential in food packaging and energy storage.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Ruchi Gaur
Summary: The structure and intermolecular interactions of a newly synthesized bis-chalcone THXA were studied using experimental and computational methods. The importance of non-covalent interactions such as pi center dot center dot center dot pi, C-H center dot center dot center dot S, and C-H center dot center dot center dot pi was revealed.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Andrii Bazylevich, Leonid Patsenker, Sarit Aviel-Ronen, Gary Gellerman
Summary: Drug combination therapy is commonly used for treating various skin disorders, but its effectiveness is often limited. In this study, researchers synthesized conjugates of anti-pigmenting drugs and hyaluronic acid (HA) to improve treatment efficacy. These HA-drug conjugates exhibited measurable drug release profiles and demonstrated superior depigmentation effects compared to control groups in a swine model.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Xiaodan Ma, Xinlei Chen, Yaoqi Zhen, Xunjie Zheng, Chengzhe Shi, Shouwen Jin, Bin Liu, Bin Chen, Daqi Wang
Summary: Cocrystallization experiments between minoxidil and aryl acids coformers resulted in the successful formation of multi-component samples. The nature of these samples was determined using various techniques and their structural and supramolecular aspects were investigated. The outcomes revealed the importance of nonbonding contacts and different types of interactions in stabilizing and expanding the crystal structures.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Najla A. Alshaye, Magdy A. Ibrahim, Al-Shimaa Badran
Summary: The chemical behavior of 3-substituted-6,8-dimethylchromones towards phenylhydrazine was examined. Different reaction conditions produced various products, and the molecular geometries and reactivity descriptors of the compounds were also investigated. The results suggest that these compounds are suitable for nonlinear optical applications.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Hayette Alliouche, Houria Bouria, Rafik Bensegueni, Mounia Guergouri, Abdelmalek Bouraiou, Ali Belfaitah
Summary: In this paper, a combined experimental and theoretical study was conducted to synthesize and characterize new 2-quinolone-piperidine and -morpholine hybrids. The results from experiments were validated using computational calculations, and the affinity between these compounds and Acetylcholinesterase/Butyrylcholinesterase was estimated through molecular docking.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Wei-Min Chen, Juan-Juan Shao, Yi Zhang, Zhen-Dong Xue, Peng-Lai Liu, Jian-Ling Ni, Li-Zhuang Chen, Qiang Gao, Fang-Ming Wang
Summary: This study synthesized and characterized a novel Mn-based LMOF, and achieved good results in detecting heavy metal Al3+ in water, showing good stability, high selectivity and sensitivity. This provides new insights into the potential applications of Mn-based MOFs in chemical sensing.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Jun-Xia Li, Yi-Jing Lu, Ke-Ying Quan, Li-Bing Wu, Xun Feng, Wei-Zhou Wang
Summary: This study synthesized two cobalt(II) complexes and analyzed their crystal structures using single-crystal X-ray diffraction. The results showed that the crystal structures of these complexes were different, and they exhibited different crystal packing and magnetic properties.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Yang Li, Yan Zhang, Hong Xu, Min Li, Zhen Li, Zi-yu Song, Ji-shi Chen, Yan-Jun Liu, Yong Sun, Zhao Yang
Summary: This study reports the synthesis and solid-state characterization of a new pharmaceutical cocrystal, PRO-BPE, which can enhance the solubility of the highly water-insoluble prodrug probenecid. The PRO-BPE cocrystals were found to have superior water solubility compared to pure PRO. This research provides valuable insights into improving the solubility of poorly soluble drugs.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Lucas G. B. Felicio, Bianca B. M. Vieira, Ivana S. Lula, Renata Diniz, Frank Alexis, Flavio B. Miguz, Frederico B. De Sousa
Summary: A novel spiropyran derivative was synthesized for heavy metals sensing in water. The results demonstrated that the new derivative can serve as a rapid, sensitive, and simple tool for detecting Hg2+ ions in water with high selectivity.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Junqing Meng, Jie Wang, Lijuan Wang, Chunhui Lyu, Haiyan Chen, Yingpei Lyu, Baisheng Nie
Summary: Material modification with low surface energy can achieve lower surface free energy on micro-and nano-rough structures, which is crucial for developing superhydrophobic surfaces. In this study, attapulgite (APT) was modified with alkylamine, alkylammonium salt, and stearic acid, and the interaction between low surface materials and attapulgite was explained. The results showed that the hydrophobicity of APT was significantly modified by the modifiers, and the surface free energy of the composites first decreased and then increased with increasing molecular number of low surface energy monomers.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Karan Goswami, Dipak Das, Parthasarathi Bera, Sounak Roy, Md. Motin Seikh, Prasanta Kumar Sinha, Arup Gayen
Summary: This work presents the development of a simple and highly active heterogeneous Pd catalyst for Suzuki-Miyaura carbon-carbon cross-coupling reaction. The NiPdFe-1 catalyst shows the best activity and stability among the prepared catalysts. It efficiently promotes the coupling reaction between aryl bromide and phenyl boronic acid under mild reaction conditions with high isolated yields.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Ekta Pardhi, Devendra Singh Tomar, Rahul Khemchandani, Gananadhamu Samanthula, Pankaj Kumar Singh, Neelesh Kumar Mehra
Summary: The main aim of this study was to prepare a drug-drug coamorphous system to improve the physiochemical properties, solubility and stability of Apremilast and Indomethacin. Various solid-state characterization techniques were used to characterize the prepared system. Molecular level interactions were studied using molecular modeling and ATR-FTIR and 1H NMR. Solubility and dissolution studies showed the benefits of the coamorphous system. The system was found to be stable for a period of five months. Permeation study also demonstrated improved flux for both drugs compared to their crystalline forms. The coamorphous system showed anti-psoriatic and anti-melanogenic activity based on molecular docking results. Overall, the developed CAM-based supersaturated system exhibited improved physicochemical properties and physical stability.
JOURNAL OF MOLECULAR STRUCTURE
(2024)