Review
Biochemistry & Molecular Biology
Jun Watanabe, Kazuhiko Kotani, Alejandro Gugliucci
Summary: Overall, patients with COPD had lower PON1 activity, indicating impaired PON1-related antioxidant defense in COPD. Further studies are needed.
Article
Biochemistry & Molecular Biology
Guangbi Li, Dandan Huang, Ningjun Li, Joseph K. Ritter, Pin-Lan Li
Summary: The study found that ROS levels increased in podocytes after Hcy stimulation, leading to activation of NLRP3 inflammasomes and the presence of inflammatory cytokines in MVBs. Inhibiting NADPH oxidase and using ROS scavengers prevented these effects.
Article
Medicine, General & Internal
Jun Watanabe, Kazuhiko Kotani, Alejandro Gugliucci
Summary: This study conducted a meta-analysis on the relationship between oxidative stress and paraoxonase 1 (PON1) in chronic kidney disease (CKD). The results showed that CKD patients had lower PON1 activity compared to healthy controls. Further studies are needed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Cristina Antinozzi, Paolo Sgro, Francesco Marampon, Daniela Caporossi, Francesco Del Galdo, Ivan Dimauro, Luigi Di Luigi
Summary: Oxidative stress is crucial in the pathogenesis of systemic sclerosis (SSc), affecting the inflammatory state, fibrosis, and tissue damage. Studies show that the phosphodiesterase type 5 inhibitor sildenafil can reduce the expression and secretion of pro-inflammatory chemokines in dermal fibroblasts of SSc patients.
Article
Biochemistry & Molecular Biology
Kenneth R. Olson, Kasey J. Clear, Paul J. Derry, Yan Gao, Zhilin Ma, Gang Wu, Thomas A. Kent, Karl D. Straub
Summary: In the canonical pathway for mitochondrial H2S oxidation, CoQ(10) and its truncated forms CoQ(1) and CoQ(0) can catalyze the oxidation of H2S to polysulfides and thiosulfate. Among them, CoQ(0) exhibits the highest potency in oxidizing H2S to per-polysulfides. These reactions consume oxygen and the oxidation of H2S is attributed to the quinones rather than superoxide. Similar reactions are observed for related quinones such as MitoQ, menadione, and idebenone.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Kenneth R. Olson, Kasey J. Clear, Paul J. Derry, Yan Gao, Zhilin Ma, Nathaniel M. Cieplik, Alyssa Fiume, Dominic J. Gaziano, Stephen M. Kasko, Kathleen Narloch, Cecilia L. Velander, Ifeyinwa Nwebube, Collin J. Pallissery, Ella Pfaff, Brian P. Villa, Thomas A. Kent, Gang Wu, Karl D. Straub
Summary: This study investigates the reaction mechanism of NQ oxidation of H2S to produce RSS using various experimental methods. The results show that NQ can oxidize H2S to per- and polysulfides, consuming oxygen and being accelerated by SOD while inhibited by catalase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Ji-Hye Lee, Hiroshi Uyama, Oh-Kyoung Kwon, Young-Jin Kim
Summary: The study explores the integration of multi-modal therapies using a PLIN monolith to enhance PTT efficacy in treating osteosarcomas and regenerating bone defects. The PLIN monolith exhibits enhanced photothermal activity on osteosarcomas without causing phototoxicity in normal osteoblasts, and induces significant apoptotic cell death in cancer cells.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Hieronim Jakubowski
Summary: High-density lipoprotein (HDL) has cardio- and neuro-protective properties, which are mediated by paraoxonase 1 (PON1), an enzyme associated with a specific HDL subfraction. Reduced levels of PON1 activity, characterized by elevated levels of specific metabolites, are associated with cardiovascular and neurological abnormalities. Recent studies have highlighted the role of dysregulated proteostasis in the disease phenotypes associated with low PON1 activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Cellas A. Hayes, Brandon G. Ashmore, Akshaya Vijayasankar, Jessica P. Marshall, Nicole M. Ashpole
Summary: The reduction of IGF-1 in aging is associated with increased risk of stroke and neurodegenerative diseases. IGF-1 promotes neuronal survival by acting directly on neurons and indirectly on astrocytes, indicating the importance of maintaining IGF-1 levels for the health of the entire neuro-glio-vascular unit.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Oncology
Kyungho Kim, Eun-Young Choi, Hye-Mi Ahn, Dong-Gun Kim, Youn-Jae Kim
Summary: This study investigates the role of HBQ1 in lung adenocarcinoma and finds that elevated expression of HBQ1 in adenocarcinoma tissues is associated with poor survival. HBQ1 acts as an oncogene, promoting cell proliferation, and also has antioxidant properties. The findings suggest that HBQ1 plays a crucial role in lung adenocarcinoma progression and may serve as a diagnostic marker and therapeutic target.
Article
Chemistry, Multidisciplinary
Mei Wen, Nuo Yu, Zhigao Yi, Pu Qiu, Cheng Tao, Daniel K. Macharia, Meifang Zhu, Zhigang Chen, Xiaogang Liu
Summary: Conventional photo/sonosensitizers lack selectivity and cause severe skin and retina phototoxicity. The use of a copper-hematoporphyrin monomethyl ether nanoframework (CuHF) can suppress fluorescence on healthy tissues and prevent phototoxicity to the skin and eyes. In addition, this nanoframework can react with endogenous hydrogen sulfide in colon cancer cells, enabling simultaneous photothermal and sonodynamic therapies.
Article
Environmental Sciences
Wan-He Li, Zheng-Ting-Yan Xiang, An-Xin Lu, Su-Su Wang, Chong-Huai Yan
Summary: Manganese (Mn) is an essential trace element that maintains normal physiological functions, but overexposure to Mn can lead to multi-system disorders, especially neurotoxicity. This study investigated the modulation of the ROS-activated JNK/FOXO3a signaling pathway in Mn-induced apoptosis using a rat brain astrocyte cell line (CTX cells). The results showed that Mn decreased cell viability of CTX cells in a dose-dependent manner and induced apoptosis by altering the expression of apoptosis-related proteins. Treatment with Mn also resulted in elevated ROS levels and increased phosphorylation levels of JNK, while phosphorylation of FOXO3a was decreased. Depletion of ROS and inhibition of the JNK pathway prevented Mn-induced apoptosis. These findings provide insights into the neurotoxic mechanisms of Mn and potential therapeutic targets.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Nanoscience & Nanotechnology
Swathi Balaji, Walker D. Short, Benjamin W. Padon, Jorge A. Belgodere, Sarah E. Jimenez, Naresh T. Deoli, Anna C. Guidry, Justin C. Green, Tanuj J. Prajapati, Fayiz Farouk, Aditya Kaul, Dongwan Son, Olivia S. Jung, Carlos E. Astete, Myungwoong Kim, Jangwook P. Jung
Summary: In this study, functionalized lignin was used to provide antioxidation to the extracellular microenvironments of wounds and deliver oxygen for enhanced vascularization and healing. Lignin composites with oxygen-generating nanoparticles were found to release a significant amount of oxygen per day for at least 7 days. The in situ formation of these composites enhanced tissue granulation, blood vessel formation, and fibroblast infiltration, and remodeled collagen architecture after 28 days.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Weirun Li, Peier Chen, Yuxuan Pan, Ling Lu, Xiaodong Ning, Jiamin Liu, Jintao Wei, Minsheng Chen, Peng Zhao, Caiwen Ou
Summary: By using a complex scaffold and nanocomposite scaffold, a band-aid like patch can slowly release H2S and attach to the myocardium, relieving inflammation and promoting angiogenesis after myocardial infarction and recovering heart function.
Article
Chemistry, Physical
Guangshan Xie, Lin Zhu, Yanhao Zhang, Yuanyuan Song, Hongna Zhang, Zhu Yang, Zongwei Cai
Summary: 1-Nitropyrene (1-NP) is a potential carcinogen found in diesel exhaust-derived fine particulate matter (PM2.5) with higher cytotoxicity compared to its analogs. In human lung epithelial cell lines, 1-NP induces acute reactive oxygen species (ROS) generation and cell death. Through redox proteomics analysis, it was discovered that 1-NP remodels the redox proteome and targets the ROS reduction pathway, specifically inhibiting SOD1 activity by acting on Cys111 residue. The position of nitroxide determines the direct target of 1-NP, proposing a novel mechanism for its cytotoxicity and ROS induction.
Article
Biochemistry & Molecular Biology
Daniela Giustarini, Valerio Tazzari, Ivan Bassanini, Ranieri Rossi, Anna Sparatore
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Medicinal
Ivan Bassanini, Silvia Parapini, Nicoletta Basilico, Anna Sparatore
Article
Oncology
Ryan T. Bishop, Silvia Marino, Giovana Carrasco, Boya Li, Richard J. Allen, Anna Sparatore, Penelope D. Ottewell, Patrick Mollat, Andrew H. Sims, Mattia Capulli, Ning Wang, Aymen I. Idris
Article
Biochemistry & Molecular Biology
Lissette Carolina Sanchez-Aranguren, Homira Rezai, Shakil Ahmad, Faisal A. Alzahrani, Anna Sparatore, Keqing Wang, Asif Ahmed
Article
Biochemistry & Molecular Biology
Homira Rezai, Shakil Ahmad, Faisal A. Alzahrani, Lissette Sanchez-Aranguren, Irundika H. K. Dias, Swati Agrawal, Anna Sparatore, Keqing Wang, Asif Ahmed
Summary: Preeclampsia is a common and serious complication affecting millions of pregnant women worldwide. This study found that a novel H2S-releasing aspirin can ameliorate preeclampsia by reducing hypertension and renal damage through possibly stimulating antioxidant genes, improving fetal outcomes compared to aspirin alone.
Article
Chemistry, Medicinal
Michele Tonelli, Anna Sparatore, Nicoletta Basilico, Loredana Cavicchini, Silvia Parapini, Bruno Tasso, Erik Laurini, Sabrina Pricl, Vito Boido, Fabio Sparatore
Article
Biochemistry & Molecular Biology
Gian Marco Tosi, Daniela Giustarini, Lorenzo Franci, Alberto Minetti, Francesco Imperatore, Elena Caldi, Paolo Fiorenzani, Anna Maria Aloisi, Anna Sparatore, Ranieri Rossi, Mario Chiariello, Maurizio Orlandini, Federico Galvagni
Summary: Oxidative stress is crucial in the pathophysiology of retinal diseases, with NACET showing potential as a more efficient alternative to NAC in preventing and treating AMD, by increasing intracellular GSH levels and enhancing oxidative stress resistance in RPE cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jaimy Saif, Shakil Ahmad, Homira Rezai, Karina Litvinova, Anna Sparatore, Faisal A. Alzahrani, Keqing Wang, Asif Ahmed
Summary: An imbalanced angiogenic growth factors and poor utero-placental perfusion are strongly correlated with preeclampsia. A refined RUPP model in C57B1/6 J mice was developed to test the efficacy of MZe786 as a potential inhibitor of soluble Flt-1 for preeclampsia therapy. The study demonstrated that MZe786 treatment successfully prevented the development of preeclampsia by reducing maternal MAP and kidney nitrotyrosine staining, and improving fetal outcomes.
Article
Biochemistry & Molecular Biology
Ivan Bassanini, Silvia Parapini, Erica E. Ferrandi, Elena Gabriele, Nicoletta Basilico, Donatella Taramelli, Anna Sparatore
Summary: The study utilized the natural triterpene celastrol as a lead compound for designing and synthesizing a panel of eleven CE carboxamides, which were tested in vitro for their growth inhibitory activity against Leishmania parasites. Four of these compounds showed nanomolar leishmanicidal activity and low toxicity towards human and murine cell lines. The most selective CE analogue also inhibited the ATPase activity of Leishmania protein chaperone Hsp90, suggesting potential for future biochemical investigations.
Article
Pharmacology & Pharmacy
Silvia Marino, Nicole Hannemann, Ryan T. Bishop, Feier Zeng, Giovana Carrasco, Sandrine Meurisse, Boya Li, Antonia Sophocleous, Anna Sparatore, Tobias Baeuerle, Slobodan Vukicevic, Marielle Auberval, Patrick Mollat, Aline Bozec, Aymen I. Idris
Summary: TRAF6 inhibitors may be beneficial in managing the inflammatory component of bone disorders, but they may not provide protection against local or systemic bone loss unless combined with anti-resorptive therapy.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Alexey Koval, Ivan Bassanini, Jiabin Xu, Michele Tonelli, Vito Boido, Fabio Sparatore, Frederic Amant, Daniela Annibali, Eleonora Leucci, Anna Sparatore, Vladimir L. Katanaev
Summary: Clofazimine has been optimized to enhance its potency as a Wnt inhibitor, with MU17 identified as a more potent lead compound for targeted therapy against TNBC and Wnt-dependent cancers. MU17 displayed a 7-fold improved potency against Wnt signaling in TNBC cells and showed no adverse effects, particularly no clofazimine-related skin coloration.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Neurosciences
Kun-Li Yang, Wen-Hong Li, Ya-Jie Liu, Ying-Juan Wei, Yan-Kai Ren, Chen-Di Mai, Si-Yu Zhang, Yue Zuo, Zhen-Zhou Sun, Dong-Liang Li, Chih-Huang Yang
Summary: This study found that hydrogen sulfide can protect the central nervous system, alleviate neuroinflammation caused by stroke, and improve brain and retinal injuries by blocking the NLRP3 inflammasome pathway. The findings suggest that hydrogen sulfide compounds could be a potential therapeutic strategy for ischemic stroke.
Article
Biochemistry & Molecular Biology
Nicoletta Basilico, Silvia Parapini, Sarah D'Alessandro, Paola Misiano, Sergio Romeo, Giulio Dondio, Vanessa Yardley, Livia Vivas, Shereen Nasser, Laurent Renia, Bruce M. Russell, Rossarin Suwanarusk, Francois Nosten, Anna Sparatore, Donatella Taramelli
Summary: The novel pyrrolizidinylmethyl derivative MG3 showed excellent antimalarial activity against drug-resistant parasites, both in vitro and in vivo. The compound exhibited comparable or better efficacy than chloroquine and other quinolines in rodent models of malaria, and its pharmacological profile met the requirements for further development.
Article
Clinical Neurology
Manli Li, Xiaoli Ma, Chendi Mai, Zhiru Fan, Yangyang Wang, Yankai Ren
Summary: This study used VOSviewer and CiteSpace to assess the current state of insular epilepsy research and determine research hotspots and prospective directions. The findings identified surgical treatment, functional network connectivity, and the application of neuroimaging methods as hot topics and research frontiers in the field of insular epilepsy.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Pharmacology & Pharmacy
Kunli Yang, Hu Luo, Yajie Liu, Yankai Ren, Meixia Guo, Bin Wang, Chih-huang Yang, Dongliang Li
Summary: This study found that hydrogen sulfide (H2S) can protect neural cells from damage induced by high concentrations of ATP. ATP induces cytotoxicity in PC12 cells through the endogenous H2S/CBS system, and supplementation with exogenous H2S can mitigate this damage.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
