Cellular Effects of Progranulin in Health and Disease

GEP, a Local Growth Factor, is Critical for Odontogenesis and Amelogenesis

(2012) Zhengguo Cao et al.   International Journal of Biological Sciences

Progranulin Is a Chemoattractant for Microglia and Stimulates Their Endocytic Activity

(2011) Fiona Pickford et al.   AMERICAN JOURNAL OF PATHOLOGY

HDL/Apolipoprotein A-I Binds to Macrophage-Derived Progranulin and Suppresses its Conversion into Proinflammatory Granulins

(2011) Hanayuki Okura et al.   Journal of Atherosclerosis and Thrombosis

Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice

(2011) Moshe Elkabets et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

(2011) Thomas Philips et al.   LANCET NEUROLOGY

A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells

(2011) A. W. Kao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

Genome-wide Screen Identifies rs646776 near Sortilin as a Regulator of Progranulin Levels in Human Plasma

(2010) Minerva M. Carrasquillo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging

(2010) Zeshan Ahmed et al.   AMERICAN JOURNAL OF PATHOLOGY

Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis

(2010) Jian Q. Feng et al.   FASEB JOURNAL

Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia

(2010) Fangfang Yin et al.   FASEB JOURNAL

Granulin-Epithelin Precursor and ATP-Dependent Binding Cassette (ABC)B5 Regulate Liver Cancer Cell Chemoresistance

(2010) Siu Tim Cheung et al.   GASTROENTEROLOGY

Progranulin is a potential prognostic biomarker in advanced epithelial ovarian cancers

(2010) Jasmine J. Han et al.   GYNECOLOGIC ONCOLOGY

Progranulin A-mediated MET Signaling Is Essential for Liver Morphogenesis in Zebrafish

(2010) Yen-Hsing Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Progranulin expression in the developing and adult murine brain

(2010) Terri L. Petkau et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Microglial Upregulation of Progranulin as a Marker of Motor Neuron Degeneration

(2010) Thomas Philips et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Progranulin modulates zebrafish motoneuron development in vivo and rescues truncation defects associated with knockdown of Survival motor neuron 1

(2010) Babykumari P Chitramuthu et al.   Molecular Neurodegeneration

TAR DNA-binding protein 43 in neurodegenerative disease

(2010) Alice S. Chen-Plotkin et al.   Nature Reviews Neurology

Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin

(2010) Fenghua Hu et al.   NEURON

Progranulin is Neurotrophic In Vivo and Protects against a Mutant TDP-43 Induced Axonopathy

(2010) Angela S. Laird et al.   PLoS One

Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β

(2010) Xue Gao et al.   Protein & Cell

Progranulin expression is upregulated after spinal contusion in mice

(2009) Swati B. Naphade et al.   ACTA NEUROPATHOLOGICA

Proepithelin Regulates Prostate Cancer Cell Biology by Promoting Cell Growth, Migration, and Anchorage-Independent Growth

(2009) Giada Monami et al.   AMERICAN JOURNAL OF PATHOLOGY

Serum biomarker for progranulin-associated frontotemporal lobar degeneration

(2009) Kristel Sleegers et al.   ANNALS OF NEUROLOGY

Progranulin expression in advanced human atherosclerotic plaque

(2009) Yoji Kojima et al.   ATHEROSCLEROSIS

Progranulin is expressed within motor neurons and promotes neuronal cell survival

(2009) Cara L Ryan et al.   BMC NEUROSCIENCE

Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members

(2009) N. Finch et al.   BRAIN

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

(2009) Fangfang Yin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin

(2009) Dorothee Dormann et al.   JOURNAL OF NEUROCHEMISTRY

Pathogenic cysteine mutations affect progranulin function and production of mature granulins

(2009) Jun Wang et al.   JOURNAL OF NEUROCHEMISTRY

ADAMTS-7, a Direct Target of PTHrP, Adversely Regulates Endochondral Bone Growth by Associating with and Inactivating GEP Growth Factor

(2009) X.-H. Bai et al.   MOLECULAR AND CELLULAR BIOLOGY

Gene expression study on peripheral blood identifies progranulin mutations

(2008) Giovanni Coppola et al.   ANNALS OF NEUROLOGY

Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: Implications for TDP-43 in the physiological response to neuronal injury

(2008) Katie Moisse et al.   BRAIN RESEARCH

Cortical Atrophy and Language Network Reorganization Associated with a Novel Progranulin Mutation

(2008) Carlos Cruchaga et al.   CEREBRAL CORTEX

Serum Progranulin Concentrations May Be Associated With Macrophage Infiltration Into Omental Adipose Tissue

(2008) B.-S. Youn et al.   DIABETES

Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma

(2008) Jenny C. Ho et al.   HEPATOLOGY

Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia

(2008) Odity Mukherjee et al.   HUMAN MUTATION

Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

(2008) Philip Van Damme et al.   JOURNAL OF CELL BIOLOGY

Progranulin, a secreted tumorigenesis and dementia-related factor, regulates mouse hair growth

(2008) Maki Kato et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Novel MMP-9 Substrates in Cancer Cells Revealed by a Label-free Quantitative Proteomics Approach

(2008) Danmei Xu et al.   MOLECULAR & CELLULAR PROTEOMICS

Pharmacoproteomics of a Metalloproteinase Hydroxamate Inhibitor in Breast Cancer Cells: Dynamics of Membrane Type 1 Matrix Metalloproteinase-Mediated Membrane Protein Shedding

(2008) G. S. Butler et al.   MOLECULAR AND CELLULAR BIOLOGY

Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration

(2008) R. Ghidoni et al.   NEUROLOGY