Article
Biochemistry & Molecular Biology
Chuan-Ching Lai, Rathinasamy Baskaran, Chih-Yu Tsao, Li-Heng Tuan, Pei-Fen Siow, Mahalakshmi Palani, Lukas Jyuhn-Hsiarn Lee, Chih-Min Liu, Hai-Gwo Hwu, Li-Jen Lee
Summary: Schizophrenia usually manifests during adolescence to young adulthood, providing an opportunity for early intervention. This study investigated the preventive effect of chronic N-acetylcysteine (NAC) treatment on the outbreak of psychosis in Disc1 Het mice and found that NAC can normalize biochemical and morphological features in the striatum. The findings not only support the use of NAC as a dietary supplement for schizophrenia prodromes, but also contribute to our understanding of potential therapeutic targets for treating mental disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Fillipe Mendes De Araujo, Annyta Fernandes Frota, Livia Bacelar de Jesus, Ticiane Caribe Macedo, Lorena Cuenca-Bermejo, Consuelo Sanchez-Rodrigo, Kariny Maria Silva Ferreira, Juciele Valeria Ribeiro de Oliveira, Maria de Fatima Dias Costa, Juan Segura-Aguilar, Silvia Lima Costa, Maria Trinidad Herrero, Victor Diogenes Amaral Silva
Summary: This study observed that aminochrome induced neuroinflammation, including microgliosis, astrogliosis, and dopaminergic neuronal loss, in an in vivo model. The findings reinforce the potential of aminochrome as a useful preclinical model for finding anti-inflammatory and neuroprotective drugs for Parkinson's disease.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Clinical Neurology
Berangere Detraux, Antonietta Vilella, Aurelie De Groote, Serge N. Schiffmann, Michele Zoli, Alban de Kerchove d'Exaerde
Summary: The study investigates the specific role of different neuronal subpopulations in the striatum, especially dMSNs, in male copulatory behavior. Results show a complex and cell-specific contribution to copulatory behavior, with dMSNs playing a prominent role in both dorsal and ventral striatal regions.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Wouter van Elzelingen, Jessica Goedhoop, Pascal Warnaar, Damiaan Denys, Tara Arbab, Ingo Willuhn
Summary: Dopamine signals in the striatum play a critical role in motivated behavior. The release and modulation of dopamine in different regions of the striatum vary, while prediction-error signals are limited to specific regions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Monica Pardo, Sara Gregorio, Enrica Montalban, Lluis Pujadas, Alba Elias-Tersa, Nuria Masachs, Alba Vilchez-Acosta, Annabelle Parent, Carme Auladell, Jean-Antoine Girault, Miquel Vila, Angus C. C. Nairn, Yasmina Manso, Eduardo Soriano
Summary: Reelin protein is implicated in psychiatric disorders, but its effects on the structure and neuronal composition of the striatum are not well understood. This study found that overexpression of Reelin protein increases the numbers of striatal interneurons and cholinergic neurons, and slightly increases the tyrosine hydroxylase-positive projections from the substantia nigra to the striatum. These findings suggest that increased levels of Reelin may protect against neuropsychiatric disorders by modifying these structures and neuronal numbers.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Henrik Tonner, Selina Hunn, Nadine Auler, Carsten Schmelter, Vanessa M. Beutgen, Harald D. von Pein, Norbert Pfeiffer, Franz H. Grus
Summary: In this study, intravitreal injection of anti-HMGB1 Ab was found to reduce HMGB1-dependent inflammatory signaling and improve RGC neuronal survival in an experimental animal model of glaucoma. Mass spectrometric analysis demonstrated increased abundance of RNA metabolism-associated hnRNPs in animals injected with the antibody, while microarray analysis showed a decreased expression of inflammatory mediators in the HMGB1 group. These findings suggest that anti-HMGB1 Ab may play a neuroprotective role in glaucoma by modulating inflammatory processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Sanjeev K. Bhardwaj, Qiming Cui, Luc Moquin, Alain Gratton, Bruno Giros, Lalit K. Srivastava
Summary: Reduced expression of schizophrenia-associated gene DTNBP1 and its protein product dysbindin-1 in the brains of schizophrenia patients has been reported. Mouse models with DTNBP1 knockout show altered dopaminergic, glutamatergic, and GABAergic neurotransmission in cortico-limbic regions. Dysbindin-1 deficiency in dopamine neurons leads to impaired mesolimbic dopamine transmission, affecting locomotor behavior and prepulse inhibition.
Article
Behavioral Sciences
Molly Brady, Anna Beltramini, Gavin Vaughan, Allison R. Bechard
Summary: This study found that the ketogenic diet can reduce abnormal repetitive circling behavior in a rodent model, and this effect may be related to the striatum.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Review
Health Care Sciences & Services
Daniela Senior, Rania Ahmed, Eliz Arnavut, Alexandra Carvalho, Wen Xuan Lee, Kenneth Blum, David E. Komatsu, Michael Hadjiargyrou, Rajendra D. Badgaiyan, Panayotis K. Thanos
Summary: The majority of animal studies on methylphenidate (MP) use methods such as intraperitoneal injections, subcutaneous injections, or the oral gavage route. However, the most clinically relevant route is oral administration. Intraperitoneal injections provide an immediate and maximum dose, but only represent a limited window of the drug's effects. Subcutaneous injections do not accurately reflect oral exposure, and the oral-gavage method has adverse effects and may be stressful for animals. The use of a two-bottle drinking method allows for free consumption of MP and more accurately mirrors human treatment, enabling the study of MP's effects on development, behavior, neurochemistry, and brain function.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Neurosciences
Jack F. Webster, Sanne Beerens, Christian Wozny
Summary: Early life stress can lead to depression in humans and depressive-like behavior in rodents. The lateral habenula (LHb) has been found to become hyperactive after early life stress in various animal models of depression. However, whether these pathological changes persist into adulthood is not well understood. A study using the maternal separation (MS) model of depression in mice found that a weak depressive phenotype persists into adulthood, which is surprisingly associated with LHb hypoactivity. The LHb neurons are in a sensitized state, making them more responsive to re-exposure to stress and leading to LHb hyperactivity. This study provides insights into the mechanisms underlying depression relapse.
NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Cindy Bandala, Noemi Cardenas-Rodriguez, Julieta Griselda Mendoza-Torreblanca, Itzel Jatziri Contreras-Garcia, Valentin Martinez-Lopez, Teresita Rocio Cruz-Hernandez, Jazmin Carro-Rodriguez, Marco Antonio Vargas-Hernandez, Ivan Ignacio-Mejia, Alfonso Alfaro-Rodriguez, Eleazar Lara-Padilla
Summary: Dopamine (DA), its derivatives, and dopaminergic drugs are widely used in the management of neurological and non-neurological diseases due to their therapeutic potential as anti-inflammatories and antioxidants. This review article compiled the mechanism of action of DA and the main dopaminergic drugs, highlighting their use in various pathologies and their emerging role in repositioning for other disorders.
Article
Immunology
Shan Qiao, Shan-Chao Zhang, Zhi-Hao Wang, Lei Wang, Ran-Ran Zhang, Hai-Yun Li, Yang Jin, Ling-Ling Liu, Mei-Ling Wang, Ai-Hua Wang, Xue-Wu Liu
Summary: This study investigated the clinical characteristics and significance of overlapping multiple anti-neuronal antibodies in patients with autoimmune encephalitis (AE). Among the 276 AE antibody-positive patients, 7.97% had two or more antibodies. The main symptoms of patients with coexisting antibodies included fever, seizures, memory impairment, cognitive decline, and sleep disorders. The study also found that the presence of multiple antibodies may indicate an underlying malignancy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ornela Kljakic, Helena Janickova, Miguel Skirzewski, Amy Reichelt, Sara Memar, Salah El Mestikawy, Yulong Li, Lisa M. Saksida, Timothy J. Bussey, Vania F. Prado, Marco A. M. Prado
Summary: In the striatum, cholinergic interneurons can release both acetylcholine and glutamate, and their individual and combined contributions to behavior regulation were assessed in mice using reward-based touchscreen tests. Changes in VAChT and VGLUT3 levels have different effects on reward responses, and the simultaneous loss of both vesicular transporters affects dopamine signaling and behavior in a more severe way than the loss of VAChT alone. This shows that the ability of CINs to secrete two different neurotransmitters allows for complex modulation of various behaviors.
Review
Neurosciences
Carli L. Poisson, Liv Engel, Benjamin T. Saunders
Summary: Addiction is a complex disease characterized by substance use disorder (SUD), with primary symptoms including exaggerated substance use, social impairment, and risky behavior. Research on rodent models suggests that the striatal dopamine system plays a crucial role in both positive symptoms like increased intake and craving, and impairments in decision making, reduced sociality, and risk taking associated with SUDs. Understanding the heterogeneity of the dopamine system and related networks may lead to more targeted treatments for addiction.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Neurosciences
Jessica Goedhoop, Tara Arbab, Ingo Willuhn
Summary: By comparing two different experimental paradigms, this study reveals that dopamine signals contain both reward-related and action-related information. The action component of dopamine release is characterized by sustained signals, which reflect the motivation for appetitive action.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Owen B. Samuels, Ofer Sadan, Chen Feng, Kathleen Martin, Khalid Medani, Yajun Mei, Daniel L. Barrow
Summary: The study observed an increase in patient acuity and complications over time in aSAH cases. The prevalence of endovascular therapies was correlated with better outcomes. While functional outcomes improved, systemic complications remained a significant risk factor for poor prognosis.
Article
Critical Care Medicine
Feras Akbik, Cederic Pimentel-Farias, Di'Jonai A. Press, Niara E. Foster, Kevin Luu, Merin G. Williams, Sena G. Andea, Regina K. Kyei, Grace M. Wetsel, Jonathan A. Grossberg, Brian M. Howard, Frank Tong, C. Michael Cawley, Owen B. Samuels, Ofer Sadan
Summary: The study compared the clinical course and functional outcomes of patients with perimesencephalic SAH, diffuse SAH, and aneurysmal SAH, revealing that aneurysmal SAH is associated with more complications and longer hospital stays, while perimesencephalic SAH has a more favorable prognosis.
NEUROCRITICAL CARE
(2022)
Meeting Abstract
Clinical Neurology
Jackson A. Narrett, Ethan D. Assefa, Arti Patel, Indika Mallawaarachchi, Johanna J. Loomba, Sarah Ratcliffe, Ofer Sadan, Teshamae Monteith, Bradford B. Worrall, Donald E. Brown, Karen C. Johnston, Andrew M. Southerland
Editorial Material
Clinical Neurology
Feras Akbik, Ofer Sadan
Article
Ethics
Nyiramugisha K. Niyibizi, Candace D. Speight, Gabriel Najarro, Andrea R. Mitchell, Ofer Sadan, Yi-An Ko, Neal W. Dickert
Summary: This study aimed to evaluate the impact of improvements to informed consent forms on the likelihood of enrollment and understanding. The results suggest that tailored language and modified key information can improve understanding of the study, but have little effect on enrollment likelihood.
BMC MEDICAL ETHICS
(2022)
Article
Critical Care Medicine
Steven Philips, Yuyang Shi, Craig M. Coopersmith, Owen B. Samuels, Cederic Pimentel-Farias, Yajun Mei, Ofer Sadan, Feras Akbik
Summary: Neurointensivists trained in neurology provided comparable critical care outcomes to general intensivists during the surges of COVID-19, supporting the role of neurocritical care in meeting the general critical care needs of neurocritically ill patients and as a viable surge resource.
NEUROCRITICAL CARE
(2023)
Editorial Material
Clinical Neurology
Ofer Sadan, Feras Akbik
Letter
Clinical Neurology
Feras Akbik, Heather-Destiny Konan, Kayla P. Williams, Leelt M. Ermias, Yuyang Shi, Obai Takieddin, Jonathan A. Grossberg, Brian M. Howard, Frank Tong, C. Michael Cawley, Yajun Mei, Owen B. Samuels, Ofer Sadan
Article
Neurosciences
Jackson A. Narrett, Indika Mallawaarachchi, Chad M. Aldridge, Ethan Assefa, Arti Patel, Johanna J. Loomba, Sarah Ratcliffe, Ofer Sadan, Teshamae Monteith, Bradford B. Worrall, Donald E. Brown, Karen C. Johnston, Andrew M. Southerland
Summary: This study conducted a retrospective observational analysis using the N3C database to examine the association between concurrent SARS-CoV-2 infection and stroke severity. The findings revealed that patients with concurrent SARS-CoV-2 infection had increased stroke severity, longer hospital stays, and higher odds of death compared to those without infection.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Clinical Neurology
Eashani Sathialingam, Kyle R. Cowdrick, Amanda Y. Liew, Zhou Fang, Seung Yup Lee, Courtney E. McCracken, Feras Akbik, Owen B. Samuels, Prem Kandiah, Ofer Sadan, Erin M. Buckley
Summary: One common complication of non-traumatic subarachnoid hemorrhage (SAH) is delayed cerebral ischemia (DCI). In this observational study, the researchers used diffuse correlation spectroscopy (DCS) to measure the acute microvascular cerebral blood flow response to intrathecal nicardipine in 20 patients with SAH. They found that the response varied among patients, with some showing no significant change in blood flow and others showing a pronounced increase. The incidence of DCI was significantly higher in the group without significant blood flow change.
FRONTIERS IN NEUROLOGY
(2023)
Meeting Abstract
Critical Care Medicine
Feras Akbik, Yuyang Shi, Di'Jonai Press, Niara Foster, Merin Williams, Sena Andea, Regina Kyei, Grace Wetsel, Steven Phillips, Cederic Pimentel, Owen Samuels, Yajun Mei, Ofer Sadan
CRITICAL CARE MEDICINE
(2023)
Meeting Abstract
Critical Care Medicine
Ofer Sadan, Shany Cohen-Sadan, Eashani Sathialingam, Erin Buckley, William Asbury, Owen Samuels
CRITICAL CARE MEDICINE
(2023)
Meeting Abstract
Critical Care Medicine
Eashani Sathialingam, Kyle Cowdrick, Tara Urner, Amanda Liew, Feras Akbik, Owen Samuels, Prem Kandiah, Erin Buckley, Ofer Sadan
CRITICAL CARE MEDICINE
(2023)
Meeting Abstract
Critical Care Medicine
Randi Connor-Schuler, Steven Phillips, Emory Ren Kuo, Prem Kandiah, Ofer Sadan
CRITICAL CARE MEDICINE
(2022)
Article
Clinical Neurology
Ofer Sadan, Hannah Waddel, Renee Moore, Chen Feng, Yajun Mei, David Pearce, Jacqueline Kraft, Cederic Pimentel, Subin Mathew, Feras Akbik, Pouya Ameli, Alexis Taylor, Lisa Danyluk, Kathleen S. Martin, Krista Garner, Jennifer Kolenda, Amit Pujari, William Asbury, Blessing N. R. Jaja, R. Loch Macdonald, C. Michael Cawley, Daniel L. Barrow, Owen Samuels
Summary: This study describes the experience of using intrathecal nicardipine in patients with subarachnoid hemorrhage. Compared to untreated patients, the treated group had a lower rate of delayed cerebral ischemia, improved functional outcome, but higher rates of ventriculoperitoneal shunting.
JOURNAL OF NEUROSURGERY
(2022)
