Article
Biotechnology & Applied Microbiology
Mustafa Ozkan, Nurullah Gunay, Elif Funda Sener, Ozgur Karcioglu, Reyhan Tahtasakal, Fatma Dal, Nahide Ekici Gunay, Abdullah Tuncay Demiryurek
Summary: The study revealed significant associations between TNF gene (-308G/A, rs1800629) and NOS3 gene -786T/C (rs2070744) polymorphisms with susceptibility to sepsis in the Turkish population. No significant associations were found with other polymorphisms studied in this research.
JOURNAL OF GENE MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jennifer C. Hill, Marie Billaud, Tara D. Richards, Mary P. Kotlarczyk, Sruti Shiva, Julie A. Phillippi, Thomas G. Gleason
Summary: This study found differential expression of Nos3 related to valve morphology and aneurysm, providing new insights into the pathophysiology of aneurysms and supporting the idea that mechanisms of ascending aortopathy in BAV and TAV patients are distinct.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Multidisciplinary Sciences
Ruichao Li, Ansu Zhao, Xiaoyan Diao, Juhui Song, Chanjuan Wang, Yanhong Li, Xiaolan Qi, Zhizhong Guan, Ting Zhang, Yan He
Summary: This study found that the single nucleotide polymorphisms rs1808593 and rs7830 of the NOS3 gene are associated with essential hypertension in the Han, Miao, and Buyi populations in Guizhou, China.
Article
Pharmacology & Pharmacy
Jiaojiao Wang, Zhiping Liu, Jing Lu, Jiami Zou, Weile Ye, Hong Li, Si Gao, Peiqing Liu
Summary: This study found that SIRT6 regulates endothelial function by modulating the activity of NOS3. SIRT6 activates NOS3 through deacetylation and facilitates its interaction with calmodulin, leading to increased nitric oxide generation.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Cell Biology
Serena Dato, Francesco De Rango, Paolina Crocco, Stefano Pallotti, Michael E. Belloy, Yann Le Guen, Michael D. Greicius, Giuseppe Passarino, Giuseppina Rose, Valerio Napolioni
Summary: Advanced age is the biggest risk factor for late-onset Alzheimer's disease (LOAD), and it shares genetic signatures with longevity. The study found evidence that pathways leading to longevity also contribute to LOAD, and identified interacting genes that are associated with survival to old age. The findings suggest that interactions of risk factors may drive different trajectories of cognitive aging.
Article
Biochemistry & Molecular Biology
Karolina A. P. Wijnands, Dennis M. Meesters, Benjamin Vandendriessche, Jacob J. Briede, Hans M. H. van Eijk, Peter Brouckaert, Anje Cauwels, Wouter H. Lamers, Martijn Poeze
Summary: Competition between NOS3 and NOS2 for arginine during endotoxemia appears crucial in the derangement of microcirculatory flow. This study found that L-citrulline supplementation enhances de novo arginine synthesis and NO production in mice during endotoxemia, especially in mice with functional NOS3-enzyme.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Serena Dato, Francesco De Rango, Paolina Crocco, Stefano Pallotti, Michael E. Belloy, Yann Le Guen, Michael D. Greicius, Giuseppe Passarino, Giuseppina Rose, Valerio Napolioni
Summary: Advanced age is the biggest risk factor for late-onset Alzheimer's disease (LOAD), with shared genetic signatures between LOAD and longevity. Gene-gene interactions in pathways related to insulin/IGF1 signaling, DNA repair, and oxidative stress were found to affect LOAD. These findings suggest that risk factor interactions may drive different trajectories of cognitive aging.
Article
Medicine, Research & Experimental
Shupeng Hu, Qiangzhong Pi, Xiudan Xu, Jianghong Yan, Yongzheng Guo, Wanying Tan, An He, Zhe Cheng, Suxin Luo, Yong Xia
Summary: This study investigates the role of eNOS in vascular dysfunction induced by sepsis. Increased phosphorylation of eNOS in early sepsis leads to decreased vasodilation, while decreased levels of eNOS in late sepsis result in diminished nitric oxide-dependent relaxation responses.
Article
Pharmacology & Pharmacy
Qing-Fan Lin, Jing-Hong Rao, Shi-Mu Luo, Qing-Mu Wang, Li-Feng Deng, Xuan Chen, Chang-Di Chen, You-Fang Chen
Summary: This study found that gene polymorphisms of eNOS were associated with the development of PAH in newborns with CHD in South Fujian. Specifically, the GT/TT genotype of eNOS rs1799983 was associated with a higher risk of PAH, and this may be due to decreased nitric oxide production.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Clinical Neurology
Valeria Isella, Daniele Licciardo, Giulia Nastasi, Valentina Impagnatiello, Francesca Ferri, Cristina Mapelli, Cinzia Crivellaro, Monica Musarra, Sabrina Morzenti, Ildebrando Appollonio, Carlo Ferrarese
Summary: Late-onset and early-onset dementia exhibit neurobiological and clinical differences. This study compared the clinical and FDG-PET features of posterior cortical atrophy (PCA), the visual variant of Alzheimer's disease, between late-onset and early-onset cases. The results showed that the main difference between the two groups was a higher prevalence of Balint-Holmes symptoms in the early-onset cases, which was associated with severe bilateral occipito-temporo-parietal hypometabolism. In the late-onset cases, there was a reduction of FDG uptake mainly in the right posterior regions. Age was found to be correlated with metabolism in different brain regions.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Angelina J. J. Polsinelli, Kathleen A. A. Lane, Mohit K. K. Manchella, Paige E. E. Logan, Sujuan Gao, Liana G. G. Apostolova
Summary: The study investigated the impact of APOE epsilon 4 status and sex on age of symptom onset in both early-onset and late-onset Alzheimer's disease. Results showed that APOE epsilon 4 carriers had earlier symptom onset in late-onset AD and later symptom onset in early-onset AD. Female carriers of APOE epsilon 4 in early-onset AD had later symptom onset, while both male and female carriers in late-onset AD had earlier symptom onset. This suggests the presence of additional AD risk variants in non-carriers of APOE epsilon 4, particularly in females.
ALZHEIMERS & DEMENTIA
(2023)
Article
Cell Biology
Zhi-Ren Tsai, Han-Wei Zhang, Chun-Hung Tseng, Hsiao-Ching Peng, Victor C. Kok, Gao Ping Li, Chao A. Hsiung, Chun-Yi Hsu
Summary: A retrospective cohort study conducted in Taiwan showed that individuals with epilepsy are at a significantly increased risk of developing dementia, especially those aged 50 years and above.
Article
Medicine, Research & Experimental
Jun -Ha Hwang, Woong Heo, Jung Il Park, Kyung Min Kim, Ho Taek Oh, Gi Don Yoo, Jeekeon Park, Somin Shin, Youjin Do, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Summary: Endothelial TAZ is involved in the production of nitric oxide (NO) and inhibits damage-induced liver fibrosis. It regulates NO production by transcriptional regulation of Nos3. Loss of TAZ leads to capillarization of liver sinusoidal endothelial cells and a decrease in NO concentration, accelerating liver fibrosis.
Article
Clinical Neurology
Alexander M. Kulminski, Ian Philipp, Yury Loika, Liang He, Irina Culminskaya
Summary: The protective role of the apolipoprotein E (APOE) epsilon 2 allele in Alzheimer's disease (AD) may be influenced by different immunomodulation functions of TOMM40 and APOE variants in a sex-specific manner, defining a more homogeneous AD-protective epsilon 2/epsilon 3-bearing profile in men.
ALZHEIMERS & DEMENTIA
(2021)
Article
Neurosciences
Alexa Ruel, Florian Bolenz, Shu-Chen Li, Adrian Fischer, Ben Eppinger
Summary: Under high cognitive demands, older adults tend to rely on simpler and habitual decision strategies due to impairments in the representation of cognitive maps or state spaces. The neural mechanisms underlying this shift in decision behavior are still unclear.
Article
Psychology, Biological
Yi Kuang, Yuan-Na Huang, Shu Li
Summary: Different representations of spatial choice problems can lead to changes in individuals' preference orders. In this study, we found a time-space framing effect, where people's preferences for spatial choice problems were significantly altered by different descriptions. Additionally, we determined that the attribute-comparison model better accounted for this effect.
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY
(2023)
Article
Environmental Sciences
Yingsen Wang, Richeng Liu, Haoqi Ji, Shuchen Li, Liyuan Yu, Xianda Feng
Summary: With the rapid increase in world energy consumption and exhaustion of conventional energy reserves, shale gas has attracted worldwide attention. This study focuses on the mechanical properties and fracture behavior of shale, using fractal dimensions to analyze the distribution of fragmentations and crack patterns. Through uniaxial compression tests and micro-CT scanning, the relationship between mechanical properties and fractal dimensions is explored. The results show that fractal dimensions can help predict the peak strength and elastic modulus, providing new insights for the study of shale's mechanical properties and failure characteristics.
ENVIRONMENTAL EARTH SCIENCES
(2023)
Article
Psychology, Multidisciplinary
Shen Si-Chu, Khishignyam Bazarvaani, Ding Yang, Ma Jia-Tao, Yang Shu-Wen, Kuang Yi, Xu Ming-Xing, John E. Taplin, Li Shu
Summary: Humans are currently facing an unprecedented historical crisis and challenge. To cope with this crisis, we should investigate two strategies: slow strategy and fast strategy. Through studying people's choices at different time points, we find that the slow strategy is more beneficial for survival in environmental crises.
ACTA PSYCHOLOGICA SINICA
(2023)
Article
Neurosciences
Shu-Chen Li, Frank H. P. Fitzek
Summary: The mechanisms underlying perceptual processing and inference change significantly across the lifespan. The emerging Tactile Internet (TI) aims to enable humans to interact with remote and virtual environments through digitalized multimodal sensory signals, including the haptic sense. These technologies provide opportunities for researching digitally embodied perception and cognition, as well as the differences across age groups. However, there are challenges in integrating empirical findings and theories into engineering research and technological development, such as signal transmission noise and the decline of neurotransmitters during aging. Neuronal gain control of perceptual processing and inference presents potential interfaces for developing age-adjusted technologies for digital embodiment in perceptual and cognitive interactions.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Neurosciences
Christian Baeuchl, Franka Gloeckner, Christoph Koch, Johannes Petzold, Nicolas W. Schuck, Michael N. Smolka, Shu-Chen Li
Summary: The aging process leads to changes in spatial navigation behavior, with older adults relying more on proximal location cues instead of environmental boundaries. Deficient dopaminergic modulation may contribute to errors during spatial navigation in older adults. Administering levodopa in young and older adults affected brain responses and memory retrieval differently, with older adults showing upregulation in the medial temporal lobe and brainstem. While L-DOPA had no effect on older adults' overall memory performance, it improved spatial memory and increased boundary processing in some individuals.
Article
Engineering, Geological
Liyuan Yu, Dongyang Wu, Haijian Su, Shuchen Li, Richeng Liu, Shentao Geng
Summary: The roughness and stress state of a rock-concrete interface have significant effects on its tensile behavior and failure mechanisms. Natural rough surfaces were obtained using splitting tests, and the fractal dimension of the rough surface was calculated. Rock-concrete specimens with different rough interfaces were prepared using a 3D engraving technique and subjected to Brazilian splitting tests at different loading angles. The results showed that the loading angle had a greater influence on the mechanical properties than the interfacial roughness, and a rough interface could inhibit crack propagation and improve the tensile strength of the sample.
ROCK MECHANICS AND ROCK ENGINEERING
(2023)
Article
Multidisciplinary Sciences
Johannes Steffen, Dimitrije Markovic, Franka Gloeckner, Philipp T. Neukam, Stefan J. Kiebel, Shu-Chen Li, Michael N. Smolka
Summary: Forward planning is crucial in complex sequential decision-making, and this study found that age is a factor that affects forward planning. Older adults showed shorter planning depths and used more simplified strategies. These findings are important for understanding changes in decision-making behavior in older adults.
SCIENTIFIC REPORTS
(2023)
Article
Metallurgy & Metallurgical Engineering
Shang Liu, Shu-chen Li, Ri-cheng Liu, Li-yuan Yu, Ying-sen Wang
Summary: This study experimentally investigated the evolutions of normal stiffness of fractured granites after different temperature treatments. The influences of normal displacement (delta(n)), initial aperture (b), temperature (T), and saturated condition on the closing behavior of specimens with different openings under normal stress are systematically investigated. The results show that the changing rate of normal stiffness increases gradually with the increment of normal displacement following a quadratic function. When the normal displacement is the same, the stiffness of the specimen with a larger initial opening is relatively smaller. For specimens with various initial openings, the stiffness of saturated specimens decreases with the increasing T (from 25 degrees C to 600 degrees C) by 48.18 % when the rotation angle (alpha) is 20 degrees and delta(n)= 1 mm. When T=25 degrees C and alpha=20 degrees, the stiffnesses of dry and saturated specimens are 27.31 GPa/m and 19.32 GPa/m, respectively. Finally, two empirical models are proposed to evaluate the variations in stiffness of specimens which are correlated to the parameters such as T, b, and normal strain, and the predicted results are in good agreement with the experimental results.
JOURNAL OF CENTRAL SOUTH UNIVERSITY
(2023)
Article
Green & Sustainable Science & Technology
Ming-Xing Xu, Shu Li, Li-Lin Rao, Lei Zheng
Summary: Previous research has neglected the influence of proximity to the epicenter on perception and response to supply chain risk. This study aims to fill this gap by investigating the impact of distance on supply chain disruption risk perception and response. An online survey was conducted with 1055 managers in the supply chain of ZTE, revealing the psychological typhoon eye effect, where those closer to the epicenter perceive lower risk and are less likely to take management action. Risk information quality mediates this relationship, while job position level moderates the relationship between risk information quality and disruption risk perception. To mitigate this effect, high-quality information synchronization is needed beyond individual company initiatives.
Article
Psychology, Multidisciplinary
Huang Yuanna, Jiang Chengming, Liu Hongzhi, Li Shu
Summary: The fundamental issue about the difference between humans and animals has puzzled researchers across various academic fields. The ability to trade is seen as an important distinction between humans and animals, and this study focuses on the choice processes involved in trading activities. The findings show that decision makers tend to use a dimension-based strategy in making choices, and the evaluations of intangible elements against tangible ones are supported.
ACTA PSYCHOLOGICA SINICA
(2023)
Article
Engineering, Multidisciplinary
Zhenguo Liu, Shuchen Li, Richeng Liu, Changzhou Zheng
Summary: The nonlinear flow properties of Newtonian fluids through crossed fractures were studied by considering the effects of fracture length, aperture, and roughness. Computational runs were conducted for 36 domains, solving the Navier-Stokes equations. The results showed a nonlinear relationship between flow rate and hydraulic gradient, with streamlines becoming distorted at high gradients. The critical hydraulic gradient decreased with increasing mechanical aperture, while the joint roughness coefficient had minimal impact.
CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES
(2023)
