Article
Nutrition & Dietetics
Mayuko Kazama, Masakazu Terauchi, Tamami Odai, Kiyoko Kato, Naoyuki Miyasaka
Summary: This study investigated the relationship between dietary consumption of various nutrients and headaches in middle-aged women. It found that higher intake of isoflavones was associated with a lower frequency of headaches in peri- and post-menopausal women, suggesting that a diet rich in isoflavones may help improve headaches in middle-aged women.
Article
Nutrition & Dietetics
Sebastian T. Soukup, Ann Katrin Engelbert, Bernhard Watzl, Achim Bub, Sabine E. Kulling
Summary: This study investigated the microbial metabolite profile of soy isoflavones and classified the population into 5 isoflavone metabotypes based on their metabolite profiles. These metabotypes differed significantly in their metabolite composition and estrogenic potency.
Review
Nutrition & Dietetics
Hans van der Eecken, Steven Joniau, Charlien Berghen, Kato Rans, Gert De Meerleer
Summary: The link between diet and cancer is being explored, with a focus on phytochemicals. Soy isoflavones, especially genistein, daidzein and the derivative equol, have been studied for their potential roles in reducing the risk of prostate cancer. Various mechanisms of action at the cellular level have been identified, spanning hormone-mediated pathways, cell cycle regulation, apoptosis, angiogenesis, metastasis, as well as antioxidant and anti-inflammatory effects. This review provides a comprehensive comparison of these mechanisms among the different soy isoflavones.
Article
Biochemistry & Molecular Biology
Aya Kitagawa, Mana Yamaguchi, Aki Fujiwara, Muneshige Shimizu, Azusa Takahashi, Hideyuki Sone, Shin Kamiyama
Summary: The study found that genistein and daidzein inhibit chondrogenesis in ATDC5 cells and have an impact on genes related to chondrocyte differentiation. Genistein decreased calcium deposition during chondrogenic differentiation, but increased calcification under non-chondrogenic mineralizing conditions.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Food Science & Technology
Souad Bensaada, Francois Chabrier, Pascal Ginisty, Carine Ferrand, Gabriele Peruzzi, Marc Valat, Catherine Bennetau-Pelissero
Summary: Soy is a popular source of protein, but the presence of isoflavones raises concerns due to their estrogenic activities. This study aims to develop a pilot-scale process for extracting isoflavones from soybeans while maintaining nutritional quality. The process involves optimizing key factors, scaling up the process, and adapting to technical constraints. The results show that the pilot treatment successfully reduces isoflavone levels while preserving nutritional characteristics, and techniques are used to recover isoflavones from process waters.
Article
Agronomy
Ji-Seok Lee, Hong-Sig Kim, Tae-Young Hwang
Summary: This study investigated the protein and isoflavone contents of 300 soybean germplasms from different countries, with findings showing variations both in terms of country of origin and size/color. Protein content was highest in soybeans from Korea, while total isoflavone content was highest in soybeans from Japan. Positive correlation was found among daidzein, glycitein, and genistein isoflavone contents, with a low negative correlation between total isoflavone and protein content.
Article
Plant Sciences
Dounya Knizia, Jiazheng Yuan, Nacer Bellaloui, Tri Vuong, Mariola Usovsky, Qijian Song, Frances Betts, Teresa Register, Earl Williams, Naoufal Lakhssassi, Hamid Mazouz, Henry T. Nguyen, Khalid Meksem, Alemu Mengistu, My Abdelmajid Kassem
Summary: This study constructed a genetic linkage map using SNP markers and identified 27 QTL controlling seed isoflavone traits, along with 130 candidate genes involved in isoflavone biosynthetic pathways. The identified QTL and candidate genes are valuable for breeding soybean cultivars with high beneficial isoflavone contents.
Article
Plant Sciences
Matheus Luis Oliveira Cunha, Lara Caroline Alves de Oliveira, Vinicius Martins Silva, Gabriel Sgarbiero Montanha, Andre Rodrigues dos Reis
Summary: This study investigated the effects of selenium application on various aspects of peanut plants, including photosynthetic pigments, oxidant metabolism, flavonoids biosynthesis, nodulation, and agronomic traits. The results showed that selenium fertilization increased the concentration of photosynthetic pigments, activity of antioxidant enzymes, as well as growth and yield of peanut plants. It also improved nitrogen assimilation efficiency and promoted the synthesis of certain compounds in the roots, leading to increased nodulation and transportation of nutrients to the leaves.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Allergy
Takahito Chiba, Takuya Nagai, Futoshi Kohda, Takeshi Nakahara, Michihiro Kono
Summary: The study found that urinary equol levels were significantly lower in atopic dermatitis patients compared to healthy controls, particularly noticeable in young people. No correlations were found between urinary equol levels and the severity of clinical symptoms and laboratory data in atopic dermatitis patients.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Article
Plant Sciences
Yimin Chang, Luning Zhou, Xuewen Hou, Tianjiao Zhu, Blaine A. Pfeifer, Dehai Li, Xiaoxi He, Guojian Zhang, Qian Che
Summary: Sixteen new biisoflavones were discovered from the culture of Streptomyces sp. HDN154127, derived from the Takla Makan desert. The structures of the compounds were determined using NMR, MS, and ECD analyses, and they exhibited significant antibacterial activity.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Ming-Sin Ng, Yee-Shan Ku, Wai-Shing Yung, Sau-Shan Cheng, Chun-Kuen Man, Liu Yang, Shikui Song, Gyuhwa Chung, Hon-Ming Lam
Summary: Soybeans are nutritionally important for humans and animals, rich in proteins, oils, and health-beneficial isoflavones. Research shows that GmMATE1 and GmMATE2 play a role in promoting the accumulation of isoflavones in soybean cells, mainly located in the vacuolar membrane.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Kyung-Chul Shin, Su-Hwan Kang, Deok-Kun Oh, Dae Wook Kim, Sae Hyun Kim, Chae Sun Na, Yeong-Su Kim
Summary: The study reveals that wild soybeans have a higher level of isoflavone content, which can be converted into isoflavone aglycones through a thermostable beta-galactosidase. This enzyme efficiently hydrolyzes isoflavone glycosides in wild soybeans, contributing to the industrial production of isoflavone aglycone.
APPLIED SCIENCES-BASEL
(2022)
Article
Pharmacology & Pharmacy
Katerina Spanou, Ana Isabel Barbosa, Anastasia Detsi, Sofia A. Costa Lima, Salette Reis
Summary: Lipid-based nanoplatforms, especially gel-like matrices, have shown promising potential for skin delivery of drugs. In this study, a gel-like matrix based on freeze-dried nanostructured lipid carriers was developed to deliver genistein to the skin. The genistein-loaded nanoparticles exhibited good stability and preserved the antioxidant activity of genistein. The gel-like matrix showed excellent stability and increased skin deposition of genistein compared to free genistein.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Roberto Gonzalez-Martin, Andrea Palomar, Alicia Quinonero, Nuria Pellicer, Caroline Zuckerman, Christine Whitehead, Richard T. Scott, Francisco Dominguez
Summary: In this study, the impact of phytoestrogens on IVF outcomes was investigated. Higher concentrations of phytoestrogens in follicular fluid and urine were found to be associated with improved reproductive outcomes. Additional studies are needed to optimize the use of phytoestrogens in IVF treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Maria-Eleni Grafakou, Christina Barda, Ekaterina-Michaela Tomou, Helen Skaltsa
Summary: The genus Genista, with its widespread distribution worldwide, has long been of interest for its medicinal properties, including treating respiratory diseases, rheumatic disorders, and diabetes. It contains over 108 flavonoids, with isoflavones being important secondary metabolites. The extracts of Genista species may have therapeutic effects on inflammation, pain, cancer, and other human ailments.